7 research outputs found
Providing Dignity Therapy at Hospice Witswatersrand and Soweto Hospice's Adult Day Program
Special Studies Experience -- Johannesburg, South Africa -- Summer 2015 -- Partner Agencies: Soweto Hospice; Hospice Witswatersrandhttp://deepblue.lib.umich.edu/bitstream/2027.42/116189/1/Poster_Chowchuvech.pd
The culture difference influence on management when innovation occurs in Ericsson Company : GRADUATION PROEJCT IN INNOVATION MANAGMENT
Effect of Various Microorganisms Found in Cosmetics On the Normal and Injured Eye of the Rabbit
A Review of Compounds Exhibiting Anti-Orthopoxvirus Activity in Animal Models
Several animal models using mice (most frequently), rabbits, or monkeys have been used to identify compounds active against orthopoxvirus infections. The treatment of vaccinia virus infections has been well studied in models involving infection of scarified skin or eyes, or resulting from intravenous, intraperitoneal, intracerebral, or intranasal virus inoculation. Cowpox virus has been used in intranasal or aerosol infection studies to evaluate the treatment of lethal respiratory infections. Rabbitpox, monkeypox, and variola viruses have been employed to a lesser extent than the other viruses in chemotherapy experiments. A review of the literature over the past 50 years has identified a number of compounds effective in treating one or more of these infections, which include thiosemicarbazones, nucleoside and nucleotide analogs, interferon, interferon inducers, and other unrelated compounds. Substances that appear to have the greatest potential as anti-orthopoxvirus agents are the acyclic nucleotides, (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (cidofovir, HPMPC) and 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine (cyclic HPMPC), and the acyclic nucleoside analog, 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine (S2242). Other classes of compounds that have not been sufficiently studied in lethal infection models and deserve further consideration are thiosemicarbazones related to methisazone, and analogs of adenosine-N1-oxide and 1-(benzyloxy)adenosine