Anticoagulant activity of a synthetic heparinoid in relation to molecular weight and N-sulfate content

Addition of chlorosulfonyl isocyanate to C=C bonds in cis-1,4-polyisoprene and reaction of the adduct with NaOH resulted in the formation of a water-soluble polyelectrolyte with N-sulfate and carboxylate groups. The polyelectrolyte showed anticoagulant activity and it was found, just as with heparin, that the activity was related to molecular weight and N-sulfate content

La sexualité de son voisin. Regard croisé des voyageurs français et italiens à travers le récit de leur voyage en France et en Italie (1730-1780)

À travers les récits de voyage, les mémoires et les correspondances, les ressortissants des diverses nations d'Europe racontent leur voyage dans d'autres sociétés et en profitent pour écrire sur les mœurs de leurs voisins. Dans ce travail de description, les contemporains jugent et regardent d'un œil nouveau ces coutumes si étrangères aux leurs. Parmi les descriptions données à lire, la sexualité tient une place non négligeable. C'est au prisme des habitudes sexuelles des populations locales, des pratiques sociales et intimes régissant les rapports entre les sexes aux seins du couple et dans l'espace public, que le voyageur cherche aussi à évaluer la société visitée. Par exemple, les Français qui, comme le rappelle Baretti, ont beaucoup écrit sur l'Italie, furent très prodigues dans la description des Italiens et de leur sexualité. Le contraire se vérifie également. Bien que moins prolixes, les Italiens ont écrit sur les Français et leur sexualité. Ainsi, au XVIIIe siècle, la description d'un autre pays ou d'une autre culture passe aussi par un regard sur la sexualité de l'autre. Le mémoire se propose d'étudier le regard des voyageurs français sur la sexualité des Italiens ainsi que la construction des représentations des Italiens sur la sexualité des Français à travers les récits, correspondances et mémoires écrits au cours du 18e siècle

A Numbers Game: How Analytics are Affecting Decision-Making in Professional Baseball

The game of baseball has been based on numbers since the first professional game was played. The game has evolved as the use of statistics has evolved and vice versa. At this point in the baseball’s progression, analytics and numbers are affecting every decision that is made, whether it is on the field or in the front office. This is not a concept that can be depicted using numbers. To better get at this concept, and to use skills taught at SUNY Brockport, journalism would be the best way to fully understand how teams use analytics and what impact those numbers have on the game. Journalism allows for the human element of things to be more pronounced. It is a form of writing that puts the subject first and takes the writer out of play. Due to this, having professionals to give their input on the topic allows experts their opportunity to say exactly how things happen. It takes guess work out of play and lets the story be told by someone who lives it out on a day-to-day basis.NASUNY BrockportHonors CollegeBAYoung, Ki

A Numbers Game: How Analytics are Affecting Decision-Making in Professional Baseball

The game of baseball has been based on numbers since the first professional game was played. The game has evolved as the use of statistics has evolved and vice versa. At this point in the baseball’s progression, analytics and numbers are affecting every decision that is made, whether it is on the field or in the front office. This is not a concept that can be depicted using numbers. To better get at this concept, and to use skills taught at SUNY Brockport, journalism would be the best way to fully understand how teams use analytics and what impact those numbers have on the game. Journalism allows for the human element of things to be more pronounced. It is a form of writing that puts the subject first and takes the writer out of play. Due to this, having professionals to give their input on the topic allows experts their opportunity to say exactly how things happen. It takes guess work out of play and lets the story be told by someone who lives it out on a day-to-day basis.NASUNY BrockportHonors CollegeBAYoung, Kimberl

Structural studies of capsular polysaccharide of type XII diplococcus pneumoniae

The capsular polysaccharide of Diplococcus pneumoniae Type XII contains residues of -glucose and -galactose in a molar ratio of 2:1. The methylated polysaccharide yielded upon hydrolysis 2,3,4,6-tetra- and 3,4,6-tri-O-methyl--glucose and 2,3,4,6-tetra-O-methyl--galactose as the only neutral methyl sugars. Periodate oxidation of the polysaccharide resulted in destruction of all neutral sugars and immunochemical activity against rabbit antisera. Periodate oxidation of the methyl O-methylglycosides obtained after hydrolysis of the methylated polysaccharide indicated that at least 30% of the -fucosamine residues are substituted at C-4 in the polysaccharide. It is concluded that the polysaccharide consists of a hexosamine backbone that is substituted by -galactosyl and kojibiosyl side-chains. The proposed terminal -galactosyl residues apparently are sterically hindered from interacting with several -galactose-binding proteins.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/22259/1/0000696.pd

Ultraviolet Difference Spectral Studies on Concanavalin A

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65204/1/j.1432-1033.1970.tb01116.x.pd

D-Glucuronic acid: A non-inhibitor of the concanavalin A system

D-Glucuronic acid is demonstrated not to inhibit the concanavalin A system; previous claims to the contrary are shown to be due to a pH effect. Concanavalin A does not precipitate biopolymers containing nonreducing, terminal [alpha]-D-glucopyranosiduronic acid residues.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/34081/1/0000360.pd

Protein-carbohydrate interaction : III. Agar gel-diffusion studies on the interaction of concanavalin A, a lectin isolated from jack bean, with polysaccharides

Concanavalin A, a protein isolated from the jack bean (Canavalia ensiformis), has previously been shown to form a precipitate with glycogen and yeast mannan, and more recently with dextrans and amylopectin. Double-diffusion precipitation studies in agar gel have been found to afford a very sensitive and satisfactory method for investigating the interaction of concanavalin A with certain types of branched, glucose- and mannose- containing polysaccharides. In this manner concanavalin A can be used as a reagent for the detection and preliminary characterization of various types of polysaccharides. Bacterial levans as well as certain plant fructans also form precipitation bands with concanavalin A. This observation represents the first report of such an interaction. The method may also provide an indication as to the heterogeneity of polysaccharide preparations that react with concanavalin A as well as affording preliminary information on the relative molecular size of a series of reactive polysaccharides. Inhibition of the precipitation bands by low molecular weight carbohydrate molecules may be demonstrated. These inhibition studies reveal the highly specific nature of the combining sites of the concanavalin A molecule.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/31996/1/0000038.pd

Some Recent Developments in the Pharmacology of Heparin

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97239/1/j.1552-4604.1979.tb02490.x.pd

Protein-carbohydrate interaction : On the mode of binding of aromatic moieties to concanavalin A, the phytohemagglutinin of the jack bean

A number of meta-alkylphenyl [beta]--glucopyranosides were synthesized and their ability to inhibit the concanavalin A-polysaccharide system was examined. The binding constants of these compounds as well as other substituted phenyl [amalgamation or coproduct]--glucopyranosides were related to the hydrophobic ([pi]) and electronic ([sigma]) nature of the substituents utilizing the equations devised by Hansch S and Hammett[paragraph sign] respectively.Regression analysis of these relationships revealed that: (1) no linear correlation between the binding constants and the electronic properties of the aromatic substituents was evident; (2) the molecular volume of mono-ortho-substituents does not significantly effect the binding of aromatic [beta]--glucopyranosides to concanavalin A; and (3) the hydrophobic nature ([pi]) of ortho- and meta- but not para-substituents is closely associated with the binding of aryl [beta]--glucosides to concanavalin A.It is proposed that apolar binding involving hydrophobic interactions associated with ortho and meta but not with the para positions of the aromatic nucleus are the predominant forces involved in the binding of the phenyl moiety of phenyl [beta]--glucosides to concanavalin A.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/33567/1/0000068.pd