Governance: Mature Paradigm or Chicken Soup for European Public Management?

Sørensen and Torfing assert that “governance” has become a highly influential paradigm, able to influence the conduct of governing and thus contribute to improving our economies and societies. In responding, we take issue with this pivotal claim, arguing that governance is rather a parochial and decaying paradigm, which failed to improve the way societies and economies were governed

A Random Forest-Cellular Automata modelling approach to explore future land use/cover change in Attica (Greece), under different socio-economic realities and scales

This paper explores potential future land use/cover (LUC) dynamics in the Attica region, Greece, under three distinct economic performance scenarios. During the last decades, Attica underwent a significant and predominantly unregulated process of urban growth, due to a substantial increase in housing demand coupled with limited land use planning controls. However, the recent financial crisis affected urban growth trends considerably. This paper uses the observed LUC trends between 1991 and 2016 to sketch three divergent future scenarios of economic development. The observed LUC trends are then analysed using 27 dynamic, biophysical, socio-economic, terrain and proximity-based factors, to generate transition potential maps, implementing a Random Forests (RF) regression modelling approach. Scenarios are projected to 2040 by implementing a spatially explicit Cellular Automata (CA) model. The resulting maps are subjected to a multiple resolution sensitivity analysis to assess the effect of spatial resolution of the input data to the model outputs. Findings show that, under the current setting of an underdeveloped land use planning apparatus, a long-term scenario of high economic growth will increase built-up surfaces in the region by almost 24%, accompanied by a notable decrease in natural areas and cropland. Interestingly, in the case that the currently negative economic growth rates persist, artificial surfaces in the region are still expected to increase by approximately 7.5% by 2040

Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium .

peer reviewedOBJECTIVE: The endogenous role of the VEGF family member vascular endothelial growth factor-B (VEGF-B) in pathological angiogenesis remains unclear. METHODS AND RESULTS: We studied the role of VEGF-B in various models of pathological angiogenesis using mice lacking VEGF-B (VEGF-B(-/-)) or overexpressing VEGF-B(167). After occlusion of the left coronary artery, VEGF-B deficiency impaired vessel growth in the ischemic myocardium whereas, in wild-type mice, VEGF-B(167) overexpression enhanced revascularization of the infarct and ischemic border zone. By contrast, VEGF-B deficiency did not affect vessel growth in the wounded skin, hypoxic lung, ischemic retina, or ischemic limb. Moreover, VEGF-B(167) overexpression failed to enhance vascular growth in the skin or ischemic limb. CONCLUSIONS: VEGF-B appears to have a relatively restricted angiogenic activity in the ischemic heart. These insights might offer novel therapeutic opportunitie

Debating the urban dimension of territorial cohesion

The Territorial Cohesion goal was only included in the EU Treaty by 2009, with a view to promote a more balanced and harmonious European territory. One year earlier (2008), the European Commission (EC) published the ‘Green Paper on Territorial Cohesion—Turning territorial diversity into strength’. Neither one, nor the other, clearly defines the meaning of the Territorial Cohesion concept. The later, however, proposes three main policy responses towards more balanced and harmonious development: (i) Concentration: overcoming differences in density; (ii) Connecting territories: overcoming distance; and (iii) Cooperation: overcoming division. Although not explicitly, this document identifies several ‘urban questions’ to be dealt when promoting territorial cohesive policies: avoiding diseconomies of very large agglomerations and urban sprawl processes, combating urban decay and social exclusion, avoiding excessive concentrations of growth, promoting access to integrated transport systems and creating metropolitan bodies. In this light, this chapter proposes to debate the importance of the urban dimension to achieve the goal of territorial cohesion at several territorial levels.info:eu-repo/semantics/acceptedVersio

Gene Expression Profiles of the NCI-60 Human Tumor Cell Lines Define Molecular Interaction Networks Governing Cell Migration Processes

Although there is extensive information on gene expression and molecular interactions in various cell types, integrating those data in a functionally coherent manner remains challenging. This study explores the premise that genes whose expression at the mRNA level is correlated over diverse cell lines are likely to function together in a network of molecular interactions. We previously derived expression-correlated gene clusters from the database of the NCI-60 human tumor cell lines and associated each cluster with function categories of the Gene Ontology (GO) database. From a cluster rich in genes associated with GO categories related to cell migration, we extracted 15 genes that were highly cross-correlated; prominent among them were RRAS, AXL, ADAM9, FN14, and integrin-beta1. We then used those 15 genes as bait to identify other correlated genes in the NCI-60 database. A survey of current literature disclosed, not only that many of the expression-correlated genes engaged in molecular interactions related to migration, invasion, and metastasis, but that highly cross-correlated subsets of those genes engaged in specific cell migration processes. We assembled this information in molecular interaction maps (MIMs) that depict networks governing 3 cell migration processes: degradation of extracellular matrix, production of transient focal complexes at the leading edge of the cell, and retraction of the rear part of the cell. Also depicted are interactions controlling the release and effects of calcium ions, which may regulate migration in a spaciotemporal manner in the cell. The MIMs and associated text comprise a detailed and integrated summary of what is currently known or surmised about the role of the expression cross-correlated genes in molecular networks governing those processes

Anti-adhesion and Anti-biofilm Potential of Organosilane Nanoparticles against Foodborne Pathogens

Nowadays, modification of surfaces by nanoparticulate coatings is a simple process that may have applications in reducing the prevalence of bacterial cells both on medical devices and food processing surfaces. To this direction, biofilm biological cycle of Salmonella Typhimurium, Listeria monocytogenes, Escherichia coli O157:H7, Staphylococcus aureus, and Yersinia enterocolitica on stainless steel and glass surfaces, with or without nanocoating was monitored. To achieve this, four different commercial nanoparticle compounds (two for each surface) based on organo-functionalized silanes were selected. In total 10 strains of above species (two for each species) were selected to form biofilms on modified or not, stainless steel or glass surfaces, incubated at 37°C for 72 h. Biofilm population was enumerated by bead vortexing-plate counting method at four time intervals (3, 24, 48, and 72 h). Organosilane based products seemed to affect bacterial attachment on the inert surfaces and/or subsequent biofilm formation, but it was highly dependent on the species and material of surfaces involved. Specifically, reduced bacterial adhesion (at 3 h) of Salmonella and E. coli was observed (P < 0.05) in nanocoating glass surfaces in comparison with the control ones. Moreover, fewer Salmonella and Yersinia biofilm cells were enumerated on stainless steel coupons coated with organosilanes, than on non-coated surfaces at 24 h (P < 0.05). This study gives an insight to the efficacy of organosilanes based coatings against biofilm formation of foodborne pathogens, however, further studies are needed to better understand the impact of surface modification and the underlying mechanisms which are involved in this phenomenon

Effect of Satureja thymbra Essential Oil on Growth-No Growth Interfaces of Listeria monocytogenes Scott A and Salmonella Enteritidis PT4, at Various Temperatures, pH, and Water Activities

Antimicrobial efficacy of Satureja thymbra essential oil against Listeria monocyto genes Scott A and Salmonella ser. Enteritidis PT4 was evaluated in vitro by modeling the growth boundaries at various temperatures, pH, and NaCl concentrations. Growth no growth (turbidity) data were modeled by logistic polynomial regression. The concordance indices and the Hosmer- Lemeshow statistics of both logistic models indicated a good fit to the observed data. Salmonella Enteritidis was more sensitive at increasing salt content as compared with L. monocytogenes. On the other hand, pH changes had greater effect on growth initiation of L. monocytogenes than they had on growth initiation of Salmonella Enteritidis. Presence of essential oil up to 0.06% (vol/vol) had no or little effect on growth initiation of both microorganisms tested, while the concentration of 0.1% (vol/vol) essential oil exhibited great inhibition on growth initiation, especially when it was combined with increased salt content and low temperatures. The antimicrobial potency of S. thymbra essential oil was more pronounced when multiple hurdles were applied. Modeling the growth boundaries offers a useful tool to food microbiologists for assessing the antimicrobial activity in a range of food preservation conditions as compared with the conventional MIC determination

Collaborative governance under austerity in Athens: Interviews and focus groups transcripts with key policy makers, NGOs and informal social networks 2015-2017

Transcripts of 42 interviews and one focus group conducted in Athens (2015-2017) with councilors and local authority officials in an attempt to explore the City’s stance towards austerity and collaboration. Interview codes are provided in a separate sheet. In the second folder a summary of the key points of each interview is provided. The respective file names correspond to the original interview transcript, facilitating access to both documents. Austerity governance, defined as a sustained agenda for reducing public spending, poses new challenges for the organisation of relationships between government, business and citizens in many parts of the world. This project compares how these challenges are addressed in eight countries: Australia, Canada, France, Greece, Ireland, Spain, the UK and the USA. Governments have long sought effective ways of engaging citizen activists and business leaders in decision making, through many formal and informal mechanisms - what we term collaborative governance. The focus of our research is how collaboration contributes to the governance of austerity. Governments and public service leaders argue that collaboration with businesses, voluntary organisations and active citizens is essential for addressing the many challenges posed by austerity. The challenges include transforming public services to cope with cuts, changing citizen expectations and managing demand for services and enhancing the legitimacy of difficult policy decisions by involving people outside government in making them. But at the same time, collaboration can be exclusionary. For example, if there are high levels of protest, governmental and business elites may collaborate in ways that marginalise ordinary citizens to push through unpopular policies. Our challenge is to explore different ways in which collaboration works or fails in governing austerity and whether it is becoming more or less important in doing so. We propose to compare the role of collaboration in governing austerity in eight cities of the aforementioned countries: Athens, Baltimore, Barcelona, Dublin, Leicester, Melbourne, Montreal and Nantes. It is in towns and cities that government has the most immediate and closest day-to-day engagement with citizens and it is for this reason that we chose to locate our research at the urban scale. Our primary objective is to understand whether, and if so how, collaboration among public officials, citizens, business leaders and other actors contributes to austerity governance. For example is there more collaboration, less or are we seeing different kinds of collaboration emerging? Who, if anyone, refuses to collaborate and with what implications for governing austerity? Might collaboration be a way to subvert or resist aspects of austerity? The research is comparative, meaning that it is looking for patterns and to see what lessons and insights countries in different parts of the world might draw from one another. Finding ways to collaborate with citizens has always been important for central and local governments, although collaboration has been a higher political priority in the past 20 years than before. Our study will tell politicians and public officials much about how collaboration works as a way of governing austerity. However we are not trying to 'sell' collaboration, or suggest that those suffering from cuts and wanting to resist them should collaborate if they do not wish to. For citizen activists our research will highlight different strategies and options for speaking truth to power - by engaging with city government and local business elites, or refusing to do so and perhaps focusing on protest instead. We will discover when collaboration serves the ends of community groups and when it does not. Participants in our study, and others, will have the opportunity to discuss these issues at a series of local events, at which we will discuss our findings. The research will also engage with important academic debates about the changing nature of governance. In gathering and comparing a large body of data we will learn about the changing role of government under austerity and whether governing is becoming more elite-focused, remote and hierarchical, or perhaps even more inclusive despite the challenging times in which we live.</p