Innovative psychological treatments for depression

A number of high-intensity psychosocial interventions have been shown to be as efficacious as and more enduring than medications in the treatment of nonpsychotic depression. Moreover, there have been important advances in the development of strategies to facilitate the selection of the best treatment for a given patient with a depression diagnosis. However, the demand for services is too great to be met by conventional high-intensity approaches alone. Some of the most exciting work in recent years has focused on the development of low-intensity approaches that can benefit many people and do so cost-effectively

Investigations into cataract formation in sciaenid fish species from the Elizabeth River, Chesapeake Bay, Virginia

Cataract formation in the Elizabeth River (ER) has been reported since 1986. Previous studies have concentrated on describing cataract as a function of exposure to polluted sediments, especially polycyclic aromatic hydrocarbons (PAH). These studies, however, have not examined what processes might be involved in fish cataractogenesis. The overall objective of this research was to identify important processes associated with the early development of cataract in feral fish populations. Field studies were used to systematically examine cataract development. Cataract in sciaenids was not associated with previously described cataractogenic factors, but could be linked to contaminated sediments of the ER. Cataract was highly prevalent, first appeared at the visible center of the lens, varied in the degree opacification (&\u3c&10-100%), could be classified into stages of development (stage 1-4), and inhibited lens growth. Furthermore, data showed that a positive association existed between bottom water temperatures (&\sp\circ&C) and cataract prevalence. Biochemical comparison of lenses revealed that the water content, cholesterol level, and free fatty acid composition were significantly elevated, total esters reduced, while no significant changes occurred in the protein composition of lenses with early cataract development. These data suggest that altered plasma membrane permeability might be involved in opacification. Investigations of cataract in fish at the cellular level have not been studied due to the absence of a reliable in vitro model. Protocols were established for the primary culture, successful passage (45 subcultures), and the long-term maintenance (54 months) of spot lens epithelial cells. Cells exhibited certain morphological characteristics, crystallin-protein composition, and chromosome complement indicative of epithelial cell differentiation and cell-line transformation. In vitro experiments indicated that both DNA and RNA indices were positively associated with cataract development in spot lenses. Results suggested that high molecular weight PAH may play a role in interfering with the mitotic cycle of epithelial cells. These results suggest that lens epithelial cells are disturbed and may be involved in the initial steps of cataractogenesis. In conclusion, results demonstrate that cataract development is associated with high levels of contamination found in the ER. Altered membrane permeability and epithelial cell function may play a key role in cataract initiation

Reconstruction of the Adaptable Deployable Entry and Placement Technology Sounding Rocket One Flight Test

The Adaptable Deployable Entry and Placement Technology Sounding Rocket One flight test is a demonstration experiment for deployable atmospheric decelerator technologies. The suborbital flight test occurred on 12 September 2018, at the White Sands Missile Range. Data from on-board and ground-based sensors were collected, from which the as-flown trajectory was reconstructed using an iterative extended Kalman filter-smoother. This paper describes the methodology, test vehicle instrumentation, and data analysis results from the flight test trajectory reconstruction

The Effect of Pedal Crank Arm Length on Lower Limb Joint Angles in an Upright Cycling Position

The purpose of this investigation was to determine whether changes in CAL resulted in significant changes in joint angles, and how these changes are related to changes in cycling performance

Bank Competition: Measurement, Decision-Making, and Risk Profiles

This paper investigates how competition impacts the future operating decisions and risk profile of banks. We construct a comprehensive, time-varying, bank-specific measure of a bank’s competitive environment (BCE) using textual analysis of banks’ 10-K filings. Using U.S. branch banking deregulation to capture exogenous changes in threats of entry, we provide evidence that BCE is a timely measure of real competitive pressures by showing that it significantly increases following decreases in barriers to entry. Measuring competition with BCE, we find that higher competition is associated with lower underwriting standards, less timely loan loss recognition and a shift towards non-interest revenue. Further, we find that higher competition is associated with higher stand-alone risk of individual banks, greater sensitivity of a bank’s downside equity risk to system-wide distress, and a greater contribution by individual banks to downside risk of the banking sector. We then show that these results using BCE are largely robust to replacing BCE with branch bank deregulation. Finally, we show that our BCE results hold in a post-deregulation analysis restricted to time periods following the final deregulation event in each state. These results combine to suggest that competition increases the risk profile of banks and that BCE can be of value to researchers and analysts for measuring competitive pressure at any point in time, regardless of the existence of a regulatory event.http://deepblue.lib.umich.edu/bitstream/2027.42/107866/1/1243_Williams.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/107866/4/1243_Williams_Jan2015.pdfDescription of 1243_Williams_Jan2015.pdf : January 2015 revision (new title

Do Resident and Non-Resident Northern Bobwhite Hunters Self-Regulate Harvest Based on Population Size?

A variety of factors influence the relative strength of additive and compensatory mortality of harvest on northern bobwhite (Colinus virginianus) including covey dynamics, habitat fragmentation, and timing of harvest. State wildlife agencies have long believed regulations could be liberal because hunters will self-regulate effort when populations decrease. A confounding observation is that with lower population abundances, hunter skill and harvest rate increases because the more novice hunters do not participate. This raises the question whether non-resident small game hunters could have a larger impact at lower population levels if they have (1) more money to dedicate to out of state licenses and travel/lodging, and (2) time to dedicate to the hunting experience? We examined long-term bobwhite population and harvest data from Kansas (1966–1999) to learn if self-regulation differed between resident and non-resident small game hunters. The number of resident and non-resident small game hunters was related to their respective harvest of northern bobwhites. Decreasing October population index was associated with a decline in the number of resident bobwhite hunter days and harvest. Conversely, increasing numbers of non-resident hunters participated in the hunting season with higher hunter efficiency and a larger harvest at lower October population index levels. Total relative harvest decreased overwinter (Oct–Jan) survival. The Kansas resident bobwhite harvest is probably self-regulatory but non-resident harvest is not. Future harvest regulations should consider the impact of non-resident harvest

Delayed Expected Loss Recognition and the Risk Profile of Banks

This paper investigates the extent to which delayed expected loan loss recognition (DELR) is associated with greater vulnerability of banks to three distinct dimensions of risk: (1) stock market liquidity risk, (2) downside tail risk of individual banks, and (3) codependence of downside tail risk among banks. We hypothesize that DELR increases vulnerability to downside risk by creating expected loss overhangs that threaten future capital adequacy and by degrading bank transparency, which increases financing frictions and opportunities for risk‐shifting. We find that DELR is associated with higher correlations between bank‐level illiquidity and both aggregate banking sector illiquidity and market returns (i.e., higher liquidity risks) during recessions, suggesting that high DELR banks as a group may simultaneously face elevated financing frictions and enhanced opportunities for risk‐shifting behavior in crisis periods. With respect to downside risk, we find that during recessions DELR is associated with significantly higher risk of individual banks suffering severe drops in their equity values, where this association is magnified for banks with low capital levels. Consistent with increased systemic risk, we find that DELR is associated with significantly higher codependence between downside risk of individual banks and downside risk of the banking sector. We theorize that downside risk vulnerability at the individual bank level can translate into systemic risk by virtue of DELR creating a common source of risk vulnerability across high DELR banks simultaneously, which leads to risk codependence among banks and systemic effects from banks acting as part of a herd.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111770/1/joar12079.pd

The Radio Evolution of SN 2001gd

We present the results of observations of the radio emission from Supernova 2001gd in NGC 5033 from 2002 February 8 through 2006 September 25. The data were obtained using the Very Large Array at wavelengths of 1.3 cm (22.4 GHz), 2 cm (14.9 GHz), 3.6 cm (8.4 GHz), 6 cm (4.9 GHz), and 20 cm (1.5 GHz), with one upper limit at 90 cm (0.3 GHz). In addition, one detection has been provided by the Giant Metrewave Radio Telescope at 21 cm (1.4 GHz). SN 2001gd was discovered in the optical well past maximum light, so that it was not possible to obtain many of the early radio "turn-on" measurements which are important for estimating the local circumstellar medium (CSM) properties. Only at 20 cm were turn-on data available. However, our analysis and fitting of the radio light curves, and the assumption that the Type IIb SN 2001gd resembles the much better studied Type IIb SN 1993J, enables us to describe the radio evolution as being very regular through day ~550 and consistent with a nonthermal-emitting model with a thermal absorbing CSM. The presence of synchrotron-self absorption (SSA) at early times is implied by the data, but determination of the exact relationship between the SSA component from the emitting region and the free-free absorption component from the CSM is not possible as there are insufficient early measurements to distinguish between models. After day ~550, the radio emission exhibits a dramatically steeper decline rate which, assuming similarity to SN 1993J, can be described as an exponential decrease with an e-folding time of 500 days. We interpret this abrupt change in the radio flux density decline rate as implying a transition of the shock front into a more tenuous region of circumstellar material. A similar change in radio evolution has been seen earlier in other SNe such as SN 1988Z, SN 1980K, and SN 1993J.Comment: 3 tables, 2 figures, To appear in the Astrophysical Journa

Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)

Colitis can occur from viral or bacterial infections, ischemic insult, or autoimmune disorders; most notably Ulcerative Colitis and the colonic variant of Crohn’s Disease - Crohn’s Colitis. Acute colitis may present with abdominal pain and distention, malabsorption, diarrhea, hematochezia and mucus in the stool. We are beginning to understand the complex interactions between the environment, genetics, and epithelial barrier dysfunction in Inflammatory Bowel Disease and animal models of colitis have been essential in advancing our understanding of this disease. One popular model involves supplementing the drinking water of mice with low-molecular weight Dextran Sodium Sulfate (DSS), resulting in epithelial damage and a robust inflammatory response in the colon lasting several days 1.Variations of this approach can be used to model acute injury, acute injury followed by repair, and repeated cycles of DSS interspersed with recovery modeling chronic inflammatory diseases 2. After a single four-day treatment of 3% DSS in drinking water, mice show signs of acute colitis including weight loss, bloody stools, and diarrhea. Mice are euthanized at the conclusion of the treatment course and at necropsy dissected colons are processed and can be 'Swiss rolled" 3 to allow microscopic analysis of the entire colon or infused with formalin as "sausages" to allow macroscopic analysis. Tissue is then embedded in paraffin, sectioned, and stained for histologic review