Energy Management for Hypervisor-Based Virtual Machines

Current approaches to power management are based on operating systems with full knowledge of and full control over the underlying hardware; the distributed nature of multi-layered virtual machine environments renders such approaches insufficient. In this paper, we present a novel framework for energy management in modular, multi-layered operating system structures. The framework provides a unified model to partition and distribute energy, and mechanisms for energy-aware resource accounting and allocation. As a key property, the framework explicitly takes the recursive energy consumption into account, which is spent, e.g., in the virtualization layer or subsequent driver components. Our prototypical implementation targets hypervisor- based virtual machine systems and comprises two components: a host-level subsystem, which controls machine-wide energy constraints and enforces them among all guest OSes and service components, and, complementary, an energy-aware guest operating system, capable of fine-grained applicationspecific energy management. Guest level energy management thereby relies on effective virtualization of physical energy effects provided by the virtual machine monitor. Experiments with CPU and disk devices and an external data acquisition system demonstrate that our framework accurately controls and stipulates the power consumption of individual hardware devices, both for energy-aware and energyunaware guest operating systems

Pyroptosis and gasdermins—Emerging insights and therapeutic opportunities in metabolic dysfunction-associated steatohepatitis

In recent years, there has been a rapid expansion in our understanding of regulated cell death, leading to the discovery of novel mechanisms that govern diverse cell death pathways. One recently discovered type of cell death is pyroptosis, initially identified in the 1990s as a caspase-1-dependent lytic cell death. However, further investigations have redefined pyroptosis as a regulated cell death that relies on the activation of pore-forming proteins, particularly the gasdermin family. Among the key regulators of pyroptosis is the inflammasome sensor NOD-like receptor 3 (NLRP3), a critical innate immune sensor responsible for regulating the activation of caspase-1 and gasdermin D. A deeper understanding of pyroptosis and its interplay with other forms of regulated cell death is emerging, shedding light on a complex regulatory network controlling pore-forming proteins and cell fate. Cell death processes play a central role in diseases such as metabolic dysfunction-associated steatotic liver disease, metabolic dysfunction-associated steatohepatitis, autoinflammatory disorders, and cancer. Cell death often acts as a starting point in these diseases, making it an appealing target for drug development. Yet, the complete molecular mechanisms are not fully understood, and new discoveries reveal promising novel avenues for therapeutic interventions. In this review, we summarize recent evidence on pathways and proteins controlling pyroptosis and gasdermins. Furthermore, we will address the role of pyroptosis and the gasdermin family in metabolic dysfunction-associated steatotic liver disease and steatohepatitis. Additionally, we highlight new potential therapeutic targets for treating metabolic dysfunction-associated steatohepatitis and other inflammatory-associated diseases

Energy management for hypervisorbased virtual machines

Current approaches to power management are based on operating systems with full knowledge of and full control over the underlying hardware; the distributed nature of multi-layered virtual machine environments renders such approaches insufficient. In this paper, we present a novel framework for energy management in modular, multi-layered operating system structures. The framework provides aunifiedmodeltopartitionanddistributeenergy, and mechanisms for energy-aware resource accounting and allocation. As a key property, the framework explicitly takes the recursive energy consumption into account, which is spent, e.g., in the virtualization layer or subsequent driver components. Our prototypical implementation targets hypervisor-based virtual machine systems and comprises two components: a host-level subsystem, which controls machine-wide energy constraints and enforces them among all guest OSes and service components, and, complementary, an energy-aware guest operating system, capable of fine-grained applicationspecific energy management. Guest level energy management thereby relies on effective virtualization of physical energy effects provided by the virtual machine monitor. Experiments with CPU and disk devices and an external data acquisition system demonstrate that our framework accurately controls and stipulates the power consumption of individual hardware devices, both for energy-aware and energyunaware guest operating systems.

Energy-aware Processor Management for Virtual Machines

Over the past years, virtualization technology has regained considerable attention in the design of computer systems. Virtual machines establish a development path for incorporating new functionality (server consolidation, transparent migration, secure computing, etc.) into a system that simultaneously retains compatibility to existing OSes and applications. At the very same time, with the ever increasing power density and dissipation of modern servers, energy management is becoming more and more a key concern in the design of operating systems. Research has proposed several approaches to OSdirected control over a computer’s energy consumption, including user- and service-centric management schemes [1,5]. However, all existing approaches assume full control over and full knowledge of the underlying machin

Pyroptosis and gasdermins-Emerging insights and therapeutic opportunities in metabolic dysfunction-associated steatohepatitis.

In recent years, there has been a rapid expansion in our understanding of regulated cell death, leading to the discovery of novel mechanisms that govern diverse cell death pathways. One recently discovered type of cell death is pyroptosis, initially identified in the 1990s as a caspase-1-dependent lytic cell death. However, further investigations have redefined pyroptosis as a regulated cell death that relies on the activation of pore-forming proteins, particularly the gasdermin family. Among the key regulators of pyroptosis is the inflammasome sensor NOD-like receptor 3 (NLRP3), a critical innate immune sensor responsible for regulating the activation of caspase-1 and gasdermin D. A deeper understanding of pyroptosis and its interplay with other forms of regulated cell death is emerging, shedding light on a complex regulatory network controlling pore-forming proteins and cell fate. Cell death processes play a central role in diseases such as metabolic dysfunction-associated steatotic liver disease, metabolic dysfunction-associated steatohepatitis, autoinflammatory disorders, and cancer. Cell death often acts as a starting point in these diseases, making it an appealing target for drug development. Yet, the complete molecular mechanisms are not fully understood, and new discoveries reveal promising novel avenues for therapeutic interventions. In this review, we summarize recent evidence on pathways and proteins controlling pyroptosis and gasdermins. Furthermore, we will address the role of pyroptosis and the gasdermin family in metabolic dysfunction-associated steatotic liver disease and steatohepatitis. Additionally, we highlight new potential therapeutic targets for treating metabolic dysfunction-associated steatohepatitis and other inflammatory-associated diseases

The Münzkabinett, Staatliche Museen zu Berlin (Preußischer Kulturbesitz), in 2020

Jahresbericht 2020 des Berliner Münzkabinetts.Annual report 2020 of the Berlin Münzkabinett