Re-Envisioning Professional Education

In the dynamic, hyper-connected, and unpredictable 21st century, workplace and career paradigms are rapidly changing. The professions are no exception. Technology has routinized and increased access to the expertise that traditionally set professionals apart from other workers, leading some to forecast professions’ demise. Even if, as we suspect, new forms of complexity and needs for expertise continue to outrun technology, professionals’ lives and careers will diverge dramatically from past norms. In the world we anticipate, the number of theories, diagnoses, and strategies among which each professional — alone or in teams — must make informed and workable judgments will increase exponentially, as will the rapidity with which their specialties become obsolete and have to be retooled or replaced. In this world, learning to learn will far outstrip the importance of applying the specialized knowledge with which professionals are initially programmed. If this prediction is correct, then university-based professional schools (hereinafter “professional schools”), which historically have done that initial programming, must change at the same pace as their graduates’ careers. Evidence that professional schools are not evolving quickly enough is widespread. Employers and policymakers criticize professional schools for not preparing graduates to succeed in the modern workplace or to solve increasingly acute public problems. And prospective students are voting with their feet, opting for less expensive and more relevant training from accelerators, boot camps, and massive open online courses (MOOCs) and in dynamic work environments themselves. In order to help the professions retool for the modern world, professional education must retool itself

Interface Design Practice and Education Towards Mobile Apps Development

AbstractMobile apps development has been gaining popularity in Malaysia over the past 3 years. An app usually refers to a software application or programme. Although the development of software applications have been around for decades, app development on mobile devices reached the shores of Malaysia, mainly due to the popularity of Apple's App Store. Software development and complex object-oriented programming have been the exclusive harbour of technology hobbyists, IT professionals and business executives for many years. The flourishing presence of Web applications and the over-whelming influence of social media has augmented our need for greater connectivity, sharing and online presence. These have allowed smartphones and gadgets to become mainstream. This paper looks at how a design institution in Malaysia provides the growth of mobile apps development, and in supporting the national agenda to drive the Malaysian web and mobile application development industry to global standards. The paper highlights the practice and education of user-centered interface design towards mobile apps development in the country

Leading Through Learning: Using Evolutionary Learning to Develop, Implement, and Improve Strategic Initiatives

Equitably educating students requires effective differentiation of services based on students’ strengths and needs. Doing so reliably at scale is difficult given the diversity of students and contexts in our public school systems and the diversity of needs created by historical and institutionalized discrimination against people of color, immigrants, and other populations. Still, a number of systems and organizations have succeeded in advancing equity at scale. They have done so by finding new ways to design, lead, and manage their operations and engage internal and external stakeholders – in our language, new ways to govern2 their work. Cutting across these promising governance practices are adult and student learning systems that provide transparency into how school leaders actually lead, teachers actually teach, and students actually learn day to day, school by school, classroom by classroom, and lesson by lesson. This combination of transparency, experimentation, and broad participation and knowledge sharing reveals effective ways to serve individual and groups of students, severing deeply entrenched links between student background, access to opportunity, and learning outcomes

Structural and Regulatory Characterization of the Placental Epigenome at Its Maternal Interface

Epigenetics can be loosely defined as the study of cellular “traits” that influence biological phenotype in a fashion that is not dependent on the underlying primary DNA sequence. One setting in which epigenetics is likely to have a profound influence on biological phenotype is during intrauterine development. In this context there is a defined and critical window during which balanced homeostasis is essential for normal fetal growth and development. We have carried out a detailed structural and functional analysis of the placental epigenome at its maternal interface. Specifically, we performed genome wide analysis of DNA methylation in samples of chorionic villus (CVS) and maternal blood cells (MBC) using both commercially available and custom designed microarrays. We then compared these data with genome wide transcription data for the same tissues. In addition to the discovery that CVS genomes are significantly more hypomethylated than their MBC counterparts, we identified numerous tissue-specific differentially methylated regions (T-DMRs). We further discovered that these T-DMRs are clustered spatially along the genome and are enriched for genes with tissue-specific biological functions. We identified unique patterns of DNA methylation associated with distinct genomic structures such as gene bodies, promoters and CpG islands and identified both direct and inverse relationships between DNA methylation levels and gene expression levels in gene bodies and promoters respectively. Furthermore, we found that these relationships were significantly associated with CpG content. We conclude that the early gestational placental DNA methylome is highly organized and is significantly and globally associated with transcription. These data provide a unique insight into the structural and regulatory characteristics of the placental epigenome at its maternal interface and will drive future analyses of the role of placental dysfunction in gestational disease

GPS TRACKING OF THE FORAGING MOVEMENTS OF OILBIRDS (STEATORNIS CARIPENSIS) FROM THE DUNSTON CAVE AT ASA WRIGHT NATURE CENTRE, TRINIDAD

The ranging behaviors of the Oilbird (Steatornis caripensis) in Trinidad are not well defined and are required to better outline fu- ture conservation management parameters for this species. Due to the nocturnal foraging behaviors of the Oilbird, past observations were restricted to colony site observations, video recordings, and limited electronic tracking over short periods. Utilizing newly developed small- scale Global Positioning System (GPS) data loggers, we were able to determine the flight and foraging behaviors of two oilbirds that roost at the Asa Wright Nature Centre for up to 270 days. The use of backpack style GPS tracking devices provided high site resolution and accuracy of the movements and a better understanding of the annual foraging behaviors of the oilbirds in the Asa Wright Nature Centre colony. The oilbirds’ home range was determined to be 3,564.6 km2, with an average trip distance from Dunston Cave of 7.33 km, excluding an interme- diary migration point in Venezuela. 48.5% of the foraging area consisted of locations within the Northern Range, while 27.7% of these trips remained within the Arima Valley, which is only partially protected from quarrying activities. This data document the previously unknown patterns of habitat use of the Oilbird and serves as a pilot study to determine the conservation importance of those habitats for the develop- ment of long-term conservation action plans for these iconic birds

Conformance analysis of clinical pathway using electronic health record data

Objectives: The objective of this study was to confirm the conformance rate of the actual usage of the clinical pathway (CP) using Electronic Health Record (EHR) log data in a tertiary general university hospital to improve the CP by reflecting realworld care processes. Methods: We analyzed the application and matching rates of clinicians??? orders with predefined CP order sets based on data from 164 inpatients who received appendectomies out of all patients who were hospitalized from August 2013 to June 2014. We collected EHR log data on patient information, medication orders, operation performed, diagnosis, transfer, and CP order sets. The data were statistically analyzed. Results: The average value of the actual application rate of the prescribed CP order ranged from 0.75 to 0.89. The application rate decreased when the order date was factored in along with the order code and type. Among CP pre-operation, intra-operation, post-operation, routine, and discharge orders, orders pertaining to operations had higher application rates than other types of orders. Routine orders and discharge orders had lower application rates. Conclusions: This analysis of the application and matching rates of CP orders suggests that it is possible to improve these rates by updating the existing CP order sets for routine discharge orders to reflect data-driven evidence. This study shows that it is possible to improve the application and matching rates of the CP using EHR log data. However, further research should be performed to analyze the effects of these rates on care outcomes. © 2015 The Korean Society of Medical Informaticsopen0

Effects of receptor clustering on ligand dissociation: Theory and simulations

Receptor-ligand binding is a critical first step in signal transduction and the duration of the interaction can impact signal generation. In mammalian cells, clustering of receptors may be facilitated by heterogeneous zones of lipids, known as lipid rafts. In vitro experiments show that disruption of rafts significantly alters the dissociation of fibroblast growth factor-2 (FGF-2) from heparan sulfate proteoglycans, co-receptors for FGF-2. In this paper, we develop a continuum stochastic formalism in order to (i) study how rebinding affects the dissociation of ligands from a planar substrate, and (ii) address the question of how receptor clustering influences ligand rebinding. We find that clusters reduce the effective dissociation rate dramatically when the clusters are dense and the overall surface density of receptors is low. The effect is much less pronounced in the case of high receptor density and shows non-monotonic behavior with time. These predictions are verified via lattice Monte Carlo simulations. Comparison with experimental results suggests that the theory does not capture the complete biological system. We speculate that additional co-operative mechanisms might be present in order to increase ligand retention, and present one possible ``internal diffusion'' model.Comment: Expanded text and added figures, revised version to appear in Biophys.

HMU fluorinze mouthwash enhances enamel remineralization: An in vitro study

BACKGROUND: Fluoride therapy has long been used extensively to prevent dental caries. Fluoride appears in variety of dental care products such as mouthrinse, dentifrice, gel, etc. HMU fluorinze is the first mouthwash containing fluoride in Vietnam. AIM: This research was conducted to evaluate the efficacy of HMU Fluorinze mouthwash on remineralizing enamel in laboratory conditions. METHODS: 20 third molars teeth were cleaned and covered with nail polish , except for a 3x3 mm square on their buccal surfaces. These teeth went through two steps: demineralization using Coke and remineralization for 20 days: 1) using standard calcifying solution (control group) and 2) using standard calcifying solution + HMU Fluorinze mouthwash 2 times/day (experimental group). The mineralization index of enamel structure after demineralization and remineralization was assessed by DIAGNOdent pen 2190. RESULTS: The mineralization indexes of the control group and experimental group at baseline were 3.65 ± 0.76 and 3.35 ± 0.64, after demineralization were in turn of 21.78 ± 4.48 and 20.25 ± 2.26; and after remineralization were 6.30 ± 1.03 and 3.90 ± 1.24. The different figures  between the two groups after remineralization shows statistical significance (p<0.01). Group B using HMU fluorinze mouthwash after 20 days did not differ from the original results (p = 0.272), in contrast with the control group (p<0.01). CONCLUSIONS: HMU fluorinze mouthwash has better mineralization effect than standard calcifying solution

X-ray Emission from Nitrogen-Type Wolf-Rayet Stars

We summarize new X-ray detections of four nitrogen-type Wolf-Rayet (WR) stars obtained in a limited survey aimed at establishing the X-ray properties of WN stars across their full range of spectral subtypes. None of the detected stars is so far known to be a close binary. We report Chandra detections of WR 2 (WN2), WR 18 (WN4), and WR 134 (WN6), and an XMM-Newton detection of WR79a (WN9ha). These observations clearly demonstrate that both WNE and WNL stars are X-ray sources. We also discuss Chandra archive detections of the WN6h stars WR 20b, WR 24, and WR 136 and ROSAT non-detections of WR 16 (WN8h) and WR 78 (WN7h). The X-ray spectra of all WN detections show prominent emission lines and an admixture of cool (kT 2 keV) plasma. The hotter plasma is not predicted by radiative wind shock models and other as yet unidentified mechanisms are at work. Most stars show X-ray absorption in excess of that expected from visual extinction (Av), likely due to their strong winds or cold circumstellar gas. Existing data suggest a falloff in X-ray luminosity toward later WN7-9 subtypes, which have higher Lbol but slower, denser winds than WN2-6 stars. This provides a clue that wind properties may be a more crucial factor in determining emergent X-ray emission levels than bolometric luminosity.Comment: 42 pages, 5 tables, 10 figure

Comparative Genomic Characterization of the Multimammate Mouse Mastomys coucha.

Mastomys are the most widespread African rodent and carriers of various diseases such as the plague or Lassa virus. In addition, mastomys have rapidly gained a large number of mammary glands. Here, we generated a genome, variome, and transcriptomes for Mastomys coucha. As mastomys diverged at similar times from mouse and rat, we demonstrate their utility as a comparative genomic tool for these commonly used animal models. Furthermore, we identified over 500 mastomys accelerated regions, often residing near important mammary developmental genes or within their exons leading to protein sequence changes. Functional characterization of a noncoding mastomys accelerated region, located in the HoxD locus, showed enhancer activity in mouse developing mammary glands. Combined, our results provide genomic resources for mastomys and highlight their potential both as a comparative genomic tool and for the identification of mammary gland number determining factors