Discovery of TUG-770: a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes

Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist with favorable physicochemical and pharmacokinetic properties. The compound efficiently normalizes glucose tolerance in diet-induced obese mice, an effect that is fully sustained after 29 days of chronic dosing

Derivation of diagnostic models based on formalized process knowledge

© IFAC.Industrial systems are vulnerable to faults. Early and accurate detection and diagnosis in production systems can minimize down-time, increase the safety of the plant operation, and reduce manufacturing costs. Knowledge- and model-based approaches to automated fault detection and diagnosis have been demonstrated to be suitable for fault cause analysis within a broad range of industrial processes and research case studies. However, the implementation of these methods demands a complex and error-prone development phase, especially due to the extensive efforts required during the derivation of models and their respective validation. In an effort to reduce such modeling complexity, this paper presents a structured causal modeling approach to supporting the derivation of diagnostic models based on formalized process knowledge. The method described herein exploits the Formalized Process Description Guideline VDI/VDE 3682 to establish causal relations among key-process variables, develops an extension of the Signed Digraph model combined with the use of fuzzy set theory to allow more accurate causality descriptions, and proposes a representation of the resulting diagnostic model in CAEX/AutomationML targeting dynamic data access, portability, and seamless information exchange

Preliminary evaluation of radar imagery of Yellowstone Park, Wyoming

Evaluation of radar imagery of Yellowstone Park, Wyomin

Hypervelocity Impact of Composite Overwrap Pressure Vessels

There is a limited amount of hypervelocity impact (HVI) data on pressurized composite overwrapped pressure vessels (COPV). In recent years, NASA has performed HVI tests to characterize impact conditions resulting in either leak or burst of the COPVs representative of spacecraft hardware. This paper reports on the results of 40 tests that have been conducted on several types of COPV configurations, pressurized by inert gas to near the vessels rated maximum expected operating pressure (MEOP). These tests were used to better understand COPV response under HVI conditions and develop ballistic limit equations (BLE) related to these tests

Identification and Distribution of the Treefrogs Hyla versicolor and Hyla chrysoscelis in Iowa

Historically, the tetraploid and diploid species pair of gray treefrogs, Hyla versicolor and Hyla chrysoscelis, were mapped collectively in Iowa because no macroscopic morphological characteristics useful in recognizing the two species had been found. The present study reports identification and separation of the species by counts of nucleoli in the palpebral membrane of the eye and by measurement of scanning electron micrographs of toepad epithelial projections. Subsequent morphometric data confirm that the two species are morphologically distinct in Iowa but that overlap in characters continues to make macroscopic morphology unreliable for identifying individuals. H. chrysoscelis is distributed sporadically though all but the northeastern quarter of Iowa, while H. versicolor is found roughly southeast of a diagonal line extending from the northeastern to the southwestern corner of the state. A genetically different population appears to reside in Cherokee Co. Iowa

Solving Problems Caused by Small Micrometeoroid and Orbital Debris Impacts for Space-Walking Astronauts

No abstract availabl

IADC Vulnerability Report, IT32-21

Numerous mission support hardware systems and their spares are maintained outside of the habitable volume of the International Space Station (ISS), and are arranged covered by a multi-layer insulation (MLI) thermal blanket which provides both thermal control and a measure of protection from micrometeoroids and orbital debris (MMOD). The NASA Hypervelocity Impact Technology (HVIT) group at the Johnson Space Center in Houston Texas has assessed the protection provided by MLI in a series of hypervelocity impact tests using a 1 mm thick aluminum 6061-T6 rear wall to simulate the actual hardware behind the MLI. HVIT has also evaluated methods to enhance the protection provided by MLI thermal blankets. The impact study used both aluminum and steel spherical projectiles accelerated to speeds of 7 km/s using a 4.3 mm, two-stage, light-gas gun at the NASA White Sands Test Facility (WSTF)

IADC Vulnerability Report, IT32-13

This section provides hypervelocity impact test data for two types of batteries: Lithium-Ion (Li-Ion) and Nickel Hydrogen (Ni-H2) batteries. The impact tests were directed by the NASA Johnson Space Center Hypervelocity Impact Technology (HVIT) group in Houston Texas, and were performed at the NASA White Sands Test Facility (WSTF)

Ballistic Performance Model of Crater Formation in Monolithic, Porous Thermal Protection Systems

Porous monolithic ablative systems insulate atmospheric reentry vehicles from reentry plasmas generated by atmospheric braking from orbital and exo-orbital velocities. Due to the necessity that these materials create a temperature gradient up to several thousand Kelvin over their thickness, it is important that these materials are near their pristine state prior to reentry. These materials may also be on exposed surfaces to space environment threats like orbital debris and meteoroids leaving a probability that these exposed surfaces will be below their prescribed values. Owing to the typical small size of impact craters in these materials, the local flow fields over these craters and the ablative process afford some margin in thermal protection designs for these locally reduced performance values. In this work, tests to develop ballistic performance models for thermal protection materials typical of those being used on Orion are discussed. A density profile as a function of depth of a typical monolithic ablator and substructure system is shown in Figure 1a

Scaling K2. I. Revised Parameters for 222,088 K2 Stars and a K2 Planet Radius Valley at 1.9 R_⊕

Previous measurements of stellar properties for K2 stars in the Ecliptic Plane Input Catalog largely relied on photometry and proper motion measurements, with some added information from available spectra and parallaxes. Combining Gaia DR2 distances with spectroscopic measurements of effective temperatures, surface gravities, and metallicities from the Large Sky Area Multi-Object Fibre Spectroscopic Telescope (LAMOST) DR5, we computed updated stellar radii and masses for 26,838 K2 stars. For 195,250 targets without a LAMOST spectrum, we derived stellar parameters using random forest regression on photometric colors trained on the LAMOST sample. In total, we measured spectral types, effective temperatures, surface gravities, metallicities, radii, and masses for 222,088 A, F, G, K, and M-type K2 stars. With these new stellar radii, we performed a simple reanalysis of 299 confirmed and 517 candidate K2 planet radii from Campaigns 1–13, elucidating a distinct planet radius valley around 1.9 R_⊕, a feature thus far only conclusively identified with Kepler planets, and tentatively identified with K2 planets. These updated stellar parameters are a crucial step in the process toward computing K2 planet occurrence rates