Factors associated with the continuum of care of HIV infected patients in Belgium

BREACHinfo:eu-repo/semantics/nonPublishe

Modafinil restores memory performance and neural activity impaired by sleep deprivation in mice.

The original aims of our study have been to investigate in sleep-deprived mice, the effects of modafinil administration on spatial working memory, in parallel with the evaluation of neural activity level, as compared to non-sleep-deprived animals. For this purpose, an original sleep deprivation apparatus was developed and validated with continuous electroencephalography recording. Memory performance was evaluated using spontaneous alternation in a T-maze, whereas the neural activity level was estimated by the quantification of the c-Fos protein in various cerebral zones. This study allowed altogether: First, to evidence that a diurnal 10-h sleep deprivation period induced an impairment of spatial working memory. Second, to observe a decrease in c-Fos expression after sleep deprivation followed by a behavioural test, as compared to non-sleep-deprived mice. This impairment in neural activity was evidenced in areas involved in wake-sleep cycle regulation (anterior hypothalamus and supraoptic nucleus), but also in memory (frontal cortex and hippocampus) and emotions (amygdala). Finally, to demonstrate that modafinil 64 mg/kg is able to restore on the one hand memory performance after a 10-h sleep deprivation period, and on the other hand, the neural activity level in the very same brain areas where it was previously impaired by sleep deprivation and cognitive task

Effect of cardiac resynchronization therapy on functional mitral regurgitation in heart failure.

Cardiac resynchronization therapy (CRT) reduces functional mitral regurgitation (MR) at rest. This study assessed exercise-induced changes in MR in patients with heart failure who were helped by CRT. The determinants of these exercise-induced changes in MR were analyzed in asynchronous and resynchronized left ventricles

The Use of Hydrogel Dressings in Sulfur Mustard-Induced Skin and Ocular Wound Management

Over one century after its first military use on the battlefield, sulfur mustard (SM) remains a threatening agent. Due to the absence of an antidote and specific treatment, the management of SM-induced lesions, particularly on the skin and eyes, still represents a challenge. Current therapeutic management is mainly limited to symptomatic and supportive care, pain relief, and prevention of infectious complications. New strategies are needed to accelerate healing and optimize the repair of the function and appearance of damaged tissues. Hydrogels have been shown to be suitable for healing severe burn wounds. Because the same gravity of lesions is observed in SM victims, hydrogels could be relevant dressings to improve wound healing of SM-induced skin and ocular injuries. In this article, we review how hydrogel dressings may be beneficial for improving the wound healing of SM-induced injuries, with special emphasis placed on their suitability as drug delivery devices on SM-induced skin and ocular lesions

Les biomarqueurs de l’intoxication par l’ypérite

International audienceSulfur mustard is a chemical warfare agent that damages the eyes, lungs and skin. In the latter, it induces severeburns that classify it as vesicant agents. Highly reactive, sulfur mustard has the ability to alkylate many biomolecules.The products derived from these reactions can be used, mainly using analytical chemistry methods, as biomarkersof exposure or effect. Sulfur mustard also greatly disrupts metabolism and protein induction. These responsescan be used to highlight longer-term effects.L’ypérite est un toxique de guerre endommageant les yeux, les poumons et la peau. Dans cette dernière, elle induitde graves brûlures qui la classent parmi les agents vésicants. Très réactive, elle possède des capacités d’alkylationde nombreuses biomolécules. Les produits qui en dérivent peuvent être utilisés, principalement en employantdes méthodes de chimie analytique, comme biomarqueurs d’exposition ou d’effet. L’ypérite perturbe égalementfortement le métabolisme et l’induction de protéines. Ces réponses sont utilisables pour mettre en évidencedes effets à plus long terme

Afterload mismatch revealed by an exercise biphasic response in aortic stenosis

peer reviewe