Symptomatic cavernous hemangioma of fronto-parietal region of the brain in a young female patient – a case report

Introduction: Cavernous hemangioma is a bening blood vessel malformation that can be located in the central nervous system. Although most patients who are found to have a CNS hemangioma are asymptomatic, the entity can cause a wide spectrum of symptoms including severe ones like epileptic seizures, stroke, diplopia, dysfasia or cognitive functions’ disorders. Case report: A 21-year-old female patient was admitted to the Department Of Neurology due to transient vision impairment, dysfasia, headache and tinnitus. Physical examination revealed no focal neurological signs. A brain MRI was performed. A cavernous hemangioma of 7-8 mm in size was found. The patient was examined by neurosurgeon as well, who did not qualify her for an immediate surgery. Discussion: Although cavernous hemangiomas are often asymptomatic, sometimes they can be a causative factor of different neurological symptoms. One should always take into account a possibility of cerebral hemangioma presence in young patients that suffer from headaches, tinnitis or have impaired vision

Migotanie przedsionków u pacjentów z kardiowerterem-defibrylatorem

Wstęp: Wśród pacjentów poddawanych zabiegowi implantacji kardiowertera-defibrylatora (ICD) z powodu groźnych arytmii komorowych są także osoby z utrwalonym migotaniem przedsionków (AF). U tych chorych istnieje możliwość nieoczekiwanego powrotu rytmu zatokowego w związku z interwencją ICD. W pracy zawarto opis 3 kolejnych przypadków pacjentów, u których obserwowano to zjawisko. Celem opracowania była ocena częstości tego zjawiska oraz próba określenia czynników sprzyjających powrotowi rymu zatokowego w tej specyficznej grupie. Materiał i metody: W grupie pierwszych 30 pacjentów poddanych implantacji ICD w rzeszowskim ośrodku u 3 chorych (3 mężczyzn w wieku 68-78 lat) przed zabiegiem rozpoznano utrwalone AF. Byli to pacjenci z wieloletnim AF, ciężkim uszkodzeniem serca oraz zaawansowaną niewydolnością serca. Wyniki: U wszystkich 3 chorych stwierdzono powrót rytmu zatokowego w różnych sytuacjach: w trakcie zabiegu implantacji ICD, jako efekt interwencji kardiowertera-defibrylatora w czasie hospitalizacji bądź w domu. Wnioski: Migotanie przedsionków stwierdzono u 3 pacjentów (10%) z 30-osobowej grupy badanej i u wszystkich obserwowano powrót rytmu zatokowego, który może się wiązać z konfiguracją cewek elektrody defibrylującej oraz leczeniem amiodaronem. Implantacja ICD powinna być dodatkowym argumentem wskazującym na celowość antykoagulacji w tej grupie. Omawiane zagadnienie wymaga przeprowadzenia większych badań

Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes

Regulatory landscapes drive complex developmental gene expression, but it remains unclear how their integrity is maintained when incorporating novel genes and functions during evolution. Here, we investigated how a placental mammal-specific gene, Zfp42, emerged in an ancient vertebrate topologically associated domain (TAD) without adopting or disrupting the conserved expression of its gene, Fat1. In ESCs, physical TAD partitioning separates Zfp42 and Fat1 with distinct local enhancers that drive their independent expression. This separation is driven by chromatin activity and not CTCF/cohesin. In contrast, in embryonic limbs, inactive Zfp42 shares Fat1’s intact TAD without responding to active Fat1 enhancers. However, neither Fat1 enhancer-incompatibility nor nuclear envelope-attachment account for Zfp42’s unresponsiveness. Rather, Zfp42’s promoter is rendered inert to enhancers by context-dependent DNA methylation. Thus, diverse mechanisms enabled the integration of independent Zfp42 regulation in the Fat1 locus. Critically, such regulatory complexity appears common in evolution as, genome wide, most TADs contain multiple independently expressed genes.We thank the Montpellier Ressources Imagerie facility (BioCampus Montpellier, Centre National de la Recherche Scientifique [CNRS], INSERM, University of Montpellier) and for computer resources from CINECA (ISCRA grant thanks to computer resources from INFN and CINECA [ISCRA Grant HP10C8JWU7]). G.C., Q.S., and F.B. were supported by a grant from the European Research Council (Advanced Grant 3DEpi, 788972) and by the CNRS. This work was funded by EMBO and the Wellcome Trust (ALTF1554-2016 and 206475/Z/17/Z; to M.I.R.) as well as the Deutsche Forschungsgemeinschaft (KR3985/7-3 and MU 880/16-1 to S.M.)

Why is IPv6 Deployment Important for the Internet Evolution?, Journal of Telecommunications and Information Technology, 2011, nr 2

Replacing the IPv4 protocol with IPv6 on the Internet is currently one of the aims of the European Union policy. The main reason for this replacement is the effeteness of the addresses pool in the IPv4 protocol, which can cause serious complications in the evolution of the Internet and its adaptation in new areas, e.g., in next generation mobile telephony or the so called Internet of Things. Simultaneously, the addressing capabilities of the IPv6 protocol are practically unlimited and its new functionalities increase the attractiveness of its usage. The article discusses the problems connected with the IPv6 deployment on the Internet. Especially, the rules for realization of the IPv6 deployment and rules for cooperation of IPv4 with IPv6 (including cooperation tests) in network infrastructure and in applications are presented. Moreover, the European projects’ results and the activity’s directions of the national project Future Internet Engineering are discussed

Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes

Regulatory landscapes drive complex developmental gene expression, but it remains unclear how their integrity is maintained when incorporating novel genes and functions during evolution. Here, we investigated how a placental mammal-specific gene, Zfp42, emerged in an ancient vertebrate topologically associated domain (TAD) without adopting or disrupting the conserved expression of its gene, Fat1. In ESCs, physical TAD partitioning separates Zfp42 and Fat1 with distinct local enhancers that drive their independent expression. This separation is driven by chromatin activity and not CTCF/cohesin. In contrast, in embryonic limbs, inactive Zfp42 shares Fat1's intact TAD without responding to active Fat1 enhancers. However, neither Fat1 enhancer-incompatibility nor nuclear envelope-attachment account for Zfp42's unresponsiveness. Rather, Zfp42's promoter is rendered inert to enhancers by context-dependent DNA methylation. Thus, diverse mechanisms enabled the integration of independent Zfp42 regulation in the Fat1 locus. Critically, such regulatory complexity appears common in evolution as, genome wide, most TADs contain multiple independently expressed genes