The Runaway Sign:: Semiotic Adaptation in Literary Analysis

This article derives a notion of adaptation as a semiotic process from the work of Jesper Hoffmeyer and the Copenhagen-Tartu school of biosemiotics, suggesting it as way of considering fictional writing on genetics and evolution both empirically and analogically. Along these lines, I read changes in significations of reproduction and inheritance in Doris Lessing’s The Marriages Between Zones Three, Four and Five (1980)

Chapter 19 Max Ritvo’s Precision Poetry

This essay reads Max Ritvo’s poetry through a chronology of precision biomedicine: imaging, diagnosis, and treatment. Ritvo’s construction of a patient-consumer avatar in his poetry reflects his position at a biomedical frontier, while poetic form becomes a way of retrieving bodies from a logic of substitution and surrogacy

Narrative in the Age of the Genome

Charts the impact of genetic science on literature, culture and our understanding of what it means to be human

Colston falling

On June 7th, 2020, the statue of Edward Colston in Bristol City Centre was pulled down by an anonymous group of Black Lives Matter protestors following a global uprising against police brutality in the wake of George Floyd's murder by Minneapolis police officer Derek Chauvin. This article combines a first-person account of the build-up to the statue falling and its aftermath with reflections on some of the broader debates, historical and current, around public monuments, state violence, and collective life

Narrative in the Age of the Genome

Shortlisted for the 2021 BSLS Book Prize Genomic technologies have had a profound impact on understandings of what it means to be human and our links to the world we inhabit, and on practices of inhabiting the world. This open access book considers this impact across a range of literary forms, cultural practices, and political imaginaries, and argues that new descriptions of biological value introduced through practices of genomic sequencing from the late 1970s registered a broader crisis of narrative form. Examining a wide range of texts by Doris Lessing, Samuel Delany, Boris and Arkady Strugatsky, Kir Bulychev, Kazuo Ishiguro, Saidiya Hartman, Yaa Gyasi, Svetlana Alexievich, and Jeff VanderMeer, Narrative in the Age of the Genome casts new light on the intersections of genomics with politics of racism, sexuality, labour and gender, neoliberal economics and environmental crisis. The eBook editions of this book are available open access under a CC BY-NC-ND 4.0 licence on bloomsburycollections.com. Open access was funded by The Wellcome Trus

Implementation of the INTERGROWTH-21st Project in Kenya

The African site in the INTERGROWTH-21(st) Project was Parklands, a wealthy suburb of Nairobi, Kenya, with a largely middle-to-high socio-economic status population. There are three hospitals with obstetric units in Parklands, with approximately 4300 births per year. The Newborn Cross-Sectional Study (NCSS) sample was drawn from all three hospitals, covering 100% of births in this target population. The Fetal Growth Longitudinal Study (FGLS) sample was recruited from antenatal clinics serving these hospitals, using the eligibility criteria in the INTERGROWTH-21(st) protocol. Special activities to raise awareness of the study included securing media coverage and distributing leaflets in antenatal clinic waiting rooms. FGLS required women to be recruited in the first trimester; therefore, a major challenge at this study site was the high background frequency of first antenatal consultations in the second trimester. The problem was overcome by the study awareness campaign, as a result of which more women started attending antenatal care earlier in pregnancy

Routine use of cell salvage during cesarean section : a practice evaluation

Introduction: Intraoperative cell salvage is a well‐documented alternative to donor blood transfusion given the scarcity of donor blood pools and the incumbent risk of allogenic blood transfusion. Its use in obstetrics has been limited by concern over fetal alloimmunization due to the risk of fetomaternal hemorrhage. However, there are a paucity of studies reporting on outcome. The aim of this study was to report on a four‐year experience of routine use of intraoperative cell salvage and the impact on subsequent pregnancy outcomes. Material and methods: This was a tertiary center retrospective service evaluation cohort study and included all women undergoing cesarean section between December 2014 and November 2018 in a tertiary obstetric unit, identifying women who had reinfusion of intraoperative cell salvage. Data regarding index pregnancy as well as subsequent pregnancies at the hospital were extracted from hospital electronic records. Subsequent pregnancy outcome and maternal antibody status in that pregnancy were collected up until November 2022. Results: During the study period, 6656 cesarean sections were performed, with 436 (6.6%) receiving reinfusion of salvaged blood. The mean volume of reinfused blood was 396 mL. A total of 49 (0.7%) women received donor blood transfusion. Of those who received reinfusion of salvaged blood, 79 (18.1%) women had subsequent pregnancies over the eight‐year follow‐up period. There was one case (0.23%) of fetal cell alloimmunization demonstrated by the presence of anti‐D antibodies on the subsequent pregnancy booking bloods. Conclusions: Routine intraoperative cell salvage may be used to reduce the need for blood transfusion during cesarean section. The risk of fetal cell alloimmunization in a future pregnancy following reinfusion of intraoperative cell salvage is one in 436. Given an apparent small risk of fetal cell alloimmunization, further work is required to establish the safety profile of intraoperative cell salvage in pregnancy

Quantifying the Impact of Dysmenorrhea Symptoms on Quality-of-Life and Access to Oral Contraceptives by Income

# Background Dysmenorrhea, or painful menstrual periods, is one of the most common gynecological complaints. Most reports of uterine contractions range between moderate to severe pain, and patients often elect to cope with their discomfort without assistance from a physician. In the process, women experiencing dysmenorrhea are more likely to report absenteeism from work and school. # Objectives This study measures the reported impact of dysmenorrhea on patients' lives and elucidates a relationship between income and access to oral contraceptives. # Methods Two hundred women completed a survey about their symptoms, level of pain, treatments, and the extent to which dysmenorrhea affected day-to-day obligations. Most questions were multiple-choice while others permitted several answer selections or were free response. The data was analyzed using JMP statistical software. # Results Eighty-four percent of respondents reported moderate to severe pain during menstruation. This discomfort has caused 65.5% of the cohort to miss work and 68% to avoid participating in social gatherings. Pain relief medications are most often used as treatment - 143 respondents took ibuprofen, 93 took acetaminophen, and 51 took naproxen. 29.5% of respondents are prescribed birth control for cramps and blood flow. Income (p = 0.049), age (p = 0.002), and education (p = 0.002) were significant predictors for oral contraceptive pill (OCP) use. The lowest income groups were found to use OCPs at less than half the rate as the highest income respondents. # Conclusion Dysmenorrhea affected most participants in the cohort with an impact that extends beyond professional obligations. Income was found to be positively correlated with increased OCP use, whereas education level was inversely correlated. Clinicians should consider how patients' backgrounds influence their access to OCP options. An improvement on this study's findings would be to establish a causal relationship between these demographic factors and access to OCPs

Surgical trial in traumatic intracerebral haemorrhage (STITCH) : A randomised controlled trial of early surgery compared with Initial conservative treatment

Funding This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme.Peer reviewedPublisher PD

INTERCOMPARISON OF DIFFERENT RAINFALL PRODUCTS AND VALIDATION OF WRF MODELLED RAINFALL ESTIMATION IN N-W HIMALAYA DURING MONSOON PERIOD

Extreme precipitation events are responsible for major floods in any part of the world. In recent years, simulations and projection of weather conditions to future, with Numerical Weather Prediction (NWP) models like Weather Research and Forecast (WRF), has become an imperative component of research in the field of atmospheric science and hydrology. The validation of modelled forecast is thus have become matter of paramount importance in case of forecasting. This study delivers an all-inclusive assessment of 5 high spatial resolution gridded precipitation products including satellite data products and also climate reanalysis product as compared to WRF precipitation product. The study was performed in river basins of North Western Himalaya (NWH) in India. Performance of WRF model is evaluated by comparing with observational gridded (0.25° × 0.25°) precipitation data from Indian Meteorological Department (IMD). Other products include TRMM Multi Satellite Precipitation Analysis (TMPA) 3B42-v7 product (0.25° × 0.25°) and Global Precipitation Measurement (GPM) product (0.1° × 0.1°). Moreover, climate reanalysis rainfall product from ERA Interim is also used. Bias, Mean Absolute Error, Root Mean Square Error, False Alarm Ratio (FAR), Probability of False Detection (POFD), and Probability of Detection (POD) were calculated with particular rainfall thresholds. TRMM and GPM products were found to be sufficiently close to the observations. All products showed better performance in the low altitude areas i.e. in planes of Upper Ganga and Yamuna basin and Indus basin, and increase in error as topographical variation increases. This study can be used for identifying suitability of WRF forecast data and assessing performance of other rainfall datasets as well