Noninvasive Embedding of Single Co Atoms in Ge(111)2x1 Surfaces

We report on a combined scanning tunneling microscopy (STM) and density functional theory (DFT) based investigation of Co atoms on Ge(111)2x1 surfaces. When deposited on cold surfaces, individual Co atoms have a limited diffusivity on the atomically flat areas and apparently reside on top of the upper pi-bonded chain rows exclusively. Voltage-dependent STM imaging reveals a highly anisotropic electronic perturbation of the Ge surface surrounding these Co atoms and pronounced one-dimensional confinement along the pi-bonded chains. DFT calculations reveal that the individual Co atoms are in fact embedded in the Ge surface, where they occupy a quasi-stationary position within the big 7-member Ge ring in between the 3rd and 4th atomic Ge layer. The energy needed for the Co atoms to overcome the potential barrier for penetration in the Ge surface is provided by the kinetic energy resulting from the deposition process. DFT calculations further demonstrate that the embedded Co atoms form four covalent Co-Ge bonds, resulting in a Co4+ valence state and a 3d5 electronic configuration. Calculated STM images are in perfect agreement with the experimental atomic resolution STM images for the broad range of applied tunneling voltages.Comment: 19 pages, 15 figures, 3 table

P09-15. Selection of higher avidity HLA-restricted T cell responses as a viral adaptation strategy

Loss of immune reactivity due to HIV mutational escape is well described. Data generated from a large population-based study (n>800) suggested that certain CD8 T cell epitopes are created as a result of HIV adaptation and are associated with enhanced viral replication. Here we sought to investigate the HLA-restricted T-cell responses associated with seven such adaptations

A Trapeze Act: Balancing Unpaid Care Work and Paid Work by Women in Nepal

This working paper seeks to examine the relationship between unpaid care work and paid work that women in low-income households in Nepal perform, and whether, and if so how, they are able to maintain a balance between the two. It also examines the causes and consequences of the double burden on the physical and emotional wellbeing of women and their children. Further, the paper aims to create knowledge about how different stakeholders such as family, community, employers and state can contribute to women’s economic empowerment such that their economic empowerment is optimised (women’s entry into paid work is enabled without deepening their time poverty or worrying about the quality of care received by their family), shared (across generations, so that other women/girls in the family are not left to bear the burden of care) and sustained (such that the quality of care provided to children improves as a result of their mother’s paid work). By examining women’s participation in two economic empowerment programmes – the Enterprise Development Programme (EDP) in Surkhet district and Karnali Employment Programme (KEP) in Jumla district – it also provides policy inputs on how women’s economic empowerment (WEE) policy and programming can generate a ‘double boon’: paid work that empowers women and provides more support for their unpaid care work.UK Department for International DevelopmentInternational Development Research Centre (IDRC)Hewlett Foundatio

From social machines to social protocols:Software engineering foundations for sociotechnical systems

The overarching vision of social machines is to facilitate social processes by having computers provide administrative support. We conceive of a social machine as a sociotechnical system (STS): a software-supported system in which autonomous principals such as humans and organizations interact to exchange information and services. Existing approaches for social machines emphasize the technical aspects and inadequately support the meanings of social processes, leaving them informally realized in human interactions. We posit that a fundamental rethinking is needed to incorporate accountability, essential for addressing the openness of the Web and the autonomy of its principals. We introduce Interaction-Oriented Software Engineering (IOSE) as a paradigm expressly suited to capturing the social basis of STSs. Motivated by promoting openness and autonomy, IOSE focuses not on implementation but on social protocols, specifying how social relationships, characterizing the accountability of the concerned parties, progress as they interact. Motivated by providing computational support, IOSE adopts the accountability representation to capture the meaning of a social machine’s states and transitions. We demonstrate IOSE via examples drawn from healthcare. We reinterpret the classical software engineering (SE) principles for the STS setting and show how IOSE is better suited than traditional software engineering for supporting social processes. The contribution of this paper is a new paradigm for STSs, evaluated via conceptual analysis

Decrement Operators in Belief Change

While research on iterated revision is predominant in the field of iterated belief change, the class of iterated contraction operators received more attention in recent years. In this article, we examine a non-prioritized generalisation of iterated contraction. In particular, the class of weak decrement operators is introduced, which are operators that by multiple steps achieve the same as a contraction. Inspired by Darwiche and Pearl's work on iterated revision the subclass of decrement operators is defined. For both, decrement and weak decrement operators, postulates are presented and for each of them a representation theorem in the framework of total preorders is given. Furthermore, we present two sub-types of decrement operators

Stability of antiphase line defects in nanometer-sized boron-nitride cones

We investigate the stability of boron nitride conical sheets of nanometer size, using first-principles calculations. Our results indicate that cones with an antiphase boundary (a line defect that contains either B-B or N-N bonds) can be more stable than those without one. We also find that doping the antiphase boundaries with carbon can enhance their stability, leading also to the appearance of localized states in the bandgap. Among the structures we considered, the one with the smallest formation energy is a cone with a carbon-modified antiphase boundary that presents a spin splitting of about 0.5 eV at the Fermi level.Comment: 5 two-column pages with 2 figures Accepted for publication in Physical Review B (vol 70, 15 Nov.

The impact of freight transport capacity limitations on supply chain dynamics

We investigate how capacity limitations in the transportation system affect the dynamic behaviour of supply chains. We are interested in the more recently defined, 'backlash' effect. Using a system dynamics simulation approach, we replicate the well-known Beer Game supply chain for different transport capacity management scenarios. The results indicate that transport capacity limitations negatively impact on inventory and backlog costs, although there is a positive impact on the 'backlash' effect. We show that it is possible for both backlog and inventory to simultaneous occur, a situation which does not arise with the uncapacitated scenario. A vertical collaborative approach to transport provision is able to overcome such a trade-off. © 2013 Taylor & Francis

Resynthesized Brassica juncea lines with novel organellar genome constitution obtained through protoplast fusion

This article does not have an abstract

Drug utilization study in diabetic patients seeking medical treatment in a north Indian rural medical college hospital

Background: Diabetes Mellitus is a chronic disease and its life-long management causes burden on lifestyle and financial condition of the patients. Drug utilization studies provide useful insights into the current prescribing practices.Methods: To evaluate the drug utilization pattern of anti-diabetic drugs in diabetic patients. A prospective observational study was carried out in adult diabetic patients visiting the Wards and Outpatient Department of General Medicine of a tertiary care hospital. The demographic data and utilization of different classes of anti-diabetic agents as well as individual drugs were analyzed.Results: In 125 patients (Male-65, Female-60), a total of 379 drugs (average 3.032±2.05) were used per day, out of which 76 (20.05%) were rational fixed dose combinations (FDCs) and 261 (68.86%) were prescribed from National List of Essential Medicines (NLEM) 2015. The number of drugs prescribed to be ingested was 326 (86.01%) and 63 (16.62%) were injectables.Conclusions: It was found that the prescription tendencies of the doctors were quite rational. More improvement can be done by sensitizing them to prescribe more drugs from NLEM. The limitations in the affordability of rural population should be taken care of while prescribing drugs for this chronic disease