278 research outputs found
Nuclear weak interaction rates in primordial nucleosynthesis
We calculate the weak interaction rates of selected light nuclei during the
epoch of Big Bang Nucleosynthesis (BBN), and we assess the impact of these
rates on nuclear abundance flow histories and on final light element abundance
yields. We consider electron and electron antineutrino captures on 3He and 7Be,
and the reverse processes of positron capture and electron neutrino capture on
3H and 7Li. We also compute the rates of positron and electron neutrino capture
on 6He. We calculate beta and positron decay transitions where appropriate. As
expected, the final standard BBN abundance yields are little affected by
addition of these weak processes, though there can be slight alterations of
nuclear flow histories. However, non-standard BBN scenarios, e.g., those
involving out of equilibrium particle decay with energetic final state
neutrinos, may be affected by these processes.Comment: 10 pages, 6 figure
Weak Interaction Rate Coulomb Corrections in Big Bang Nucleosynthesis
We have applied a fully relativistic Coulomb wave correction to the weak
reactions in the full Kawano/Wagoner Big Bang Nucleosynthesis (BBN) code. We
have also added the zero temperature radiative correction. We find that using
this higher accuracy Coulomb correction results in good agreement with previous
work, giving only a modest 0.04 percent increase in helium mass fraction over
correction prescriptions applied previously in BBN calculations. We have
calculated the effect of these corrections on other light element abundance
yields in BBN and we have studied these yields as functions of electron
neutrino lepton number. This has allowed insights into the role of the Coulomb
correction in the setting of the neutron-to-proton ratio during the BBN epoch.
We find that the lepton capture processes' contributions to this ratio are only
second order in the Coulomb correction.Comment: 8 pages, 3 figure
Big Bang Nucleosynthesis with Independent Neutrino Distribution Functions
We have performed new Big Bang Nucleosynthesis calculations which employ
arbitrarily-specified, time-dependent neutrino and antineutrino distribution
functions for each of up to four neutrino flavors. We self-consistently couple
these distributions to the thermodynamics, the expansion rate and scale
factor-time/temperature relationship, as well as to all relevant weak,
electromagnetic, and strong nuclear reaction processes in the early universe.
With this approach, we can treat any scenario in which neutrino or antineutrino
spectral distortion might arise. These scenarios might include, for example,
decaying particles, active-sterile neutrino oscillations, and active-active
neutrino oscillations in the presence of significant lepton numbers. Our
calculations allow lepton numbers and sterile neutrinos to be constrained with
observationally-determined primordial helium and deuterium abundances. We have
modified a standard BBN code to perform these calculations and have made it
available to the community.Comment: 9 pages, 5 figure
Coherent Active-Sterile Neutrino Flavor Transformation in the Early Universe
We solve the problem of coherent Mikheyev-Smirnov-Wolfenstein (MSW) resonant
active-to-sterile neutrino flavor conversion driven by an initial lepton number
in the early universe. We find incomplete destruction of lepton number in this
process and a sterile neutrino energy distribution with a distinctive cusp and
high energy tail. These features imply alteration of the non-zero lepton number
primordial nucleosynthesis paradigm when there exist sterile neutrinos with
rest masses ~ 1 eV. This could result in better light element probes of
(constraints on) these particles.Comment: 4 pages, 3 figures, matches version printed in PR
Local GABA concentration is related to network-level resting functional connectivity
Anatomically plausible networks of functionally inter-connected regions have been reliably demonstrated at rest, although the neurochemical basis of these ‘resting state networks’ is not well understood. In this study, we combined magnetic resonance spectroscopy (MRS) and resting state fMRI and demonstrated an inverse relationship between levels of the inhibitory neurotransmitter GABA within the primary motor cortex (M1) and the strength of functional connectivity across the resting motor network. This relationship was both neurochemically and anatomically specific. We then went on to show that anodal transcranial direct current stimulation (tDCS), an intervention previously shown to decrease GABA levels within M1, increased resting motor network connectivity. We therefore suggest that network-level functional connectivity within the motor system is related to the degree of inhibition in M1, a major node within the motor network, a finding in line with converging evidence from both simulation and empirical studies
From crystalline to amorphous calcium pyrophosphates:a solid state Nuclear Magnetic Resonance perspective
Hydrated calcium pyrophosphates (CPP, Ca2P2O7·nH2O) are a fundamental family of materials among osteoarticular pathologic calcifications. In this contribution, a comprehensive multinuclear NMR (Nuclear Magnetic Resonance) study of four crystalline and two amorphous phases of this family is presented. 1H, 31P and 43Ca MAS (Magic Angle Spinning) NMR spectra were recorded, leading to informative fingerprints characterizing each compound. In particular, different 1H and 43Ca solid state NMR signatures were observed for the amorphous phases, depending on the synthetic procedure used. The NMR parameters of the crystalline phases were determined using the GIPAW (Gauge Including Projected Augmented Wave) DFT approach, based on first-principles calculations. In some cases, relaxed structures were found to improve the agreement between experimental and calculated values, demonstrating the importance of proton positions and pyrophosphate local geometry in this particular NMR crystallography approach. Such calculations serve as a basis for the future ab initio modeling of the amorphous CPP phases. Statement of significance The general concept of NMR crystallography is applied to the detailed study of calcium pyrophosphates (CPP), whether hydrated or not, and whether crystalline or amorphous. CPP are a fundamental family of materials among osteoarticular pathologic calcifications. Their prevalence increases with age, impacting on 17.5% of the population after the age of 80. They are frequently involved or associated with acute articular arthritis such as pseudogout. Current treatments are mainly directed at relieving the symptoms of joint inflammation but not at inhibiting CPP formation nor at dissolving these crystals. The combination of advanced NMR techniques, modeling and DFT based calculation of NMR parameters allows new original insights in the detailed structural description of this important class of biomaterials
Historic hydrological droughts 1891–2015: systematic characterisation for a diverse set of catchments across the UK
Hydrological droughts occur in all climate zones and can have severe impacts on society and the environment. Understanding historical drought occurrence and quantifying severity is crucial for underpinning drought risk assessments and developing drought management plans. However, hydrometric records are often short and capture only a limited range of variability. The UK is no exception: numerous severe droughts over the past 50 years have been well captured by observations from a dense hydrometric network. However, a lack of long-term observations means that our understanding of drought events in the early 20th century and late 19th century is limited. Here we take advantage of new reconstructed flow series for 1891 to 2015 to identify and characterise historic hydrological droughts for 108 near-natural catchments across the UK using the standardised streamflow index (SSI). The identified events are ranked according to four event characteristics (duration, accumulated deficit, mean deficit and maximum intensity), and their severity is reviewed in the context of events of the recent past (i.e. the last 50 years). This study represents the first national-scale assessment and ranking of hydrological droughts. Whilst known major drought events were identified, we also shed light on events which were regionally important, such as those in 1921 and 1984 (which were important in the south-east and north-west of the UK, respectively). Events which have been poorly documented, such as those of the 1940s in the post-war years or the early 1970s (prior to the landmark 1975–1976 event), were found to be important in terms of their spatial coverage and severity. This improved knowledge of historic events can support improved long-term water resource planning approaches. Given the universal importance of historical drought appraisal, our systematic approach to historical drought assessment provides a methodology that could be applied in other settings internationally
The 'dirty dozen' of freshwater science: detecting then reconciling hydrological data biases and errors
Sound water policy and management rests on sound hydrometeorological and ecological data. Conversely, unrepresentative, poorly collected, or erroneously archived data introduce uncertainty regarding the magnitude, rate, and direction of environmental change, in addition to undermining confidence in decision-making processes. Unfortunately, data biases and errors can enter the information flow at various stages, starting with site selection, instrumentation, sampling/measurement procedures, postprocessing and ending with archiving systems. Techniques such as visual inspection of raw data, graphical representation, and comparison between sites, outlier, and trend detection, and referral to metadata can all help uncover spurious data. Tell-tale signs of ambiguous and/or anomalous data are highlighted using 12 carefully chosen cases drawn mainly from hydrology (‘the dirty dozen’). These include evidence of changes in site or local conditions (due to land management, river regulation, or urbanization); modifications to instrumentation or inconsistent observer behavior; mismatched or misrepresentative sampling in space and time; treatment of missing values, postprocessing and data storage errors. Also for raising awareness of pitfalls, recommendations are provided for uncovering lapses in data quality after the information has been gathered. It is noted that error detection and attribution are more problematic for very large data sets, where observation networks are automated, or when various information sources have been combined. In these cases, more holistic indicators of data integrity are needed that reflect the overall information life-cycle and application(s) of the hydrological data
A multi-objective ensemble approach to hydrological modelling in the UK: an application to historic drought reconstruction
Hydrological models can provide estimates of streamflow pre- and post-observations, which enable greater understanding of past hydrological behaviour, and potential futures. In this paper, a new multi-objective calibration method was derived and tested for 303 catchments in the UK, and the calibrations were used to reconstruct river flows back to 1891, in order to provide a much longer view of past hydrological variability, given the brevity of most UK river flow records which began post-1960. A Latin hypercube sample of 500 000 parameterisations for the GR4J model for each catchment were evaluated against six evaluation metrics covering all aspects of the flow regime from high, median, and low flows. The results of the top ranking model parameterisation (LHS1), and also the top 500 (LHS500), for each catchment were used to provide a deterministic result whilst also accounting for parameter uncertainty. The calibrations are generally good at capturing observed flows, with some exceptions in heavily groundwater-dominated catchments, and snowmelt and artificially influenced catchments across the country. Reconstructed flows were appraised over 30-year moving windows and were shown to provide good simulations of flow in the early parts of the record, in cases where observations were available. To consider the utility of the reconstructions for drought simulation, flow data for the 1975–1976 drought event were explored in detail in nine case study catchments. The model's performance in reproducing the drought events was found to vary by catchment, as did the level of uncertainty in the LHS500. The Standardised Streamflow Index (SSI) was used to assess the model simulations' ability to simulate extreme events. The peaks and troughs of the SSI time series were well represented despite slight over- or underestimations of past drought event magnitudes, while the accumulated deficits of the drought events extracted from the SSI time series verified that the model simulations were overall very good at simulating drought events. This paper provides three key contributions: (1) a robust multi-objective model calibration framework for calibrating catchment models for use in both general and extreme hydrology; (2) model calibrations for the 303 UK catchments that could be used in further research, and operational applications such as hydrological forecasting; and (3) ∼ 125 years of spatially and temporally consistent reconstructed flow data that will allow comprehensive quantitative assessments of past UK drought events, as well as long-term analyses of hydrological variability that have not been previously possible, thus enabling water resource managers to better plan for extreme events and build more resilient systems for the future
Individual participant data (IPD)-level meta-analysis of randomised controlled trials to estimate the vitamin D dietary requirements in dark-skinned individuals resident at high latitude
Context and purpose There is an urgent need to develop vitamin D dietary recommendations for dark-skinned populations resident at high latitude. Using data from randomised controlled trials (RCTs) with vitamin D3-supplements/fortified foods, we undertook an individual participant data-level meta-regression (IPD) analysis of the response of wintertime serum 25-hydroxyvitamin (25(OH)D) to total vitamin D intake among dark-skinned children and adults residing at ≥ 40° N and derived dietary requirement values for vitamin D. Methods IPD analysis using data from 677 dark-skinned participants (of Black or South Asian descent; ages 5–86 years) in 10 RCTs with vitamin D supplements/fortified foods identified via a systematic review and predefined eligibility criteria. Outcome measures were vitamin D intake estimates across a range of 25(OH)D thresholds. Results To maintain serum 25(OH)D concentrations ≥ 25 and 30 nmol/L in 97.5% of individuals, 23.9 and 27.3 µg/day of vitamin D, respectively, were required among South Asian and 24.1 and 33.2 µg/day, respectively, among Black participants. Overall, our age-stratified intake estimates did not exceed age-specific Tolerable Upper Intake Levels for vitamin D. The vitamin D intake required by dark-skinned individuals to maintain 97.5% of winter 25(OH)D concentrations ≥ 50 nmol/L was 66.8 µg/day. This intake predicted that the upper 2.5% of individuals could potentially achieve serum 25(OH)D concentrations ≥ 158 nmol/L, which has been linked to potential adverse effects in older adults in supplementation studies. Conclusions Our IPD-derived vitamin D intakes required to maintain 97.5% of winter 25(OH)D concentrations ≥ 25, 30 and 50 nmol/L are substantially higher than the equivalent estimates for White individuals. These requirement estimates are also higher than those currently recommended internationally by several agencies, which are based predominantly on data from Whites and derived from standard meta-regression based on aggregate data. Much more work is needed in dark-skinned populations both in the dose–response relationship and risk characterisation for health outcomes.Peer reviewe
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