Mitral valve infective endocarditis following device occlusion of a coronary artery fistula

A three year old girl, with a right coronary artery fistula and signs of a hyperdynamic circulation, underwent uncomplicated closure of the fistula using an occluding device introduced via the femoral arterial route and covered with appropriate antibiotics. Two months later she presented with a persistent fever, signs of infective endocarditis (IE) and embolic phenomena in the left lower limb. Mitral valve endocarditis was confirmed immediately and treated effectively. However, initial ultrasound and doppler did not show the femoral artery thrombo-occlusion that was only confirmed on magnetic resonance angiography (MRA) one month later. This case highlights the usefulness of MRA in diagnosing suspected vessel occlusion in young children, and is in keeping with the latest NICE guidelines that suggest that prophylactic antibiotics do not always prevent IE. Parent and patient education on ‘what to look out for’, combined with careful clinical vigilance is paramount in the early detection of IE with a consequent reduction in morbidity and mortality.peer-reviewe

Describing and verifying FFT circuits using SharpHDL

Fourier transforms are critical in a variety of fields but in the past, they were rarely used in applications because of the big processing power required. However, the Cooley’s and Tukey’s development of the Fast Fourier Transform (FFT) vastly simplified this. A large number of FFT algorithms have been developed, amongst which are the radix-2 and the radix-22 . These are the ones that have been mostly used for practical applications due to their simple structure with constant butterfly geometry. Most of the research to date for the implementation and benchmarking of FFT algorithms have been performed using general purpose processors, Digital Signal Processors (DSPs) and dedicated FFT processor ICs but as FPGAs have developed they have become a viable solution for computing FFTs. In this paper, SharpHDL, an object oriented HDL, will be used to implement the two mentioned FFT algorithms and test their equivalence.peer-reviewe

Retrospective audit of active surveillance practice in favourable risk prostate cancer in a local patient cohort

BACKGROUND: The aim of this audit is to review the local monitoring of favourable risk prostate cancer (CaP) patients under active surveillance (AS), the primary endpoints being determining cancer-specific survival (CSS), rate of development of metastatic disease, mortality and percentage of patients who required definitive treatment.METHODS: Men diagnosed with CaP between January 2010 and December 2015 who were candidates for AS were included. Prostate specific antigen (PSA) values, imaging and histology results were recorded. The standard used is European Association of Urology 2021 guideline on AS and landmark papers published in the past decade.RESULTS: 56.3% of patients had biochemical, radiological or histological progression. Overall survival is 85.4%. CSS is 97.9%. Mortality is 2.1%, whilst 4.2% of patients developed metastatic disease. From the audited population, 36.4% eventually required radical treatment. There is a statistically significant difference between the vital status groups’ PSA level at diagnosis (p=0.002), PSA velocity (p=0.0001) and PSA density (p=0.029). The mean length of follow-up is 6.33years.CONCLUSION: The high CSS rate is testimony to the success of local AS programs. The wide range of cancer stage, grade and PSA levels of patients chosen for AS should raise the question of whether our selection criteria for AS are stringent enough.peer-reviewe

INFLUENCE OF VAPORIZATION AND IMPREGNATION OF SILVER NANOPARTICLES ON THE DRYING RATE OF Eucalyptus pellita F. MUELL.

The aim of this study was to evaluate the effect of vaporization and impregnation of silver nanoparticles on the Eucalyptus pellita wood properties. For that, samples of three radial regions of the wood from three trees were vaporized for 12 and 24 hours and later on, they were immersed in solution of silver nanoparticles with and without application of vacuum (750 mm.Hg). Anatomical, physical and chemical analyzes of the wood were carried out in order to evaluate the effect of the treatments. The drying rate of the wood was determined in moisture bands before and after the fiber saturation point. Generally, the treatments did not modify the anatomical characteristics, permeability, and wood density in the three radial regions; however, the vaporization for 24h reduced the total extractive content in the wood. These results contributed in obtaining gains in the drying rate before and after the fiber saturation point. The effect of impregnation of nanoparticles with vacuum preceded by two periods of vaporization resulted in higher drying rates and the time of 24h stood out, resulting in the best averages among all treatments. The impregnation of nanoparticles had positive effects on the drying rate

Stellar kinematics of dwarf galaxies from multi-epoch spectroscopy: application to Triangulum II

We present new MMT/Hectochelle spectroscopic measurements for 257 stars observed along the line of sight to the ultra-faint dwarf galaxy Triangulum II. Combining with results from previous Keck/DEIMOS spectroscopy, we obtain a sample that includes 16 likely members of Triangulum II, with up to 10 independent redshift measurements per star. To this multi-epoch kinematic data set we apply methodology that we develop in order to infer binary orbital parameters from sparsely sampled radial velocity curves with as few as two epochs. For a previously-identified (spatially unresolved) binary system in Tri~II, we infer an orbital solution with period $296.0_{-3.3}^{+3.8} \rm~ days$ , semi-major axis $1.12^{+0.41}_{-0.24}\rm~AU$, and a systemic velocity $-380.0 \pm 1.7 \rm~km ~s^{-1}$ that we then use in the analysis of Tri~II's internal kinematics. Despite this improvement in the modeling of binary star systems, the current data remain insufficient to resolve the velocity dispersion of Triangulum II. We instead find a 95% confidence upper limit of $\sigma_{v} \lesssim 3.4 \rm ~km~s^{-1}$

MAREA PROJECT : MEDISEH (Mediterranean Sensitive Habitats) specific contract no 2 (SI2.600741)

Based on the following Terms of Reference (TOR) of the content of the European Commission DG MARE request Ares (2011)665688: “Compile information supporting the identification and location of nursery areas (juveniles in their first and, if appropriate, second year of life) and spawning aggregations. This information, which is to be collated and archived in formats adequate for GIS rendering, shall refer to all the demersal and small pelagic species in the Mediterranean included in Appendix VII of Council Regulation (EC) No 199/2008 as well as for the species subject to minimum size (Council Regulation (EC) No 1967/2006-Annex III). In addition, ecological characterisation of these areas, both in terms of biological community (assemblage) and habitats therein, must be provided.” The technical tender form of the Specific Contract 2 (MEDISEH) defined the following objectives: Review of historical and current data on the locations and the status of seagrass beds, coralligenous and mäerl beds in different GSAs (Geographical Sub-Areas amending amending the Resolution GFCM/31/2007/2) all over the Mediterranean basin. Transform the information into a digitilized format within the framework of a geodatabase Review and map of all existing specific Marine Protected Areas (MPAs) in the Mediterranean area as well as areas that are under any form of national or international regulation. Identify and map suitable areas for Posidonia, coralligenous and mäerl communities by developing habitat distribution models at different spatial scales. Review and map all existing information on historical and current data of nurseries and spawning grounds of certain small pelagic (i.e., Engraulis encrasicolus, Sardina pilchardus, Scomber spp., Trachurus spp.) and demersal species (i.e., Aristaeomorpha foliacea, Aristeus antennatus, Merluccius merluccius, Mullus barbatus, Mullus surmuletus, Nephrops norvegicus, Parapenaeus longirostris, Pagellus erythrinus, Galeus melastomus, Raja clavata, Illex coindetti, Eledone cirrosa) that are included in the Data Collection Framework for the Mediterranean and subjected to minimum landing size based on Council Regulation No 1967/2006-Annex II. Analyze existing survey data and apply spatial analysis techniques in order to identify locations that are more likely to be density hot spot areas or are being more suitable for fish nurseries and spawning grounds for Engraulis encrasicolus, Sardina pilchardus, Scomber spp., Trachurus trachurus, Aristaeomorpha foliacea, Aristeus antennatus, Merluccius merluccius, Mullus barbatus, Mullus surmuletus, Nephrops norvegicus, Parapenaeus longirostris, Pagellus erythrinus, Galeus melastomus, Raja clavata, Illex coindetti, Eledone cirrosa These areas will also be characterized from an environmental and ecological perspective upon data availability. Integrate and present the aforementioned information through a Web-based GIS viewer with an associated geo-referenced database that will operate as a consulting tool for spatial management and conservation planning. Following the revision of the knowledge base, to identify gaps and suggest future research priorities. In order to meet these objectives, an expert team was composed within the MAREA Consortium from scientists with established expertise in the different topics required, and working in different areas of the Mediterranean basin. The team formed to execute the project includes the main Institutes of EU countries in the Mediterranean, all having solid reputations in the fields covered. The participating Institutes/Entities operate in the Western, Central and Eastern parts of the Mediterranean basin, and this ensures familiarity with the geographical areas that are related to the specific tendering. Moreover, a large number of scientists outside of the MAREA Consortium collaborated on a volunteer basis with data and other input. Details on the list of experts and external collaborators can be found in each Work Package in the present report. For CV details, check the MAREA expert web-site http://www.mareaproject.net/.peer-reviewe

Seagrass meadows (Posidonia oceanica) distribution and trajectories of change.

Posidonia oceanica meadows are declining at alarming rates due to climate change and human activities. Although P. oceanica is considered the most important and well-studied seagrass species of the Mediterranean Sea, to date there has been a limited effort to combine all the spatial information available and provide a complete distribution of meadows across the basin. The aim of this work is to provide a fine-scale assessment of (i) the current and historical known distribution of P. oceanica, (ii) the total area of meadows and (iii) the magnitude of regressive phenomena in the last decades. The outcomes showed the current spatial distribution of P. oceanica, covering a known area of 1,224,707 ha, and highlighted the lack of relevant data in part of the basin (21,471 linear km of coastline). The estimated regression of meadows amounted to 34% in the last 50 years, showing that this generalised phenomenon had to be mainly ascribed to cumulative effects of multiple local stressors. Our results highlighted the importance of enforcing surveys to assess the status and prioritize areas where cost-effective schemes for threats reduction, capable of reversing present patterns of change and ensuring P. oceanica persistence at Mediterranean scale, could be implemented.This study was supported and financed by the Commission of the European Union (DG MARE) within the MAREA Framework contract (Call for tenders MARE/2009/05_Lot1) through the Specific Project MEDISEH (SI2.600741): Mediterranean Sensitive Habitats, that received 568.996 euro. The opinions expressed are those of the authors of the study only and do not represent the Commission’s official position. The European Commission is thankfully acknowledged.This is the final version of the article. It first appeared from NPG via http://dx.doi.org/10.1038/srep1250

Ambiguous alliance : neutrality, opt-outs, and European defence

• EU member states that are neutral or militarily non-aligned, or that have an opt-out from common defence, are often overlooked in discussions about European defence. • The existence of these special status states not only creates uncertainty about the EU’s ambitions to become a fully fledged defence union but also calls into question the functionality of the mutual defence clause, Article 42.7, in the long run. • The special status states fall into three groups according to the challenges they pose to the EU: the “non-aligned in name only” (Finland and Sweden); the “odd one out” (Denmark); and the “strategic schnorrers” (Austria, Ireland, and Malta). • The EU’s work on its Strategic Compass should include debates on the special status states’ future role in European defence, as well as discussions on the operationalisation of the union’s mutual defence clause.peer-reviewe