Alternative School Administrators At Risk : What Does it Mean for Children?

Alternative public schools have evolved from their origins in school choice and the progressive education movement of the 1920\u27s into a system of schools that have become the assigned dumping ground for a population of ill-prepared, behaviorally disruptive youth, a population that is also disproportionately composed of minority students. Research suggests these schools fall short of providing an optimal educational opportunity for their students. There are multiple factors that place alternative school administrators at risk of failing in their charge to educate. Using a case study from a Midwestern alternative school, the author focuses on policy and the role of administrators, presenting interviews with the state legislator, the district superintendent responsible for oversight, and the school\u27s onsite administrator. The essay demonstrates implications of policy that emphasizes behavior over education and argues the need to develop a cultural climate within the alternative school far different than that of the traditional school. Policy must engage the role of parents, healthcare workers, social workers, probation officers

Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest

TGFbeta is critical to control hepatocyte proliferation by inducing G1-growth arrest through multiple pathways leading to inhibition of E2F transcription activity. The retinoblastoma protein pRb is a key controller of E2F activity and G1/S transition which can be inhibited in viral hepatitis. It is not known whether the impairment of pRb would alter the growth inhibitory potential of TGFbeta in disease. We asked how Rb-deficiency would affect responses to TGFbeta-induced cell cycle arrest.Publisher PDFPeer reviewe

A three-tier knowledge management scheme for software engineering support and innovation

To ensure smooth and successful transition of software innovations to enterprise systems, it is critical to maintain proper levels of knowledge about the system configuration, the operational environment, and the technology in both existing and new systems. We present a three-tier knowledge management scheme through a systematic planning of actions spanning the transition processes in levels from conceptual exploration to prototype development, experimentation, and product evaluation. The three-tier scheme is an integrated effort for bridging the development and operation communities, maintaining stability to the operational performance, and adapting swiftly to software technology innovations. The scheme combines experiences of academic researches and industrial practitioners to provide necessary technical expertise and qualifications for knowledge management in software engineering support (SES) processes

Laser-Derived Particle Size Data from CRP-3, Victoria Land Basin, Antarctica: Implications for Sequence and Seismic Stratigraphy

Seven hundred and nineteen samples from throughout the Cainozoic section in CRP-3 were analysed by a Malvern Mastersizer laser particle analyser, in order to derive a stratigraphic distribution of grain-size parameters downhole. Entropy analysis of these data (using the method of Woolfe & Michibayashi, 1995) allowed recognition of four groups of samples, each group characterised by a distinctive grain-size distribution. Group 1, which shows a multi-modal distribution, corresponds to mudrocks, interbedded mudrock/sandstone facies, muddy sandstones and diamictites. Group 2, with a sand-grade mode but showing wide dispersion of particle size, corresponds to muddy sandstones, a few cleaner sandstones and some conglomerates. Group 3 and Group 4 are also sand-dominated, with better grain-size sorting, and correspond to clean, well-washed sandstones of varying mean grain-size (medium and fine modes, respectively). The downhole disappearance of Group 1, and dominance of Groups 3 and 4 reflect a concomitant change from mudrock- and diamictite-rich lithology to a section dominated by clean, well-washed sandstones with minor conglomerates. Progressive downhole increases in percentage sand and principal mode also reflect these changes. Significant shifts in grain-size parameters and entropy group membership were noted across sequence boundaries and seismic reflectors, as recognised in other studies

University Band Symphonic Band

Braden Auditorium Bone Student Center Wednesday Evening April 24, 2002 8:00 p.m

Illinois State University University Band Symphonic Band

Center for the Performing Arts Wednesday Evening April 23, 2003 8:00p.m

University Band Symphonic Band

Braden Auditorium Bone Student Center Wednesday Evening April 25, 2001 8:00p.m

When and Why? The Chronology and Context of Flint Mining at Grime’s Graves, Norfolk, England

New radiocarbon dating and chronological modelling have refined understanding of the character and circumstances of flint mining at Grime’s Graves through time. The deepest, most complex galleried shafts were worked probably from the third quarter of the 27th century cal BC and are amongst the earliest on the site. Their use ended in the decades around 2400 cal BC, although the use of simple, shallow pits in the west of the site continued for perhaps another three centuries. The final use of galleried shafts coincides with the first evidence of Beaker pottery and copper metallurgy in Britain. After a gap of around half a millennium, flint mining at Grime’s Graves briefly resumed, probably from the middle of the 16th century cal BC to the middle of the 15th. These ‘primitive’ pits, as they were termed in the inter-war period, were worked using bone tools that can be paralleled in Early Bronze Age copper mines. Finally, the scale and intensity of Middle Bronze Age middening on the site is revealed, as it occurred over a period of probably no more than a few decades in the 14th century cal BC. The possibility of connections between metalworking at Grime’s Graves at this time and contemporary deposition of bronzes in the nearby Fens is discussed

Glucose Regulation of Thrombospondin and Its Role in the Modulation of Smooth Muscle Cell Proliferation

Smooth muscle cells (SMC) maintained in high glucose are more responsive to IGF-I than those in normal glucose. There is significantly more thrombospondin-1 (TSP-1) in extracellular matrix surrounding SMC grown in 25 mM glucose. In this study we investigated 1) the mechanism by which glucose regulates TSP-1 levels and 2) the mechanism by which TS-1 enhances IGF-I signaling. The addition of TSP-1 to primary SMC was sufficient to enhance IGF-I responsiveness in normal glucose. Reducing TSP-1 protein levels inhibited IGF-I signaling in SMC maintained in high glucose. We determined that TSP-1 protected IAP/CD47 from cleavage and thereby facilitated its association with SHP substrate-1 (SHPS-1). We have shown previously that the hyperglycemia induced protection of IAP from cleavage is an important component of the ability of hyperglycemia to enhance IGF-I signaling. Furthermore we determined that TSP-1 also enhanced phosphorylation of the β3 subunit of the αVβ3 integrin, another molecular event that we have shown are critical for SMC response to IGF-I in high glucose. Our studies also revealed that the difference in the amount of TSP-1 in the two different glucose conditions was due, at least in part, to a difference in the cellular uptake and degradation of TSP-1