The dynamical state of RXCJ1230.7+3439: a multi-substructured merging galaxy cluster

We analyse the kinematical and dynamical state of the galaxy cluster RXCJ1230.7+3439, at z=0.332, using 93 new spectroscopic redshifts of galaxies acquired at the 3.6m TNG telescope and from SDSS DR16 public data. We find that RXCJ1230 appears as a clearly isolated peak in the redshift space, with a global line-of-sight velocity dispersion of $1004_{-122}^{+147}$ km s$^{-1}$, and showing a very complex structure with the presence of three subclusters. Our analyses confirm that the three substructures detected are in a pre-merger phase, where the main interaction takes place with the south-west subclump. We compute a velocity dispersion of $\sigma_\textrm{v} \sim 1000$ and $\sigma_\textrm{v} \sim 800$ km s$^{-1}$ for the main cluster and the south-west substructure, respectively. The central main body and south-west substructure differ by $\sim 870$ km s$^{-1}$ in the LOS velocity. From these data, we estimate a dynamical mass of $M_{200}= 9.0 \pm 1.5 \times 10^{14}$ M$_{\odot}$ and $4.4 \pm 3.3 \times 10^{14}$ M$_{\odot}$ for the RXCJ1230 main body and south-west clump, respectively, which reveals that the cluster will suffer a merging characterized by a 2:1 mass ratio impact. We solve a two-body problem for this interaction and find that the most likely solution suggests that the merging axis lies almost contained in the plane of the sky and the subcluster will fully interact in $\sim0.3$ Gyr. The comparison between the dynamical masses and those derived from X-ray data reveals a good agreement within errors (differences $\sim 15$\%), which suggests that the innermost regions ($<r_{500}$) of the galaxy clumps are almost in hydrostatical equilibrium. To summarize, RXCJ1230 is a young but also massive cluster in a pre-merging phase accreeting other galaxy systems from its environment.Comment: To be published in A&

RXCJ1111.6+4050 galaxy cluster: the observational evidence of a transitional fossil group

We present a detailed kinematical and dynamical study of the galaxy cluster RXCJ1111.6+4050 (RXCJ1111), at z = 0.0756 using 104 new spectroscopic redshifts of galaxies observed at the TNG 3.5m telescope and SDSS DR16 public archive. Our analysis is performed in a multiwavelength context in order to study and compare mainly optical and X-ray properties using XMM-Newton data. We find that RXCJ1111 is a galaxy cluster showing a velocity distribution with clear deviations from Gaussianity, that we are able to explain by the presence of a substructure within the cluster. The two cluster components show velocity dispersions of $644 \pm 56$ km/s and $410 \pm 123$ km/s, which yield dynamical masses of M$_{200}$=$1.9 \pm 0.4 \times10^{14}$ M$_{\odot}$ and $0.6 \pm 0.4 \times 10^{14}$ M$_{\odot}$ for the main system and substructure, respectively. RXCJ1111 presents an elongation in the North-South direction and a gradient of 250-350 km/s/Mpc in the velocity field, suggest that the merger axis between the main system and substructure is slightly tilted with respect to the line-of-sight. The substructure is characterized by a magnitude gap $\Delta m_{12} \ge 1.8$, so it fits the "fossil-like" definition of a galaxy group. Mass estimates derived from X-ray and optical are in good agreement when two galaxy components are considered separately. We propose a 3D merging model and find that the fossil group is in an early phase of collision with the RXCJ1111 main cluster and almost aligned with the line-of-sight. This merging model would explain the slight increase found in the T$_X$ with respect to what we would expect for relaxed clusters. Due to the presence of several brightest galaxies, after this collision, the substructure would presumably lose its fossil condition. Therefore, RXCJ1111 represents the observational evidence that the fossil stage of a system can be temporary and transitional.Comment: 16 pages, 11 figures, 3 tables and 1 appendi

Lensed CMB power spectra from all-sky correlation functions

Weak lensing of the CMB changes the unlensed temperature anisotropy and polarization power spectra. Accounting for the lensing effect will be crucial to obtain accurate parameter constraints from sensitive CMB observations. Methods for computing the lensed power spectra using a low-order perturbative expansion are not good enough for percent-level accuracy. Non-perturbative flat-sky methods are more accurate, but curvature effects change the spectra at the 0.3-1% level. We describe a new, accurate and fast, full-sky correlation-function method for computing the lensing effect on CMB power spectra to better than 0.1% at l<2500 (within the approximation that the lensing potential is linear and Gaussian). We also discuss the effect of non-linear evolution of the gravitational potential on the lensed power spectra. Our fast numerical code is publicly available.Comment: 16 pages, 4 figures. Changes to match PRD version including new section on non-linear corrections. CAMB code available at http://camb.info

Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments

Mathematical models of ion channels, which constitute indispensable components of action potential models, are commonly constructed by fitting to whole-cell patch-clamp data. In a previous study, we fitted cell-specific models to hERG1a (Kv11.1) recordings simultaneously measured using an automated high-throughput system, and studied cell-cell variability by inspecting the resulting model parameters. However, the origin of the observed variability was not identified. Here, we study the source of variability by constructing a model that describes not just ion current dynamics, but the entire voltage-clamp experiment. The experimental artefact components of the model include: series resistance, membrane and pipette capacitance, voltage offsets, imperfect compensations made by the amplifier for these phenomena, and leak current. In this model, variability in the observations can be explained by either cell properties, measurement artefacts, or both. Remarkably, by assuming that variability arises exclusively from measurement artefacts, it is possible to explain a larger amount of the observed variability than when assuming cell-specific ion current kinetics. This assumption also leads to a smaller number of model parameters. This result suggests that most of the observed variability in patch-clamp data measured under the same conditions is caused by experimental artefacts, and hence can be compensated for in post-processing by using our model for the patch-clamp experiment. This study has implications for the question of the extent to which cell-cell variability in ion channel kinetics exists, and opens up routes for better correction of artefacts in patch-clamp data. This article is part of the theme issue 'Uncertainty quantification in cardiac and cardiovascular modelling and simulation'

Development of ultra-light pixelated ladders for an ILC vertex detector

The development of ultra-light pixelated ladders is motivated by the requirements of the ILD vertex detector at ILC. This paper summarizes three projects related to system integration. The PLUME project tackles the issue of assembling double-sided ladders. The SERWIETE project deals with a more innovative concept and consists in making single-sided unsupported ladders embedded in an extra thin plastic enveloppe. AIDA, the last project, aims at building a framework reproducing the experimental running conditions where sets of ladders could be tested

A Comparison of Algorithms for the Construction of SZ Cluster Catalogues

We evaluate the construction methodology of an all-sky catalogue of galaxy clusters detected through the Sunyaev-Zel'dovich (SZ) effect. We perform an extensive comparison of twelve algorithms applied to the same detailed simulations of the millimeter and submillimeter sky based on a Planck-like case. We present the results of this "SZ Challenge" in terms of catalogue completeness, purity, astrometric and photometric reconstruction. Our results provide a comparison of a representative sample of SZ detection algorithms and highlight important issues in their application. In our study case, we show that the exact expected number of clusters remains uncertain (about a thousand cluster candidates at |b|> 20 deg with 90% purity) and that it depends on the SZ model and on the detailed sky simulations, and on algorithmic implementation of the detection methods. We also estimate the astrometric precision of the cluster candidates which is found of the order of ~2 arcmins on average, and the photometric uncertainty of order ~30%, depending on flux.Comment: Accepted for publication in A&A: 14 pages, 7 figures. Detailed figures added in Appendi

A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer [version 1; peer review: 2 approved with reservations]

Automated patch-clamp platforms are widely used and vital tools in both academia and industry to enable high-throughput studies such as drug screening. A leak current to ground occurs whenever the seal between a pipette and cell (or internal solution and cell in high-throughput machines) is not perfectly insulated from the bath (extracellular) solution. Over 1 GΩ seal resistance between pipette and bath solutions is commonly used as a quality standard for manual patch work. With automated platforms it can be difficult to obtain such a high seal resistance between the intra- and extra-cellular solutions. One suggested method to alleviate this problem is using an F− containing internal solution together with a Ca2+ containing external solution — so that a CaF2 crystal forms when the two solutions meet which ‘plugs the holes’ to enhance the seal resistance. However, we observed an unexpected nonlinear-in-voltage and time-dependent current using these solutions on an automated patch-clamp platform. We performed manual patch-clamp experiments with the automated patch-clamp solutions, but no biological cell, and observed the same nonlinear time-dependent leak current. The current could be completely removed by washing out F− ions to leave a conventional leak current that was linear and not time-dependent. We therefore conclude fluoride ions interacting with the CaF2 crystal are the origin of the nonlinear time-dependent leak current. The consequences of such a nonlinear and time-dependent leak current polluting measurements should be considered carefully if it cannot be isolated and subtracted

The OPERA experiment Target Tracker

The main task of the Target Tracker detector of the long baseline neutrino oscillation OPERA experiment is to locate in which of the target elementary constituents, the lead/emulsion bricks, the neutrino interactions have occurred and also to give calorimetric information about each event. The technology used consists in walls of two planes of plastic scintillator strips, one per transverse direction. Wavelength shifting fibres collect the light signal emitted by the scintillator strips and guide it to both ends where it is read by multi-anode photomultiplier tubes. All the elements used in the construction of this detector and its main characteristics are described.Comment: 25 pages, submitted to Nuclear Instrument and Method

Rhythmic dynamics and synchronization via dimensionality reduction : application to human gait

Reliable characterization of locomotor dynamics of human walking is vital to understanding the neuromuscular control of human locomotion and disease diagnosis. However, the inherent oscillation and ubiquity of noise in such non-strictly periodic signals pose great challenges to current methodologies. To this end, we exploit the state-of-the-art technology in pattern recognition and, specifically, dimensionality reduction techniques, and propose to reconstruct and characterize the dynamics accurately on the cycle scale of the signal. This is achieved by deriving a low-dimensional representation of the cycles through global optimization, which effectively preserves the topology of the cycles that are embedded in a high-dimensional Euclidian space. Our approach demonstrates a clear advantage in capturing the intrinsic dynamics and probing the subtle synchronization patterns from uni/bivariate oscillatory signals over traditional methods. Application to human gait data for healthy subjects and diabetics reveals a significant difference in the dynamics of ankle movements and ankle-knee coordination, but not in knee movements. These results indicate that the impaired sensory feedback from the feet due to diabetes does not influence the knee movement in general, and that normal human walking is not critically dependent on the feedback from the peripheral nervous system