Chamber Structure and Wallcrossing in the ADHM Theory of Curves II

This is the second part of a project concerning variation of stability and chamber structure for ADHM invariants of curves. Wallcrossing formulas for such invariants are derived using the theory of stack function Ringel-Hall algebras constructed by Joyce and the theory of generalized Donaldson-Thomas invariants of Joyce and Song. Some applications are presented, including strong rationality for local stable pair invariants of higher genus curves and comparison with wallcrossing formulas of Kontsevich and Soibelman, and the halo formula of Denef and Moore.Comment: 32 pages, AMS LaTex; v.2: Thm 1.2 improved; v3: many proofs simplified based on a remark of Dominic Joyce, results unchanged; v3: 18 pages, shorter version to appear in J Geom Phy

A Note on Mirror Symmetry for Manifolds with Spin(7) Holonomy

Starting from the superconformal algebras associated with $G_2$ manifolds, I extend the algebra to the manifolds with spin(7) holonomy. I show how the mirror symmetry in manifolds with spin(7) holonomy arises as the automorphism in the extended sperconformal algebra. The automorphism is realized as 14 kinds of T-dualities on the supersymmetric $T^4$ toroidal fibrations. One class of Joyce's orbifolds are pairwise identified under the symmetry.Comment: 12 pages, harvmac bi

Climate forcing by carbonaceous and sulfate aerosols

 An atmospheric general circulation model is coupled to an atmospheric chemistry model to calculate the radiative forcing by anthropogenic sulfate and carbonaceous aerosols. The latter aerosols result from biomass burning as well as fossil fuel burning. The black carbon associated with carbonaceous aerosols is absorbant and can decrease the amount of reflected radiation at the top-of-the-atmosphere. In contrast, sulfate aerosols are reflectant and the amount of reflected radiation depends nonlinearly on the relative humidity. We examine the importance of treating the range of optical properties associated with sulfate aerosol at high relative humidities and find that the direct forcing by anthropogenic sulfate aerosols can decrease from −0.81 W m -2 to −0.55 Wm -2 if grid box average relative humidity is not allowed to increase above 90%. The climate forcing associated with fossil fuel emissions of carbonaceous aerosols is calculated to range from +0.16 to +0.20 Wm -2 , depending on how much organic carbon is associated with the black carbon from fossil fuel burning. The direct forcing of carbonaceous aerosols associated with biomass burning is calculated to range from −0.23 to −0.16 Wm -2 . The pattern of forcing by carbonaceous aerosols depends on both the surface albedo and the presence of clouds. Multiple scattering associated with clouds and high surface albedos can change the forcing from negative to positive.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42186/1/382-14-12-839_80140839.pd

Soot and smoke aerosol may not warm climate

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94810/1/jgrd10551.pd

Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device and Medical Management in Ambulatory Heart Failure Patients The ROADMAP Study 2-Year Results

OBJECTIVES The authors sought to provide the pre-specified primary endpoint of the ROADMAP (Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device and Medical Management in Ambulatory Heart Failure Patients) trial at 2 years. BACKGROUND The ROADMAP trial was a prospective nonrandomized observational study of 200 patients (97 with a left ventricular assist device [LVAD], 103 on optimal medical management [OMM]) that showed that survival with improved functional status at 1 year was better with LVADs compared with OMM in a patient population of ambulatory New York Heart Association functional class IIIb/IV patients. METHODS The primary composite endpoint was survival on original therapy with improvement in 6-min walk distance \u3e= 75 m. RESULTS Patients receiving LVAD versus OMM had lower baseline health-related quality of life, reduced Seattle Heart Failure Model 1-year survival (78% vs. 84%; p = 0.012), and were predominantly INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) profile 4 (65% vs. 34%; p \u3c 0.001) versus profiles 5 to 7. More LVAD patients met the primary endpoint at 2 years: 30% LVAD versus 12% OMM (odds ratio: 3.2 [95% confidence interval: 1.3 to 7.7]; p = 0.012). Survival as treated on original therapy at 2 years was greater for LVAD versus OMM (70 +/- 5% vs. 41 +/- 5%; p \u3c 0.001), but there was no difference in intent-to-treat survival (70 +/- 5% vs. 63 +/- 5%; p = 0.307). In the OMM arm, 23 of 103 (22%) received delayed LVADs (18 within 12 months; 5 from 12 to 24 months). LVAD adverse events declined after year 1 for bleeding (primarily gastrointestinal) and arrhythmias. CONCLUSIONS Survival on original therapy with improvement in 6-min walk distance was superior with LVAD compared with OMM at 2 years. Reduction in key adverse events beyond 1 year was observed in the LVAD group. The ROADMAP trial provides risk-benefit information to guide patient- and physician-shared decision making for elective LVAD therapy as a treatment for heart failure. (Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device and Medical Management in Ambulatory Heart Failure Patients [ROADMAP]; NCT01452802

Primary results of long-term outcomes in the MOMENTUM 3 pivotal trial and continued access protocol study phase: a study of 2200 HeartMate 3 left ventricular assist device implants

AIM: The MOMENTUM 3 pivotal trial established superiority of the HeartMate 3 (HM3) left ventricular assist device (LVAD), a fully magnetically levitated centrifugal-flow pump, over the HeartMate II axial-flow pump. We now evaluate HM3 LVAD outcomes in a single-arm prospective continuous access protocol (CAP) post-pivotal trial study. METHODS AND RESULTS: We enrolled 2200 HM3 implanted patients (515 pivotal trial and 1685 CAP patients) and compared outcomes including survival free of disabling stroke or reoperation to replace or remove a malfunctioning device (primary composite endpoint), overall survival and major adverse events at 2 years. The 2-year primary endpoint [76.7% vs. 74.8%; adjusted hazard ratio (HR) 0.87, 95% confidence interval (CI) 0.71-1.08, P = 0.21] and overall survival (81.2% vs. 79.0%) were similar among CAP and pivotal cohorts despite sicker patients (more intra-aortic balloon pump use and INTERMACS profile 1) in CAP who were more often intended for destination therapy. Survival was similar between the CAP and pivotal trial in transplant ineligible patients (79.1% vs. 76.7%; adjusted HR 0.89, 95% CI 0.68-1.16, P = 0.38). In a pooled analysis, the 2-year primary endpoint was similar between INTERMACS profiles 1-2 (\u27unstable\u27 advanced heart failure), profile 3 (\u27stable\u27 on inotropic therapy), and profiles 4-7 (\u27stable\u27 ambulatory advanced heart failure) (75.7% vs. 77.6% vs. 72.9%, respectively). The net burden of adverse events was lower in CAP (adjusted rate ratio 0.93, 95% CI 0.88-0.98, P = 0.006), with consequent decrease in hospitalization. CONCLUSIONS: The primary results of accumulating HM3 LVAD experience suggest a lower adverse event burden and similar survival compared to the pivotal MOMENTUM 3 trial

CosmoSIS: Modular cosmological parameter estimation

Cosmological parameter estimation is entering a new era. Large collaborations need to coordinate high-stakes analyses using multiple methods; furthermore such analyses have grown in complexity due to sophisticated models of cosmology and systematic uncertainties. In this paper we argue that modularity is the key to addressing these challenges: calculations should be broken up into interchangeable modular units with inputs and outputs clearly defined. We present a new framework for cosmological parameter estimation, CosmoSIS, designed to connect together, share, and advance development of inference tools across the community. We describe the modules already available in CosmoSIS, including CAMB, Planck, cosmic shear calculations, and a suite of samplers. We illustrate it using demonstration code that you can run out-of-the-box with the installer available at http://bitbucket.org/joezuntz/cosmosisComment: Finally got around to updating to refereed version. 31 pages, 8 figure

Phase Equilibration and Magnetic Field Generation in U(1) Bubble Collisions

We present the results of lattice computations of collisions of two expanding bubbles of true vacuum in the Abelian Higgs model with a first-order phase transition. New time-dependent analytical solutions for the Abelian field strength and the phase of the complex field are derived from initial conditions inferred from linear superposition and are shown to be in excellent agreement with the numerical solutions especially for the case where the initial phase difference between the bubbles is small. With a step-function approximation for the initial phase of the complex field, solutions for the Abelian field strength and other gauge-invariant quantities are obtained in closed form. Possible extensions of the solution to the case of the electroweak phase transition and the generation of primordial magnetic fields are briefly discussed.Comment: LaTeX, 41 pages, 6 figures, submitted to Physical Review