Understanding mass fluvial erosion along a bank profile: using PEEP technology for quantifying retreat lengths and identifying event timing

This study provides fundamental examination of mass fluvial erosion along a stream bank by identifying event timing, quantifying retreat lengths, and providing ranges of incipient shear stress for hydraulically driven erosion. Mass fluvial erosion is defined here as the detachment of thin soil layers or conglomerates from the bank face under higher hydraulic shear stresses relative to surface fluvial erosion, or the entrainment of individual grains or aggregates under lower hydraulic shear stresses. We explore the relationship between the two regimes in a representative, US Midwestern stream with semi-cohesive bank soils, namely Clear Creek, IA. Photo-Electronic Erosion Pins (PEEPs) provide, for the first time, in situ measurements of mass fluvial erosion retreat lengths during a season. The PEEPs were installed at identical locations where surface fluvial erosion measurements exist for identifying the transition point between the two regimes. This transition is postulated to occur when the applied shear stress surpasses a second threshold, namely the critical shear stress for mass fluvial erosion. We hypothesize that the regimes are intricately related and surface fluvial erosion can facilitate mass fluvial erosion. Selective entrainment of unbound/exposed, mostly silt-sized particles at low shear stresses over sand-sized sediment can armor the bank surface, limiting the removal of the underlying soil. The armoring here is enhanced by cementation from the presence of optimal levels of sand and clay. Select studies show that fluvial erosion strength can increase several-fold when appropriate amounts of sand and clay are mixed and cement together. Hence, soil layers or conglomerates are entrained with higher flows. The critical shear stress for mass fluvial erosion was found to be an order of magnitude higher than that of surface fluvial erosion, and proceeded with higher (approximately 2–4 times) erodibility. The results were well represented by a mechanistic detachment model that captures the two regimes. Copyright © 2017 John Wiley & Sons, Ltd

The role of conduction system pacing in patients with atrial fibrillation

Conduction system pacing (CSP) has emerged as a promising novel delivery method for Cardiac Resynchronisation Therapy (CRT), providing an alternative to conventional biventricular epicardial (BiV) pacing in indicated patients. Despite increasing popularity and widespread uptake, CSP has rarely been specifically examined in patients with atrial fibrillation (AF), a cohort which forms a significant proportion of the heart failure (HF) population. In this review, we first examine the mechanistic evidence for the importance of sinus rhythm (SR) in CSP by allowing adjustment of atrioventricular delays (AVD) to achieve the optimal electrical response, and thus, whether the efficacy of CSP may be significantly attenuated compared to conventional BiV pacing in the presence of AF. We next evaluate the largest clinical body of evidence in this field, related to patients receiving CSP following atrioventricular nodal ablation (AVNA) for AF. Finally, we discuss how future research may be designed to address the vital question of how effective CSP in AF patients is, and the potential hurdles we may face in delivering such studies

Autonomic modulation in patients with heart failure increases beat-to-beat variability of ventricular action potential duration

Background: Exaggerated beat-to-beat variability of ventricular action potential duration (APD) is linked to arrhythmogenesis. Sympathetic stimulation has been shown to increase QT interval variability, but its effect on ventricular APD in humans has not been determined.Methods and Results: Eleven heart failure patients with implanted bi-ventricular pacing devices had activation–recovery intervals (ARI, surrogate for APD) recorded from LV epicardial electrodes under constant RV pacing. Sympathetic activity was increased using a standard autonomic challenge (Valsalva) and baroreceptor indices were applied to determine changes in sympathetic stimulation. Two Valsalvas were performed for each study and were repeated, both off and on bisoprolol. In addition sympathetic nerve activity (SNA) was measured from skin electrodes on the thorax using a novel validated method. Autonomic modulation significantly increased mean short-term variability in ARI; off bisoprolol mean STV increased from 3.73 ± 1.3 to 5.27 ± 1.04 ms (p = 0.01), on bisoprolol mean STV of ARI increased from 4.15 ± 1.14 to 4.62 ± 1 ms (p = 0.14). Adrenergic indices of the Valsalva demonstrated significantly reduced beta-adrenergic function when on bisoprolol (Δ pressure recovery time, p = 0.04; Δ systolic overshoot in Phase IV, p = 0.05). Corresponding increases in SNA from rest both off (1.4 uV, p < 0.01) and on (0.7 uV, p < 0.01) bisoprolol were also seen.Conclusions: Beat-to-beat variability of ventricular APD increases during brief periods of increased sympathetic activity in patients with heart failure. Bisoprolol reduces, but does not eliminate, these effects. This may be important in the genesis of ventricular arrhythmias in heart failure patients

Mobius domain-wall fermions on gradient-flowed dynamical HISQ ensembles

We report on salient features of a mixed lattice QCD action using valence Mobius domain-wall fermions solved on the dynamical N-f = 2 + 1 + 1 highly improved staggered quark sea- quark ensembles generated by the MILC Collaboration. The approximate chiral symmetry properties of the valence fermions are shown to be significantly improved by utilizing the gradient- flow scheme to first smear the highly improved staggered quark configurations. The greater numerical cost of the Mobius domain- wall inversions is mitigated by the highly efficient QUDA library optimized for NVIDIA GPU accelerated compute nodes. We have created an interface to this optimized QUDA solver in CHROMA. We provide tuned parameters of the action and performance of QUDA using ensembles with the lattice spacings a similar or equal to {0.15; 0.12; 0.09} fm and pion masses m(pi) similar or equal to {310; 220; 130} MeV. We have additionally generated two new ensembles with a similar to 0.12 fm and m(pi) similar to {400; 350} MeV. With a fixed flow time of t(gf) = 1 in lattice units, the residual chiral symmetry breaking of the valence fermions is kept below 10% of the light quark mass on all ensembles, m(res) less than or similar to 0.1 x m(l), with moderate values of the fifth dimension L-5 and a domain- wall height M-5 \u3c= 1.3. As a benchmark calculation, we perform a continuum, infinite volume, physical pion and kaon mass extrapolation of F-K +/-/F-pi +/- and demonstrate our results are independent of flow time and consistent with the FLAG determination of this quantity at the level of less than one standard deviation

Scale setting the M\"obius Domain Wall Fermion on gradient-flowed HISQ action using the omega baryon mass and the gradient-flow scales t0t_0 and w0w_0

We report on a sub-percent scale determination using the omega baryon mass and gradient-flow methods. The calculations are performed on 22 ensembles of $N_f=2+1+1$ highly improved, rooted staggered sea-quark configurations generated by the MILC and CalLat Collaborations. The valence quark action used is M\"obius Domain-Wall fermions solved on these configurations after a gradient-flow smearing is applied with a flowtime of $t_{\rm gf}=1$ in lattice units. The ensembles span four lattice spacings in the range $0.06 \lesssim a \lesssim 0.15$ fm, six pion masses in the range $130 \lesssim m_\pi \lesssim 400$ MeV and multiple lattice volumes. On each ensemble, the gradient-flow scales $t_0/a^2$ and $w_0/a$ and the omega baryon mass $a m_\Omega$ are computed. The dimensionless product of these quantities is then extrapolated to the continuum and infinite volume limits and interpolated to the physical light, strange and charm quark mass point in the isospin limit, resulting in the determination of $\sqrt{t_0}=0.1422(14)$ fm and $w_0 = 0.1709(11)$ fm with all sources of statistical and systematic uncertainty accounted for. The dominant uncertainty in this result is the stochastic uncertainty, providing a clear path for a few-per-mille uncertainty, as recently obtained by the Budapest-Marseille-Wuppertal Collaboration.Comment: v3: Published version; v2: Added determination of t_0 as well as w_0; v1: 13 pages plus appendices. The correlation function data, mass results and analysis code accompanying this publication can be found at this github repository: https://github.com/callat-qcd/project_scale_setting_mdwf_his

Detailed analysis of excited state systematics in a lattice QCD calculation of gAg_A

Excited state contamination remains one of the most challenging sources of systematic uncertainty to control in lattice QCD calculations of nucleon matrix elements and form factors. Most lattice QCD collaborations advocate for the use of high-statistics calculations at large time separations ($t_{\rm sep}\gtrsim1$ fm) to combat the signal-to-noise degradation. In this work we demonstrate that, for the nucleon axial charge, $g_A$, the alternative strategy of utilizing a large number of relatively low-statistics calculations at short to medium time separations ($0.2\lesssim t_{\rm sep}\lesssim1$ fm), combined with a multi-state analysis, provides a more robust and economical method of quantifying and controlling the excited state systematic uncertainty, including correlated late-time fluctuations that may bias the ground state. We show that two classes of excited states largely cancel in the ratio of the three-point to two-point functions, leaving the third class, the transition matrix elements, as the dominant source of contamination. On an $m_\pi\approx310$ MeV ensemble, we observe the expected exponential suppression of excited state contamination in the Feynman-Hellmann correlation function relative to the standard three-point function; the excited states of the regular three-point function reduce to the 1% level for $t_{\rm sep} >2$ fm while, for the Feynman-Hellmann correlation function, they are suppressed to 1% at $t_{\rm sep}\approx1$ fm. Independent analyses of the three-point and Feynman-Hellmann correlators yield consistent results for the ground state. However, a combined analysis allows for a more detailed and robust understanding of the excited state contamination, improving the demonstration that the ground state parameters are stable against variations in the excited state model, the number of excited states, and the truncation of early-time or late-time numerical data.Comment: v1: 13 pages plus appendices. The correlation function data and analysis code accompanying this publication can be accessed at this github repository: https://github.com/callat-qcd/project_fh_vs_3p