Pratique de la cryopréservation de tissu ovarien à Caen de 1997 à 2008 à partir de seize cas

CAEN-BU Médecine pharmacie (141182102) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Curage axillaire préparé par lipoaspiration dans les cancers du sein (à propos de 111 cas poitevins)

POITIERS-BU Médecine pharmacie (861942103) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Pronostic des mauvaises répondeuses en fécondation in vitro selon le protocole de stimulation ovarienne

CAEN-BU Médecine pharmacie (141182102) / SudocSudocFranceF

Prise en charge d'un couple en assistance médicale à la procréation (devenir du projet parental et facteurs pronostiques de réussite, expérience du centre d'AMP du CHU de Caen)

CAEN-BU Médecine pharmacie (141182102) / SudocSudocFranceF

Maturation cervicale par dinoprostone (comparaison de l'efficacité du dispositif intravaginal à 10mg selon la durée d'utilisation de 12 heures ou 24 heures )

CAEN-BU Médecine pharmacie (141182102) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Enoxaparin for prevention of unexplained recurrent miscarriage: a multicenter randomized double-blind placebo-controlled trial.

International audienceIt is common practice in many centers to offer antithrombotic medications to women with unexplained recurrent miscarriage, in the presence or absence of inherited thrombophilia. Although no benefit of aspirin vs placebo has been clearly demonstrated, a double-blind placebo-controlled trial on the effect of low-molecular-weight heparin is lacking. We enrolled 258 pregnant women with a history of unexplained recurrent miscarriage (≥2 consecutive miscarriages before 15 weeks' gestation) and a negative thrombophilia workup. They were randomly assigned to receive one daily subcutaneous injection of enoxaparin 40 mg or placebo until 35 weeks' gestation. We included 256 women (mean age 32 years, ≥3 miscarriages: 72%; mean gestational age 39 days of amenorrhea) in the intention-to-treat analysis; 66.6% of 138 who received enoxaparin had a live birth vs 72.9% of 118 who received placebo. The absolute difference was -6% (95% CI, -17.1 to 5.1), excluding a 10% increase in the rate of live-birth on enoxaparin (P = .34). In this first randomized, double-blind, placebo-controlled trial, enoxaparin (40 mg once daily) did not improve the chance of a live birth in nonthrombophilic women with unexplained recurrent miscarriage. This trial is registered at www.ClinicalTrials.gov as #NCT00740545 and the French National Health and Drug Safety Agency (EudraCT #2006-003350-18)