Brooklyn Trash Problems

Walk through the streets of New York and at some point you’ll inevitably pass by a wafting smell of garbage, but residents of North Brooklyn are handling more than their share of the smelly load and they’re tired of getting dumped on. A newly formed coalition of neighbors and environmental activists has begun a turf war against Brooklyn Transfer LLC, a waste transfer station located on Thames Street in East Williamsburg, which handles private commercial waste through ­­­­­­­­­­­­­Five Star Carting. Link to Map: https://www.zeemaps.com/map?group=176940

Segmented assimilation and mobility among men in the early 20th century

Background: Segmented assimilation theory asserts that children born to immigrants experience divergent paths of incorporation. While some exhibit substantial gains in well-being, others may fare worse than US-origin whites or their own parents. It is certainly true that contemporary immigrants find themselves living in a different context than those who arrived in the United States during the early 20th century. However, it remains an empirical question whether the incorporation process has suddenly become segmented. Methods: We select five of the top European sending regions to ask whether socioeconomic outcomes varied between immigrant-origin populations between 1910 and 1930. We use the Integrated Public Use Microdata Series Multigenerational Longitudinal Panel to link men over a 20-year period. Logistic regression is used to predict probabilities of school enrollment in 1910 among US- and immigrant-origin youths. We then rely on a series of OLS specifications to predict the socioeconomic standing of these men in 1930 as well as differences in father-son status. We also compare relative rates of occupational mobility across country of origin. Results: We find evidence of intergenerational mobility as well as convergence in economic success. Though some immigrant-origin groups fare better than others (e.g., the Irish and those from the United Kingdom versus Italians and Germans), our results largely align with classical theories of assimilation. To the extent that segmented assimilation occurs, it emerges in the especially low levels of attainment among German-origin youths. Contribution: Our findings raise important questions about studies that investigate segmented assimilation among immigrant-origin youths. We argue that more work is needed to determine whether downward assimilation is a sign of permanent disadvantage or a short-term consequence from which youths can recover

Extrauterine inflammatory myofibroblastic tumor: A case report

• This is the first case report of inflammatory myofibroblastic tumor in the literature to present with extrauterine disease. • A prompt work-up of symptoms may have precluded a tumor debulking procedure

Approximate Coupling Terms In Seismoelectric Theory: From Frequency Domain To Time Domain

International audienceElectro-kinetic coupling Porous media can be seen as a solid matrix containing gaps filled with fluid or gas. When these phases contain charge differences, the propagation of a seismic wave generates an electromagnetic wave. Indeed, the propagation of a mechanical wave agitates charged particles, which creates electrical current. Modeling seismoelectric effects A model of the coupling phenomenon was provided by Pride [1] that consists in coupling Maxwell's (electromagnetics) and Biot's (elastodynamics) equations followed by Pride and Haarsten [2] with a focus on electroseismic effects. These phenomena are inherently multi-scale. On the one hand, they arise from a coupling at a small scale. But, on the other, these seismic-wave-induced electromagnetic perturbations may occur at depths such as 300m underground. Features of the solution depend both on macro scale data such as scattering at geological layer interfaces and on micro scale coupling. This effect occurs in the Earth. If we take a look at the constitution of the Earth (sand/sandstone) at large scale we have seeds/pores that are charged in excess (usually negative) and when the wave propagates there is a fluid-solid motion transporting counterions that induces an electrical current.[1] Pride, S. R. (1994). Governing equations for the coupled electromagnetics and acoustics of porous media

Master\u27s Recital

List of performers and performances

In vitro synergistic anti-prion effect of cholesterol ester modulators in combination with chlorpromazine and quinacrine

Abstract Our studies on the role of cholesterol in prion infection/replication showed that brains and peripheral cells of sheep susceptible-to or suffering-from Scrapie were characterized by an altered cholesterol homeostasis, and that drugs affecting cholesterol ester pool were endowed with selective anti-prion activity in N2a cell lines infected with the 22L and RML prion strains. In these prion-infected N2a cell lines, we now report increased anti-prion activity of dual-drug combinations consisting of cholesterol ester modulators associated with prion inhibitors. Synergism was obtained with the cholesterol ester modulators everolimus, pioglitazone, progesterone, and verapamil associated with the anti-prion chlorpromazine, and with everolimus and pioglitazone associated with the anti-prion quinacrine. In addition, comparative lipid analyses in prion-infected vs. uninfected N2a cells, demonstrated a derangement of type and distribution of cholesterol ester, free cholesterol, and triglyceride pools in the infected cells. Single-drug treatments differently affected synthesis of the various lipid forms, whereas combined drug treatments appeared to restore a lipid profile similar to that of the untreated-uninfected cells. We conclude that the anti-prion synergistic effects of cholesterol ester modulators associated with the cholesterol-interfering anti-prion drugs chlorpromazine and quinacrine may arise from the ability of combined drugs to re-establish lipid homeostasis in the prion-infected cells. Overall, these data suggest that inhibition of prion replication can be readily potentiated by combinatorial drug treatments and that steps of cholesterol/cholesterol ester metabolism may represent suitable targets

Sensitivity of human pluripotent stem cells to insulin precipitation induced by peristaltic pump-based medium circulation: Considerations on process development

Controlled large-scale production of human pluripotent stem cells (hPSCs) is indispensable for their envisioned clinical translation. Aiming at advanced process development in suspension culture, the sensitivity of hPSC media to continuous peristaltic pump-based circulation, a well-established technology extensively used in hydraulically-driven bioreactors, was investigated. Unexpectedly, conditioning of low protein media (i.e. E8 and TeSR-E8) in a peristaltic pump circuit induced severe viability loss of hPSCs cultured as aggregates in suspension. Optical, biochemical, and cytological analyses of the media revealed that the applied circulation mode resulted in the reduction of the growth hormone insulin by precipitation of micro-sized particles. Notably, in contrast to insulin depletion, individual withdrawal of other medium protein components (i.e. bFGF, TGFβ1 or transferrin) provoked minor reduction of hPSC viability, if any. Supplementation of the surfactant glycerol or the use of the insulin analogue Aspart did not overcome the issue of insulin precipitation. In contrast, the presence of bovine or human serum albumin (BSA or HSA, respectively) stabilized insulin rescuing its content, possibly by acting as molecular chaperone-like protein, ultimately supporting hPSC maintenance. This study highlights the potential and the requirement of media optimization for automated hPSC processing and has broad implications on media development and bioreactor-based technologies. © 2017 The Author(s).Horizon 2020/Marie Skłodowska-Curie Individual Fellowship POSEIDONDFG/EXC/REBIRTHDFG/EXC62/3DFG/ZW64/4-1BMBF/13N12606BMBF/13N14086StemBANCCH2020/TECHNOBEATHannover Medical School internal program (HiLF)Joachim Herz Stiftun

Risk of spontaneous abortion and other pregnancy outcomes in 15–25 year old women exposed to human papillomavirus-16/18 AS04-adjuvanted vaccine in the United Kingdom

AbstractBackgroundWe assessed the risk of spontaneous abortion (SA) after inadvertent exposure to HPV-16/18-vaccine during pregnancy using an observational cohort design.MethodsThe study population included women aged 15–25 years registered with the Clinical Practice Research Datalink General Practice OnLine Database in the United Kingdom (UK), who received at least one HPV-16/18-vaccine dose between 1st September 2008 and 30th June 2011. Exposed women had the first day of gestation between 30 days before and 45 days (90 days for the extended exposure period) after any HPV-16/18-vaccine dose. Non-exposed women had the first day of gestation 120 days–18 months after the last dose. SA defined as foetal loss between weeks 1 and 23 of gestation (UK definition).ResultsThe frequency of SA was 11.6% (among 207 exposed) and 9.0% (632 non-exposed), women: hazard ratio (HR) adjusted for age at first day of gestation 1.30 (95% confidence interval: 0.79–2.12). Sensitivity analysis per number of doses administered (−30 to +45-day risk period) showed a HR for SA of 1.11 (0.64–1.91) for 18/178 women with one dose during the risk period versus 2.55 (1.09–5.93) in 6/29 women with two doses within a 4–5 weeks period. The proportion of pre-term/full-term/postterm deliveries, small/large for gestational age infants, and birth defects was not significantly different between exposed and non-exposed women. Results were consistent using a (United States) SA definition of foetal loss between weeks 1–19 and/or the extended risk period.ConclusionThere was no evidence of an increased risk of SA and other adverse pregnancy outcomes in young women inadvertently HPV-16/18-vaccinated around gestation. Nevertheless, women who are pregnant or trying to become pregnant are advised to postpone vaccination until completion of pregnancy

Differential manifestation of teacher self-efficacy in Brazilian university professors in the health area

Self-efficacy has occupied the research space due to the relevance it holds as an explanatory mechanism of human performance to understand the characteristics of the population, the study analyzed the differentiation of beliefs of self-efficacy of university professors who teach in the health area according to gender, marital status, age, seniority at work, religion and training graduate academic. A cross sectional and quantitative study was attended by 189 university professors working in a private university in northeastern Brazil. The differentiation indicate that Women perceive themselves more self-effective in the elaboration of didactic strategies to favor interaction in class; older teachers consider themselves more effective in didactic strategies for the planning of classes and postdoctoral teachers stood out for the higher sense of self-efficacy regarding didactic strategies for class planning, didactic strategies to actively implicate students and didactic strategies to favor interaction in class. Self-efficacy as an explanatory mechanism of human performance is determinant and therefore it is important to be enhanced in university professors for the pursuit of a higher quality of teaching-learning of future health professionals.info:eu-repo/semantics/publishedVersio