124 research outputs found
Responses of dominant marsh macrophytes to inundation and disturbance and assessing marsh ecosystem services
Within two hydrodynamically different inundation regimes in North Carolina, the growth response and interactions of two dominant marsh macrophytes were evaluated over a range of inundation periods to understand better how coastal marshes will respond to rising sea levels. Marsh vegetation is likely key to accretion processes. Greater aboveground biomass baffles floodwaters, potentially increasing sedimentation, and greater belowground biomass contributes directly to the elevation of marsh substrate. Multi-level planters were used to evaluate experimentally the response of Spartina alterniflora Loisel and Juncus roemerianus Scheele to an array of inundation periods. Groundcover changes were evaluated before and after a pulsed disturbance to simulate conditions where these species are naturally delineated on the marsh platform. Peak production of S. alterniflora and J. roemerianus occurred at inundation periods of 0.5 to 14% and 0.4 to 28%, respectively, in marsh planters. The growth response patterns of S. alterniflora and J. roemerianus to inundation period were similar, although J. roemerianus appeared to experience greater stress in an astronomically-dominated than in a meteorologically-dominated inundation regime. Spartina alterniflora was found to be more resilient to disturbance than J. roemerianus in planters and on the marsh platform. Sixteen months following a one-time cutting disturbance, a significant decline in J. roemerianus and encroachment of S. alterniflora in experimental platform plots was observed within both regimes. Estuarine inundation appears to function as both a subsidy and stressor to marsh macrophytes. I propose a conceptual model to describe this relationship. ĂÂ ĂÂ The scaling of the losses and gains in marsh ecosystem services is reviewed within the context of coastal marsh habitat injury, restoration and creation as achieved by the Natural Resource Damage Assessment and compensatory restoration processes. An analysis into the current methods used to assess ecosystem services found that U.S. statutes provide for the compensation of loss of public trust resources, yet current metrics for ecosystem services serve as incomplete proxies of ecosystem function and condition. Coastal ecosystems have and will transgress in response to rising sea levels. Data from this investigation suggest that marsh accretion is challenged by increased inundation rates, especially where sediment supplies are limiting, thus, highlighting the need for accommodating transgression within the coastal zone.ĂÂ ĂÂ Ph.D
Anomalously High Recruitment of the 2010 Gulf Menhaden (Brevoortia patronus) Year Class: Evidence of Indirect Effects from the Deepwater Horizon Blowout in the Gulf of Mexico
Gulf menhaden (Brevoortia patronus) exhibited unprecedented juvenile recruitment in 2010 during the year of the Deepwater Horizon well blowout, exceeding the prior 39-year mean by more than four standard deviations near the Mississippi River. Abundance of that cohort remained exceptionally high for two subsequent years as recruits moved into older age classes. Such changes in this dominant forage fish population can be most parsimoniously explained as consequences of release from predation. Contact with crude oil induced high mortality of piscivorous seabirds, bottlenose dolphin (Tursiops truncatus), waders, and other fish-eating marsh birds, all of which are substantial consumers of Gulf menhaden. Diversions of fresh water from the Mississippi River to protect coastal marshes from oiling depressed salinities, impairing access to juvenile Gulf menhaden by aquatic predators that avoid low-salinity estuarine waters. These releases from predation led to an increase of Gulf menhaden biomass in 2011 to 2.4 million t, or more than twice the average biomass of 1.1 million t for the decade prior to 2010. Biomass increases of this magnitude in a major forage fish species suggest additional trophically linked effects at the population-, trophic-level and ecosystem scales, reflecting an heretofore little appreciated indirect effect that may be associated with major oil spills in highly productive marine waters
An intranasal live-attenuated SARS-CoV-2 vaccine limits virus transmission
The development of effective SARS-CoV-2 vaccines has been essential to control COVID-19, but significant challenges remain. One problem is intramuscular administration, which does not induce robust mucosal immune responses in the upper airwaysâthe primary site of infection and virus shedding. Here we compare the efficacy of a mucosal, replication-competent yet fully attenuated virus vaccine, sCPD9-ÎFCS, and the monovalent mRNA vaccine BNT162b2 in preventing transmission of SARS-CoV-2 variants B.1 and Omicron BA.5 in two scenarios. Firstly, we assessed the protective efficacy of the vaccines by exposing vaccinated male Syrian hamsters to infected counterparts. Secondly, we evaluated transmission of the challenge virus from vaccinated and subsequently challenged male hamsters to naĂŻve contacts. Our findings demonstrate that the live-attenuated vaccine (LAV) sCPD9-ÎFCS significantly outperformed the mRNA vaccine in preventing virus transmission in both scenarios. Our results provide evidence for the advantages of locally administered LAVs over intramuscularly administered mRNA vaccines in preventing infection and reducing virus transmission
Significance of E-lesions in Hodgkin lymphoma and the creation of a new consensus definition:a report from SEARCH
The International Staging Evaluation and Response Criteria Harmonization for Childhood, Adolescent, and Young Adult Hodgkin Lymphoma (SEARCH for CAYAHL) seeks to provide an appropriate, universal differentiation between E-lesions and stage IV extranodal disease in Hodgkin lymphoma (HL). A literature search was performed through the PubMed and Google Scholar databases using the terms âHodgkin disease,â and âextranodal,â âextralymphatic,â âE lesions,â âE stage,â or âE disease.â Publications were reviewed for the number of participants; median age and age range; diagnostic modalities used for staging; and the definition, incidence, and prognostic significance of E-lesions. Thirty-six articles describing 12 640 patients met the inclusion criteria. Most articles reported staging per the Ann Arbor (72%, 26/36) or Cotswolds modification of the Ann Arbor staging criteria (25%, 9/36), and articles rarely defined E-lesions or disambiguated âextranodal disease.â The overall incidence of E-lesions for patients with stage I-III HL was 11.5% (1330/11 602 unique patients). Available stage-specific incidence analysis of 3888 patients showed a similar incidence of E-lesions in stage II (21.2%) and stage III (21.9%), with E-lesions rarely seen with stage I disease (1.1%). E-lesions likely remain predictive, but we cannot unequivocally conclude that identifying E-lesions in HL imparts prognostic value in the modern era of the more selective use of targeted radiation therapy. A harmonized E-lesion definition was reached based on the available evidence and the consensus of the SEARCH working group. We recommend that this definition of E-lesion be applied in future clinical trials with explicit reporting to confirm the prognostic value of E-lesions.</p
Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters
Vaccines play a critical role in combating the COVID-19 pandemic. Future control of the pandemic requires improved vaccines with high efficacy against newly emerging SARS-CoV-2 variants and the ability to reduce virus transmission. Here we compare immune responses and preclinical efficacy of the mRNA vaccine BNT162b2, the adenovirus-vectored spike vaccine Ad2-spike and the live-attenuated virus vaccine candidate sCPD9 in Syrian hamsters, using both homogeneous and heterologous vaccination regimens. Comparative vaccine efficacy was assessed by employing readouts from virus titrations to single-cell RNA sequencing. Our results show that sCPD9 vaccination elicited the most robust immunity, including rapid viral clearance, reduced tissue damage, fast differentiation of pre-plasmablasts, strong systemic and mucosal humoral responses, and rapid recall of memory T cells from lung tissue after challenge with heterologous SARS-CoV-2. Overall, our results demonstrate that live-attenuated vaccines offer advantages over currently available COVID-19 vaccines
A Transient Sub-Eddington Black Hole X-ray Binary Candidate in the Dust Lanes of Centaurus A
We report the discovery of a bright X-ray transient, CXOU J132527.6-430023,
in the nearby early-type galaxy NGC 5128. The source was first detected over
the course of five Chandra observations in 2007, reaching an unabsorbed
outburst luminosity of 1-2*10^38 erg/s in the 0.5-7.0 keV band before returning
to quiescence. Such luminosities are possible for both stellar-mass black hole
and neutron star X-ray binary transients. Here, we attempt to characterize the
nature of the compact object. No counterpart has been detected in the optical
or radio sky, but the proximity of the source to the dust lanes allows for the
possibility of an obscured companion. The brightness of the source after a >100
fold increase in X-ray flux makes it either the first confirmed transient
non-ULX black hole system in outburst to be subject to detailed spectral
modeling outside the Local Group, or a bright (>10^38 erg/s) transient neutron
star X-ray binary, which are very rare. Such a large increase in flux would
appear to lend weight to the view that this is a black hole transient. X-ray
spectral fitting of an absorbed power law yielded unphysical photon indices,
while the parameters of the best-fit absorbed disc blackbody model are typical
of an accreting ~10 Msol black hole in the thermally dominant state.Comment: 8 pages, 6 figures, accepted for publication in Ap
Exome sequencing identifies NBEAL2 as the causative gene for gray platelet syndrome.
Gray platelet syndrome (GPS) is a predominantly recessive platelet disorder that is characterized by mild thrombocytopenia with large platelets and a paucity of α-granules; these abnormalities cause mostly moderate but in rare cases severe bleeding. We sequenced the exomes of four unrelated individuals and identified NBEAL2 as the causative gene; it has no previously known function but is a member of a gene family that is involved in granule development. Silencing of nbeal2 in zebrafish abrogated thrombocyte formation
Marsh macrophyte responses to inundation anticipate impacts of sea-level rise and indicate ongoing drowning of North Carolina marshes
In situ persistence of coastal marsh habitat as sea level rises depends on whether macrophytes induce compensatory accretion of the marsh surface. Experimental planters in two North Carolina marshes served to expose two dominant macrophyte species to six different elevations spanning 0.75 m (inundation durations 0.4ĂąâŹâ99 %). Spartina alterniflora and Juncus roemerianus exhibited similar responsesĂąâŹâwith production in planters suggesting initial increases and then demonstrating subsequent steep declines with increasing inundation, conforming to a segment of the ecophysiological parabola. Projecting inundation levels experienced by macrophytes in the planters onto adjacent marsh platforms revealed that neither species occupied elevations associated with increasing production. Declining macrophyte production with rising seas reduces both bioaccumulation of roots below-ground and baffle-induced sedimentation above-ground. By occupying only descending portions of the parabola, macrophytes in central North Carolina marshes are responding to rising water levels by progressive declines in production, ultimately leading to marsh drowning
Sensory Communication
Contains table of contents for Section 2, an introduction and reports on twelve research projects.National Institutes of Health Grant R01 DC00117National Institutes of Health Grant R01 DC02032National Institutes of Health/National Institute of Deafness and Other Communication Disorders Grant 2 R01 DC00126National Institutes of Health Grant 2 R01 DC00270National Institutes of Health Contract N01 DC-5-2107National Institutes of Health Grant 2 R01 DC00100U.S. Navy - Office of Naval Research Grant N61339-96-K-0002U.S. Navy - Office of Naval Research Grant N61339-96-K-0003U.S. Navy - Office of Naval Research Grant N00014-97-1-0635U.S. Navy - Office of Naval Research Grant N00014-97-1-0655U.S. Navy - Office of Naval Research Subcontract 40167U.S. Navy - Office of Naval Research Grant N00014-96-1-0379U.S. Air Force - Office of Scientific Research Grant F49620-96-1-0202National Institutes of Health Grant RO1 NS33778Massachusetts General Hospital, Center for Innovative Minimally Invasive Therapy Research Fellowship Gran
Sensory Communication
Contains table of contents for Section 2, an introduction and reports on fifteen research projects.National Institutes of Health Grant RO1 DC00117National Institutes of Health Grant RO1 DC02032National Institutes of Health Contract P01-DC00361National Institutes of Health Contract N01-DC22402National Institutes of Health/National Institute on Deafness and Other Communication Disorders Grant 2 R01 DC00126National Institutes of Health Grant 2 R01 DC00270National Institutes of Health Contract N01 DC-5-2107National Institutes of Health Grant 2 R01 DC00100U.S. Navy - Office of Naval Research/Naval Air Warfare Center Contract N61339-94-C-0087U.S. Navy - Office of Naval Research/Naval Air Warfare Center Contract N61339-95-K-0014U.S. Navy - Office of Naval Research/Naval Air Warfare Center Grant N00014-93-1-1399U.S. Navy - Office of Naval Research/Naval Air Warfare Center Grant N00014-94-1-1079U.S. Navy - Office of Naval Research Subcontract 40167U.S. Navy - Office of Naval Research Grant N00014-92-J-1814National Institutes of Health Grant R01-NS33778U.S. Navy - Office of Naval Research Grant N00014-88-K-0604National Aeronautics and Space Administration Grant NCC 2-771U.S. Air Force - Office of Scientific Research Grant F49620-94-1-0236U.S. Air Force - Office of Scientific Research Agreement with Brandeis Universit
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