10,765 research outputs found
Discovery of TUG-770: a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes
Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist with favorable physicochemical and pharmacokinetic properties. The compound efficiently normalizes glucose tolerance in diet-induced obese mice, an effect that is fully sustained after 29 days of chronic dosing
Characterization of GaN Nanorods Fabricated Using Ni Nanomasking and Reactive Ion Etching: A Top-Down Approach
Large thermal mismatch between GaN surface and sapphire results in compressive stress in Gallium Nitride (GaN) layer which degrades the device performance. Nanostructuring the GaN can reduce this stress leading to reduction in Quantum Confined Stark Effect. Aligned GaN nanorods based nanodevices have potential applications in electronics and optoelectronics. This paper describes the fabrication of GaN nanorods using Ni nanomasking and reactive ion etching. The morphology of GaN nanorods was studied by field emission scanning electron microscopy. The optical properties of GaN nanorods were studied by Cathodoluminescence (CL) spectroscopy. CL results revealed the existence of characteristic band-edge luminescence and yellow band luminescence.
When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3099
Relativistic Landau Levels in the Rotating Cosmic String Spacetime
In the spacetime induced by a rotating cosmic string we compute the energy
levels of a massive spinless particle coupled covariantly to a homogeneous
magnetic field parallel to the string. Afterwards, we consider the addition of
a scalar potential with a Coulomb-type and a linear confining term and
completely solve the Klein-Gordon equations for each configuration. Finally,
assuming rigid-wall boundary conditions, we find the Landau levels when the
linear defect is itself magnetized. Remarkably, our analysis reveals that the
Landau quantization occurs even in the absence of gauge fields provided the
string is endowed with spin.Comment: Writing and grammar revised. References added. 14 pages, no figures.
To appear in European Phys. J.
Fracture strength and Young's modulus of ZnO nanowires
The fracture strength of ZnO nanowires vertically grown on sapphire
substrates was measured in tensile and bending experiments. Nanowires with
diameters between 60 and 310 nm and a typical length of 2 um were manipulated
with an atomic force microscopy tip mounted on a nanomanipulator inside a
scanning electron microscope. The fracture strain of (7.7 +- 0.8)% measured in
the bending test was found close to the theoretical limit of 10% and revealed a
strength about twice as high as in the tensile test. From the tensile
experiments the Young's modulus could be measured to be within 30% of that of
bulk ZnO, contrary to the lower values found in literature.Comment: 5 pages, 3 figures, 1 tabl
Complex Line Bundles over Simplicial Complexes and their Applications
Discrete vector bundles are important in Physics and recently found
remarkable applications in Computer Graphics. This article approaches discrete
bundles from the viewpoint of Discrete Differential Geometry, including a
complete classification of discrete vector bundles over finite simplicial
complexes. In particular, we obtain a discrete analogue of a theorem of Andr\'e
Weil on the classification of hermitian line bundles. Moreover, we associate to
each discrete hermitian line bundle with curvature a unique piecewise-smooth
hermitian line bundle of piecewise constant curvature. This is then used to
define a discrete Dirichlet energy which generalizes the well-known cotangent
Laplace operator to discrete hermitian line bundles over Euclidean simplicial
manifolds of arbitrary dimension
Plasmonic gold helices for the visible range fabricated by oxygen plasma purification of electron beam induced deposits
Electron beam induced deposition (EBID) currently provides the only direct writing technique for truly three-dimensional nanostructures with geometrical features below 50 nm. Unfortunately, the depositions from metal-organic precursors suffer from a substantial carbon content. This hinders many applications, especially in plasmonics where the metallic nature of the geometric surfaces is mandatory. To overcome this problem a post-deposition treatment with oxygen plasma at room temperature was investigated for the purification of gold containing EBID structures. Upon plasma treatment, the structures experience a shrinkage in diameter of about 18 nm but entirely keep their initial shape. The proposed purification step results in a core-shell structure with the core consisting of mainly unaffected EBID material and a gold shell of about 20 nm in thickness. These purified structures are plasmonically active in the visible wavelength range as shown by dark field optical microscopy on helical nanostructures. Most notably, electromagnetic modeling of the corresponding scattering spectra verified that the thickness and quality of the resulting gold shell ensures an optical response equal to that of pure gold nanostructures
The ensemble of random Markov matrices
The ensemble of random Markov matrices is introduced as a set of Markov or
stochastic matrices with the maximal Shannon entropy. The statistical
properties of the stationary distribution pi, the average entropy growth rate
and the second largest eigenvalue nu across the ensemble are studied. It is
shown and heuristically proven that the entropy growth-rate and second largest
eigenvalue of Markov matrices scale in average with dimension of matrices d as
h ~ log(O(d)) and nu ~ d^(-1/2), respectively, yielding the asymptotic relation
h tau_c ~ 1/2 between entropy h and correlation decay time tau_c = -1/log|nu| .
Additionally, the correlation between h and and tau_c is analysed and is
decreasing with increasing dimension d.Comment: 12 pages, 6 figur
Nonlinearity-induced conformational instability and dynamics of biopolymers
We propose a simple phenomenological model for describing the conformational
dynamics of biopolymers via the nonlinearity-induced buckling and collapse
(i.e. coiling up) instabilities. Taking into account the coupling between the
internal and mechanical degrees of freedom of a semiflexible biopolymer chain,
we show that self-trapped internal excitations (such as amide-I vibrations in
proteins, base-pair vibrations in DNA, or polarons in proteins) may produce the
buckling and collapse instabilities of an initially straight chain. These
instabilities remain latent in a straight infinitely long chain, because the
bending of such a chain would require an infinite energy. However, they
manifest themselves as soon as we consider more realistic cases and take into
account a finite length of the chain. In this case the nonlinear localized
modes may act as drivers giving impetus to the conformational dynamics of
biopolymers. The buckling instability is responsible, in particular, for the
large-amplitude localized bending waves which accompany the nonlinear modes
propagating along the chain. In the case of the collapse instability, the chain
folds into a compact three-dimensional coil. The viscous damping of the aqueous
environment only slows down the folding of the chain, but does not stop it even
for a large damping. We find that these effects are only weakly affected by the
peculiarities of the interaction potentials, and thus they should be generic
for different models of semiflexible chains carrying nonlinear localized
excitations.Comment: 4 pages (RevTeX) with 5 figures (EPS
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