DAzLE: The Dark Ages z (redshift) Lyman-alpha Explorer

DAzLE is an near infrared narrowband differential imager being built by the Institute of Astronomy, Cambridge, in collaboration with the Anglo-Australian observatory. It is a special purpose instrument designed with a sole aim; the detection of redshifted Lyman-alpha emission from star forming galaxies at z>7. DAzLE will use pairs of high resolution (R=1000) narrowband filters to exploit low background `windows' in the near infrared sky emission spectrum. This will enable it to reach sensitivities of ~2E-21 W/m^2, thereby allowing the detection of z>7 galaxies with star formation rates as low as a few solar masses per year. The design of the instrument, and in particular the crucial narrowband filters, are presented. The predicted performance of DAzLE, including the sensitivity, volume coverage and expected number counts, is discussed. The current status of the DAzLE project, and its projected timeline, are also presented.Comment: 11 pages, 7 figures, to appear in Proceedings of SPIE Vol. 5492, Ground-based Instrumentation for Astronom

Fast Decoders for Topological Quantum Codes

We present a family of algorithms, combining real-space renormalization methods and belief propagation, to estimate the free energy of a topologically ordered system in the presence of defects. Such an algorithm is needed to preserve the quantum information stored in the ground space of a topologically ordered system and to decode topological error-correcting codes. For a system of linear size L, our algorithm runs in time log L compared to L^6 needed for the minimum-weight perfect matching algorithm previously used in this context and achieves a higher depolarizing error threshold.Comment: 4 pages, 4 figure

A clinical pilot study on the effect of the probiotic Lacticaseibacillus rhamnosus TOM 22.8 strain in women with vaginal dysbiosis

Lactobacilli with probiotic features play an essential role in maintaining a balanced vaginal microbiota and their administration has been suggested for the treatment and prevention of vaginal dysbiosis. The present study was aimed to in vitro and in vivo investigate the probiotic potential of the Lacticaseibacillus rhamnosus TOM 22.8 strain, isolated from the vaginal ecosystem of a healthy woman. For this purpose, safety and functional properties were in depth evaluated. The strain exhibited a broad spectrum of antagonistic activity against vaginal pathogens; adhesion capacity to both the vaginal VK2/E6E7 and the intestinal Caco-2 cells; anti-inflammatory and antioxidant activities, suggesting its promising probiotic features. In addition, an in vivo pilot-study was planned. Based on both clinical and microbiological parameters, the oral or vaginal strain administration, determined a significant pathogens reduction after 10 days of administration and a maintenance of eubiosis up to 30 days after the end of the treatment. Therefore, the L. rhamnosus TOM 22.8 strain can be proposed as valuable oral and/or vaginal treatment for vaginal dysbiosis

Topological code Autotune

Many quantum systems are being investigated in the hope of building a large-scale quantum computer. All of these systems suffer from decoherence, resulting in errors during the execution of quantum gates. Quantum error correction enables reliable quantum computation given unreliable hardware. Unoptimized topological quantum error correction (TQEC), while still effective, performs very suboptimally, especially at low error rates. Hand optimizing the classical processing associated with a TQEC scheme for a specific system to achieve better error tolerance can be extremely laborious. We describe a tool Autotune capable of performing this optimization automatically, and give two highly distinct examples of its use and extreme outperformance of unoptimized TQEC. Autotune is designed to facilitate the precise study of real hardware running TQEC with every quantum gate having a realistic, physics-based error model.Comment: 13 pages, 17 figures, version accepted for publicatio

Optimal propagating fronts using Hamilton-Jacobi equations

The optimal handling of level sets associated to the solution of Hamilton-Jacobi equations such as the normal flow equation is investigated. The goal is to find the normal velocity minimizing a suitable cost functional that accounts for a desired behavior of level sets over time. Sufficient conditions of optimality are derived that require the solution of a system of nonlinear Hamilton-Jacobi equations. Since finding analytic solutions is difficult in general, the use of numerical methods to obtain approximate solutions is addressed by dealing with some case studies in two and three dimensions

Prospects of light sterile neutrino oscillation and CP violation searches at the Fermilab Short Baseline Neutrino Facility

We investigate the ability of the short baseline neutrino (SBN) experimental program at Fermilab to test the globally-allowed (3 þ N) sterile neutrino oscillation parameter space. We explicitly consider the globally-allowed parameter space for the (3 þ 1), (3 þ 2), and (3 þ 3) sterile neutrino oscillation scenarios. We find that SBN can probe with 5σ sensitivity more than 85%, 95% and 55% of the parameter space currently allowed at 99% confidence level for the (3 þ 1), (3 þ 2) and (3 þ 3) scenarios, respectively, with the (3 þ N) allowed space used in these studies closely resembling that of previous studies [J. M. Conrad, C. M. Ignarra, G. Karagiorgi, M. H. Shaevitz, and J. Spitz, Adv. High Energy Phys. 2013, 1 (2013).], calculated using the same methodology. In the case of the (3 þ 2) and (3 þ 3) scenarios, CP-violating phases appear in the oscillation probability terms, leading to observable differences in the appearance probabilities of neutrinos and antineutrinos. We explore SBN’s sensitivity to those phases for the (3 þ 2) scenario through the currently planned neutrino beam running, and investigate potential improvements through additional antineutrino beam running. We show that, if antineutrino exposure is considered, for maximal values of the (3 þ 2) CP-violating phase ϕ54, SBN could be the first experiment to directly observe ∼2σ hints of CP violation associated with an extended lepton sector

Current surgical concepts and indications in the management of the short bowel state: A call for the use of multidisciplinary intestinal rehabilitation programs

The mainstay of management for short bowel syndrome (SBS) is to promote access to the best quality of care provided by the intestinal rehabilitation program (IRP) in specialized centres. When treating SBS patients, the main goal is to minimize disease-associated complications, as well as achieve enteral autonomy. Surgical strategies should be selected cautiously upon the actual state of the bowel with respect to what it is clinically relevant for that specific patient. To this aim, a personalized and multidisciplinary approach for such a complex syndrome is needed

Foliated quantum error-correcting codes

We show how to construct a large class of quantum error-correcting codes, known as Calderbank-Steane-Shor codes, from highly entangled cluster states. This becomes a primitive in a protocol that foliates a series of such cluster states into a much larger cluster state, implementing foliated quantum error correction. We exemplify this construction with several familiar quantum error-correction codes and propose a generic method for decoding foliated codes. We numerically evaluate the error-correction performance of a family of finite-rate Calderbank-Steane-Shor codes known as turbo codes, finding that they perform well over moderate depth foliations. Foliated codes have applications for quantum repeaters and fault-tolerant measurement-based quantum computation