35 research outputs found
Regge behaviour of distribution functions and evolution of gluon distribution function in Next-to-Leading order at low-x
Evolution of gluon distribution function from
Dokshitzer-Gribov-Lipatov-Altarelli-Parisi (DGLAP) evolution equation in
next-to-leading order (NLO) at low-x is presented assuming the Regge behaviour
of quarks and gluons at this limit. We compare our results of gluon
distribution function with MRST2004, GRV98LO and GRV98NLO parameterizations and
show the compatibility of Regge behaviour of quark and gluon distribution
functions with perturbative quantum chromodynamics (PQCD) at low-x.Comment: 12 pages, 4 figure
Prediction of anti-Alzheimer’s activity of flavonoids targeting acetylcholinesterase in silico
Introduction – Prenylated and pyrano-flavonoids of the genus Artocarpus J. R. Forster & G. Forster are well known for their acetylcholinesterase (AchE) inhibitory, anticholinergic, antiinflammatory, antimicrobial, antioxidant, antiproliferative and tyrosinase inhibitory activities. Some of these compounds have also been shown to be effective against Alzheimer’s disease. Objective – The aim of the in silico study was to establish protocols to predict the most effective flavonoid from prenylated and pyrano-flavonoid classes for AchE inhibition linking to the potential treatment of Alzheimer’s disease. Methodology – Three flavonoids isolated from Artocarpus anisophyllus Miq. were selected for the study. With these compounds, Lipinski filter, ADME/Tox screening, molecular docking and QSAR were performed in silico. In vitro activity was evaluated by bioactivity staining based on the Ellman’s method. Results – In the Lipinski filter and ADME/Tox screening, all test compounds produced positive results, but in the target fishing, only one flavonoid could successfully target AchE. Molecular docking was performed on this flavonoid, and this compound gained the score as -13.5762. From the QSAR analysis the IC50 was found to be 1659.59 nM. Again, 100 derivatives were generated from the parent compound and docking was performed. The derivative number 20 was the best scorer i.e., -31.6392 and IC50 was predicted as 6.025 nM. Conclusion – Results indicated that flavonoids could be efficient inhibitors of AchE and thus, could be useful in the management of Alzheimer’s disease
Regge behaviour of distribution functions and t and x-evolutions of gluon distribution function at low-x
In this paper t and x-evolutions of gluon distribution function from
Dokshitzer-Gribov-Lipatov-Altarelli-Parisi(DGLAP) evolution equation in leading
order(LO) at low-x, assuming the Regge behaviour of quark and gluon at this
limit, are presented. We compare our results of gluon distribution function
with MRST 2001, MRST 2004 and GRV '98 parameterizations and show the
compatibility of Regge behaviour of quark and gluon distribution functions with
perturbative quantum chromodynamics(PQCD) at low-x. We also discuss the
limitations of Taylor series expansion method used earlier to solve DGLAP
evolution equations, in the Regge behaviour of distribution functions.Comment: 19 pages, 7 figure
Observational Constraints of Modified Chaplygin Gas in Loop Quantum Cosmology
We have considered the FRW universe in loop quantum cosmology (LQC) model
filled with the dark matter (perfect fluid with negligible pressure) and the
modified Chaplygin gas (MCG) type dark energy. We present the Hubble parameter
in terms of the observable parameters , and
with the redshift and the other parameters like , , and .
From Stern data set (12 points), we have obtained the bounds of the arbitrary
parameters by minimizing the test. The best-fit values of the
parameters are obtained by 66%, 90% and 99% confidence levels. Next due to
joint analysis with BAO and CMB observations, we have also obtained the bounds
of the parameters () by fixing some other parameters and .
From the best fit of distance modulus for our theoretical MCG model in
LQC, we concluded that our model is in agreement with the union2 sample data.Comment: 14 pages, 10 figures, Accepted in EPJC. arXiv admin note: text
overlap with arXiv:astro-ph/0311622 by other author
Model Independent Analysis of the Forward-Backward Asymmetry for the Decay
The sensitivity of the zero position of the forward backward asymmetry
for the exclusive
decay is examined by using most general non-standard 4-fermion interactions.
Our analysis shows that the zero position of the forward backward asymmetry is
very sensitive to the sign and size of the Wilson coefficients corresponding to
the new vector type interactions, which are the counter partners of the usual
Standard Model operators but have opposite chirality. In addition to these, the
other significant effect comes from the interference of Scalar-Pseudoscalar and
Tensor type operators. These results will not only enhance our theoretical
understanding about the axial vector mesons but will also serve as a good tool
to look for physics beyond the SM.Comment: 14 pages, 8 figures, Published version that appears in EPJ
Fixed points in interacting dark energy models
The dynamical behaviors of two interacting dark energy models are considered.
In addition to the scaling attractors found in the non-interacting quintessence
model with exponential potential, new accelerated scaling attractors are also
found in the interacting dark energy models. The coincidence problem is reduced
to the choice of parameters in the interacting dark energy models.Comment: v3: 5 figures and 2 tables, add discussions on perturbations and
motivations for the interaction, main results unchanged. PLB in pres
Table 3: Factors associated with anemia among women ageing between 15 and 49 years in Bangladesh, 2011.
An atypical p.N215S variant of Fabry disease with end-stage renal failure
Fabry disease is an X-linked metabolic disorder resulting in widespread deposition of Globotriaosylceramide within a variety of human tissues. The classical Fabry phenotype is one of early onset disease, with extensive tissue involvement resulting in acroparaesthesia, gastrointestinal disturbances, angiokeratoma, cornea verticillata renal failure, and cardiovascular disease.We describe two brothers exhibiting the GLA p.N215S mutation, a variant most often conferring a late-onset disease confined to the myocardium.The proband was diagnosed aged 34, following investigation into proteinuria.Despite Enzyme Replacement Therapy, he progressed to end-stage renal failure, and subsequently received a renal transplant. He also developed hypertrophic cardiomyopathy.His sibling however, whose disease was detected aged 32 following screening, exhibits mild left ventricular hypertrophy, and no evidence of renal disease. He remains clinically asymptomatic.This case report details a discordant phenotype in brothers with Fabry disease and p.N215S mutation. Despite the fact that in the majority of patients this mutation is associated with a late onset presentation with hypertrophic cardiomyopathy, we have clearly demonstrated that patients with GLA p.N215S mutation can present with the classical phenotype. Further studies are required to elucidate the underlying modifying factors that influence clinical presentation with a more severe phenotype. Keywords: Fabry disease, p.N215S, Genetics, Metabolic diseas
Simple tool in a complex case:use of the nailfold capillaroscopy
summary:Let denote the space of infinite matrices for which for all with . We characterize the upper triangular positive matrices from , , by using a special kind of Schur multipliers and the G. Bennett factorization technique. Also some related results are stated and discussed