Experimental investigation on the bending behaviour of hybrid and steel thin walled box beams—The role of adhesive joints

In the automotive design, nowadays there are two fundamental drivers. On one hand there are the environmental problems, on the other hand there are the safety matters. Within this contest, the weight reduction has become a key driver in the design of vehicles and it is necessary to consider and to study the use of nonconventional materials taking advantage from their high potential of weight reduction and energy absorption capability. In this perspective, the aim of this work is the study of the structural behaviour of box beams by means of a series of three points bending tests. The examined cross sections are those typically used in automotive construction. Different type of materials (steel, composite) and joining technologies (adhesive, spot weld) have been examined, considering different configurations. The work put in evidence the advantages coming from the use of adhesive, which allows structures with important weight reduction and better mechanical properties than traditional joining solution

The effect of target thickness on the ballistic performance of ultra high molecular weight polyethylene composite

The ballistic performance of thick ultra-high molecular weight polyethylene (UHMW-PE) composite was experimentally determined for panel thicknesses ranging from 9 mm to 100 mm against 12.7 mm and 20 mm calibre fragment simulating projectiles (FSPs). Thin panels (similar to <10 mm thick) were observed to undergo large deflection and bulging, failing predominantly in fibre tension. With increased thickness the panels demonstrated a two-stage penetration process: shear plugging during the initial penetration followed by the formation of a transition plane and bulging of a separated rear panel. The transition plane between the two penetration stages was found to vary with impact velocity and target thickness. These variables are inter-related in ballistic limit testing as thicker targets are tested at higher velocities. An analytical model was developed to describe the two-stages of perforation, based on energy and momentum conservation. The shear plugging stage is characterised in terms of work required to produce a shear plug in the target material, while the bulging and membrane tension phase is based on momentum and classical yarn theory. The model was found to provide very good agreement with the experimental results for thick targets that displayed the two-stage penetration process. For thin targets, which did not show the initial shear plugging phase, analytical models for membranes were demonstrated as suitable

The efficiency of ultra-high molecular weight polyethylene composite against fragment impact

This paper presents an experimental investigation into the ballistic resistance of ultra-high molecular weight polyethylene (UHMW-PE) composite, and compares its performance against a range of common metallic and composite armour materials. An extensive experimental program was conducted to determine the ballistic limit velocity (V<inf>50</inf>) of UHMW-PE composite against 12.7 and 20 mm fragment simulating projectiles (FSPs) for a wide range of thicknesses. For protection against these projectiles, UHMW-PE composite was found to be consistently more mass efficient than rolled homogeneous armour steel (RHA), high hardness armour steel (HHA), aluminium alloy 5059-H131, and polymer composites reinforced with aramid, glass or carbon fibres. In terms of armour space claim, UHMW-PE composite was found to be less efficient than both steel types and glass fibre-reinforced plastic, though it was comparable to aramid fibre-reinforced plastic, and was more efficient than aluminium 5059-H131 and carbon fibre-reinforced plastic. Scaling effects were observed that showed metals were more effective against smaller projectiles in terms of armour mass required to stop a given projectile kinetic energy. These effects were not observed to the same extent for UHMW-PE composite, giving rise to a higher UHMW-PE mass efficiency against larger projectiles

Impact of Intermediate Hyperglycemia and Diabetes on Immune Dysfunction in Tuberculosis

Supplementary Data: Supplementary materials are available at Clinical Infectious Diseases online at https://academic.oup.com/cid/article/72/1/69/5857148#274319223 . Consisting of data provided by the authors to benefit the reader, the posted materials are not copyedited and are the sole responsibility of the authors, so questions or comments should be addressed to the corresponding author.Copyright © The Author(s) 2020. Background: People with diabetes have an increased risk of developing active tuberculosis (TB) and are more likely to have poor TB-treatment outcomes, which may impact on control of TB as the prevalence of diabetes is increasing worldwide. Blood transcriptomes are altered in patients with active TB relative to healthy individuals. The effects of diabetes and intermediate hyperglycemia (IH) on this transcriptomic signature were investigated to enhance understanding of immunological susceptibility in diabetes-TB comorbidity. Methods: Whole blood samples were collected from active TB patients with diabetes (glycated hemoglobin [HbA1c] ≥6.5%) or IH (HbA1c = 5.7% to <6.5%), TB-only patients, and healthy controls in 4 countries: South Africa, Romania, Indonesia, and Peru. Differential blood gene expression was determined by RNA-seq (n = 249). Results: Diabetes increased the magnitude of gene expression change in the host transcriptome in TB, notably showing an increase in genes associated with innate inflammatory and decrease in adaptive immune responses. Strikingly, patients with IH and TB exhibited blood transcriptomes much more similar to patients with diabetes-TB than to patients with only TB. Both diabetes-TB and IH-TB patients had a decreased type I interferon response relative to TB-only patients. Conclusions: Comorbidity in individuals with both TB and diabetes is associated with altered transcriptomes, with an expected enhanced inflammation in the presence of both conditions, but also reduced type I interferon responses in comorbid patients, suggesting an unexpected uncoupling of the TB transcriptome phenotype. These immunological dysfunctions are also present in individuals with IH, showing that altered immunity to TB may also be present in this group. The TB disease outcomes in individuals with IH diagnosed with TB should be investigated further.European Union’s Seventh Framework Programme (FP7 2007-2013 - Health) under grant agreement No 305279

A penetration model for semi-infinite composite targets

A penetration model for composites reinforced with high tenacity fibres like ultra-high molecular weight polyethylene (UHMW-PE) is proposed based on the modified Bernoulli theory typically used for metallic targets. The model describes penetration by tensile failure of the composite material through compression loading in an infinitely thick target and includes consideration for projectile deformation. The predicted projectile velocity and axial interface loads shows good agreement with numerical simulations for a deforming and rigid projectile condition against two grades of UHMW-PE composite. The model can also be used to predict transient projectile velocity and interface loads during the first phase of penetration (which acts over most of the penetration event) for a target of finite thickness. It was shown that transition to bulging occurs upon the arrival of the rarefaction wave, generated from the back of an unsupported target, at the projectile-target interface. The stress relief can lead to a change in penetration mode when the magnitude of release is sufficient to reduce the load at the interface below that of the target strength. This change in mode occurs late in the penetration event, and the model developed in this work is demonstrated to be valid up to this point

Polymorphisms in autophagy genes and active pulmonary tuberculosis susceptibility in Romania

Contains fulltext : 189236.pdf (Publisher’s version ) (Open Access

The effect of target thickness on the ballistic performance of ultra high molecular weight polyethylene composite

The ballistic performance of thick ultra-high molecular weight polyethylene (UHMW-PE) composite was experimentally determined for panel thicknesses ranging from 9 mm to 100 mm against 12.7 mm and 20 mm calibre fragment simulating projectiles (FSPs). Thin panels (∼<10 mm thick) were observed to undergo large deflection and bulging, failing predominantly in fibre tension. With increased thickness the panels demonstrated a two-stage penetration process: shear plugging during the initial penetration followed by the formation of a transition plane and bulging of a separated rear panel. The transition plane between the two penetration stages was found to vary with impact velocity and target thickness. These variables are inter-related in ballistic limit testing as thicker targets are tested at higher velocities. An analytical model was developed to describe the two-stages of perforation, based on energy and momentum conservation. The shear plugging stage is characterised in terms of work required to produce a shear plug in the target material, while the bulging and membrane tension phase is based on momentum and classical yarn theory. The model was found to provide very good agreement with the experimental results for thick targets that displayed the two-stage penetration process. For thin targets, which did not show the initial shear plugging phase, analytical models for membranes were demonstrated as suitable

Different patterns of Toll-like receptor 2 polymorphisms in populations of various ethnic and geographic origins.

Item does not contain fulltextUpon the invasion of the host by microorganisms, innate immunity is triggered through pathogen recognition by pattern recognition receptors (PRRs). Toll-like receptors (TLRs) are the best-studied class of PRRs, and they recognize specific pathogen-associated molecular patterns (PAMPs) from various microorganisms. A large number of studies have shown that genetic variation in TLRs may influence susceptibility to infections. We assessed the genetic variation of TLR2, which encodes one of the most important TLRs, in various populations around the globe and correlated it with changes in the function of the molecule. The three best-known nonsynonymous TLR2 polymorphisms (1892C>A, 2029C>T, and 2258G>A) were assessed in different populations from the main continental masses: Romanians, Vlax-Roma, Dutch (European populations), Han Chinese (East Asia), Dogon, Fulani (Africa), and Trio Indians (America). The 2029C>T polymorphism was absent in both European and non-European populations, with the exception of the Vlax-Roma, suggesting that this polymorphism most likely arose in Indo-Aryan people after migration into South Asia. The 1892C>A polymorphism that was found exclusively in European populations, but not in Asian, African, or American volunteers, probably occurred in proto-Indo-Europeans. Interestingly, 2258G>A was present only in Europeans, including Vlax-Roma, but at a very low frequency. The differential pattern of the TLR2 polymorphisms in various populations may explain some of the differences in susceptibility to infections between these populations.1 mei 201