Discovery of TUG-770: a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes

Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist with favorable physicochemical and pharmacokinetic properties. The compound efficiently normalizes glucose tolerance in diet-induced obese mice, an effect that is fully sustained after 29 days of chronic dosing

Lake Ohrid ENSIS database Technical report

Import of measurements to ENSIS. Examples of how ENSIS can be used. Detailed import instruction

Hypervelocity Impact of Composite Overwrap Pressure Vessels

There is a limited amount of hypervelocity impact (HVI) data on pressurized composite overwrapped pressure vessels (COPV). In recent years, NASA has performed HVI tests to characterize impact conditions resulting in either leak or burst of the COPVs representative of spacecraft hardware. This paper reports on the results of 40 tests that have been conducted on several types of COPV configurations, pressurized by inert gas to near the vessels rated maximum expected operating pressure (MEOP). These tests were used to better understand COPV response under HVI conditions and develop ballistic limit equations (BLE) related to these tests

BOTPPI, a New Wittig Salt Used in the Synthesis of 12-(S)-Hydroxy-Eicosatetraenoic Acid [12-(S)-HETE]

An efficient route to (Z)-(8-benzyloxy-8-oxooct-3-en-1-yl)triphenylphosphonium iodide, or BOTPPI, is disclosed, complete with full experimental details, NMR spectra, and HRMS data. BOTPPI serves as a surrogate for (Z)-(8-methoxy-8-oxooct-3-en-1-yl)triphenylphosphonium iodide, or MOTPPI, a Wittig salt previously used in two 12-HETE syntheses. BOTPPI has the advantage over MOTPPI of being derived from a sequence for which every intermediate is UV-active and amenable to large-scale chromatographic purification. A formal asymmetric total synthesis of 12-(S)-HETE is also reported, involving a stereoselective phase-transfer catalyzed (PTC) alkylation in its key step

Five New Species of Orchesella (Collembola: Entomobryidae)

This paper describes 5 species of the genus Orchesella (Collembola: Entomobryidae) new to science. The chaetotaxy of the abdomen as well as the antennal pin seta are used systematically for the first time in the taxonomy of the genus

Theory of Activated Transport in Bilayer Quantum Hall Systems

We analyze the transport properties of bilayer quantum Hall systems at total filling factor $\nu=1$ in drag geometries as a function of interlayer bias, in the limit where the disorder is sufficiently strong to unbind meron-antimeron pairs, the charged topological defects of the system. We compute the typical energy barrier for these objects to cross incompressible regions within the disordered system using a Hartree-Fock approach, and show how this leads to multiple activation energies when the system is biased. We then demonstrate using a bosonic Chern-Simons theory that in drag geometries, current in a single layer directly leads to forces on only two of the four types of merons, inducing dissipation only in the drive layer. Dissipation in the drag layer results from interactions among the merons, resulting in very different temperature dependences for the drag and drive layers, in qualitative agreement with experiment.Comment: 4 pages, 2 figure

Self-dual vortices in a Maxwell-Chern-Simons model with non-minimal coupling

We find self-dual vortex solutions in a Maxwell-Chern-Simons model with anomalous magnetic moment. From a recently developed N=2-supersymmetric extension, we obtain the proper Bogomol'nyi equations together with a Higgs potential allowing both topological and non-topological phases in the theory.Comment: 12 pages, 9 figures, 2 tables; some typos corrected, one reference updated. To be published in the Int. J. Mod. Phys. A (1999

The first high-amplitude delta Scuti star in an eclipsing binary system

We report the discovery of the first high-amplitude delta Scuti star in an eclipsing binary, which we have designated UNSW-V-500. The system is an Algol-type semi-detached eclipsing binary of maximum brightness V = 12.52 mag. A best-fitting solution to the binary light curve and two radial velocity curves is derived using the Wilson-Devinney code. We identify a late A spectral type primary component of mass 1.49+/-0.02 M_sun and a late K spectral type secondary of mass 0.33+/-0.02 M_sun, with an inclination of 86.5+/-1.0 degrees, and a period of 5.3504751+/-0.0000006 d. A Fourier analysis of the residuals from this solution is performed using PERIOD04 to investigate the delta Scuti pulsations. We detect a single pulsation frequency of f_1 = 13.621+/-0.015 c/d, and it appears this is the first overtone radial mode frequency. This system provides the first opportunity to measure the dynamical mass for a star of this variable type; previously, masses have been derived from stellar evolution and pulsation models.Comment: 7 pages, 6 figures, 2 tables, for submission to MNRAS, v2: paper size change, small typographical changes to abstrac

Reliability Testing of AlGaN/GaN HEMTs Under Multiple Stressors

We performed an experiment on AlGaN/GaN HEMTs with high voltage and high power as stressors. We found that devices tested under high power generally degraded more than those tested under high voltage. In particular, the high-voltage-tested devices did not degrade significantly as suggested by some papers in the literature. The same papers in the literature also suggest that high voltages cause cracks and pits. However, the high-voltage-tested devices in this study do not exhibit cracks or pits in TEM images, while the high-power-tested devices exhibit pits