4,710 research outputs found
The Vital Ambiguity of Surface: Culturally Determined Notions of Metaphor and Performance in Contemporary Building Material
This thesis investigates the systems and information decipherable within a material surface; more specifically, those ideas of value, performance, and function we may infer from the surface of contemporary building materials. When these materials are reduced to their flattened image, the cosmetic facade of a surface has the capacity to inform as well as deceive. Additionally, we may see in materials outward properties, such as color or tactility, the capacity for metaphor and the application of a symbolic personhood. This thesis seeks to comprehend the ways in which these expectations become fodder for complication and paradox, and promote a perceptual mutability
Integrated support structure
This Major Qualifying Project is part of the Advanced Space Design Program at WPI. The goal is to design a support structure for a NASA GetAway Special experimental canister. The payload integration, weight, volume, and structural integrity of the canister as specified by NASA guidelines were studied. The end result is a complete set of design drawings with interface drawings and data to specify the design and leave a base on which the next group can concentrate
Association is not causation: treatment effects cannot be estimated from observational data in heart failure
Aims:
Treatment âeffectsâ are often inferred from non-randomized and observational studies. These studies have inherent biases and limitations, which may make therapeutic inferences based on their results unreliable. We compared the conflicting findings of these studies to those of prospective randomized controlled trials (RCTs) in relation to pharmacological treatments for heart failure (HF).
Methods and results:
We searched Medline and Embase to identify studies of the association between non-randomized drug therapy and all-cause mortality in patients with HF until 31 December 2017. The treatments of interest were: angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, mineralocorticoid receptor antagonists (MRAs), statins, and digoxin. We compared the findings of these observational studies with those of relevant RCTs. We identified 92 publications, reporting 94 non-randomized studies, describing 158 estimates of the âeffectâ of the six treatments of interest on all-cause mortality, i.e. some studies examined more than one treatment and/or HF phenotype. These six treatments had been tested in 25 RCTs. For example, two pivotal RCTs showed that MRAs reduced mortality in patients with HF with reduced ejection fraction. However, only one of 12 non-randomized studies found that MRAs were of benefit, with 10 finding a neutral effect, and one a harmful effect.
Conclusion:
This comprehensive comparison of studies of non-randomized data with the findings of RCTs in HF shows that it is not possible to make reliable therapeutic inferences from observational associations. While trials undoubtedly leave gaps in evidence and enrol selected participants, they clearly remain the best guide to the treatment of patients
Looking for Friends, Fans and Followers? Social Media Use in Public and Nonprofit Human Services
This article uses interviews and internet data to examine social media use among nonprofit organizations and county departments involved in the delivery of human services in a six-county area in South Central New York State. Social media use was modest; and nonprofit organizations were much more likely to use it than county departments. Organizations used social media primarily to market organizational activities, remain relevant to key constituencies and raise community awareness. Most organizations either had a narrow view of social mediaâs potential value or lacked long-term vision. Barriers to use included institutional policies, concerns about its inappropriateness for target audiences, and client confidentiality. The findings build on recent research regarding the extent to which nonprofit organizations and local governments use social media to engage stakeholders. Future research should investigate not only the different ways organizations use social media but also whether organizations use it strategically to advance organizational goals
Optically Clear Adhesives for OLED
Optically clear adhesives (OCA) have been used for more than a decade to bond rigid LCD and AMOLED displays for consumer electronics applications, offering optical, mechanical, and electrical performance benefits. The performance requirements of an OCA to bond cover window, touch sensors, and circular polarizers in a plastic OLED display to bent cover glass or a flexible, foldable OLED display are drastically different from a flat, rigid device. For plastic OLED to bent cover glass bonding, the adhesive needs to be strong enough to resist spring back of the flat, plastic OLED devices. For flexible, foldable OLED displays, the neutral plane needs to be managed during folding keeping strain to a minimum in critical layers of the device (e.g., touch sensor, TFT, TFE), and the OCA cannot deform (or cause other layers to deform) during the folding process. Folding also brings challenges to touch sensors that can no longer use conventional passivation layers. As a result, the OCA will be responsible for preventing corrosion of touch sensor materials such as metal mesh, silver nanowire, carbon nanotube, and graphene. The chapter will discuss OCA performance requirements for rigid, flexible, and foldable OLED bonding
Development of a nanoarray capable of the rapid and simultaneous detection of zearalenone, T2-toxin and fumonisin
Effect of abdominal binding on respiratory mechanics during exercise in athletes with cervical spinal cord injury
West CR, Goosey-Tolfrey VL, Campbell IG, Romer LM. Effect of
abdominal binding on respiratory mechanics during exercise in athletes
with cervical spinal cord injury. J Appl Physiol 117: 36â45, 2014. First
published May 22, 2014; doi:10.1152/japplphysiol.00218.2014.âWe
asked whether elastic binding of the abdomen influences respiratory
mechanics during wheelchair propulsion in athletes with cervical
spinal cord injury (SCI). Eight Paralympic wheelchair rugby players
with motor-complete SCI (C5-C7) performed submaximal and maximal
incremental exercise tests on a treadmill, both with and without
abdominal binding. Measurements included pulmonary function,
pressure-derived indices of respiratory mechanics, operating lung
volumes, tidal flow-volume data, gas exchange, blood lactate, and
symptoms. Residual volume and functional residual capacity were
reduced with binding (77 18 and 81 11% of unbound, P 0.05),
vital capacity was increased (114 9%, P 0.05), whereas total lung
capacity was relatively well preserved (99 5%). During exercise,
binding introduced a passive increase in transdiaphragmatic pressure,
due primarily to an increase in gastric pressure. Active pressures
during inspiration were similar across conditions. A sudden, sustained
rise in operating lung volumes was evident in the unbound condition,
and these volumes were shifted downward with binding.
Expiratory flow limitation did not occur in any subject and there
was substantial reserve to increase flow and volume in both
conditions. V Ë O2 was elevated with binding during the final stages
of exercise (8 â12%, P 0.05), whereas blood lactate concentration
was reduced (16 â19%, P 0.05). V Ë O2/heart rate slopes were
less steep with binding (62 35 vs. 47 24 ml/beat, P 0.05).
Ventilation, symptoms, and work rates were similar across conditions.
The results suggest that abdominal binding shifts tidal
breathing to lower lung volumes without influencing flow limitation,
symptoms, or exercise tolerance. Changes in respiratory
mechanics with binding may benefit O2 transport capacity by an
improvement in central circulatory function.This article has been made available through the Brunel Open Access Publishing Fund
Extreme magnetic field-boosted superconductivity
Applied magnetic fields underlie exotic quantum states, such as the
fractional quantum Hall effect and Bose-Einstein condensation of spin
excitations. Superconductivity, on the other hand, is inherently antagonistic
towards magnetic fields. Only in rare cases can these effects be mitigated over
limited fields, leading to reentrant superconductivity. Here, we report the
unprecedented coexistence of multiple high-field reentrant superconducting
phases in the spin-triplet superconductor UTe2. Strikingly, we observe
superconductivity in the highest magnetic field range identified for any
reentrant superconductor, beyond 65 T. These extreme properties reflect a new
kind of exotic superconductivity rooted in magnetic fluctuations and boosted by
a quantum dimensional crossover
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