Spitzer Mid-Infrared Spectroscopy of Infrared Luminous Galaxies at z~2 II: Diagnostics

We present mid-IR spectral decomposition of a sample of 48 Spitzer-selected ULIRGs spanning z~1-3 and likely L_IR~10^12-10^13Lsun. Our study aims at quantifying the star-formation and AGN processes in these sources which recent results suggest have evolved strongly between the observed epoch and today. To do this, we study the mid-IR contribution of PAH emission, continuum, and extinction. About 3/4 of our sample are continuum- (i.e. AGN) dominated sources, but ~60% of these show PAH emission, suggesting the presence of star-formation activity. These sources have redder mid-IR colors than typical optically-selected quasars. About 25% of our sample have strong PAH emission, but none are likely to be pure starbursts as reflected in their relatively high 5um hot dust continua. However, their steep 30um-to-14um slopes suggest that star-formation might dominate the total infrared luminosity. Six of our z~2 sources have EW6.2>~0.3um and L_14um>~10^12Lsun (implying L_IR>~10^13Lsun). At these luminosities, such high EW6.2 ULIRGs do not exist in the local Universe. We find a median optical depth at 9.7um of =1.4. This is consistent with local IRAS-selected ULIRGs, but differs from early results on SCUBA-selected z~2 ULIRGs. Similar to local ULIRGs about 25% of our sample show extreme obscuration (tau_9.7>~3) suggesting buried nuclei. In general, we find that our sources are similar to local ULIRGs, but are an order of magnitude more luminous. It is not clear whether our z~2 ULIRGs are simply scaled-up versions of local ULIRGs, or subject to fundamentally different physical processes.Comment: 60 pages, 15 figures, accepted for publication in Ap

Interpreting the Morphology of Diffuse Light Around Satellite Galaxies

Recent observations of surface brightness distributions of both Milky Way and M31 satellite galaxies have revealed many instances of sudden changes or breaks in the slope of the surface brightness profiles (at some break radius, r_break). These breaks are often accompanied by increasingly elliptical isophotes and sometimes by isophote twisting. We investigate the hypothesis of a tidal origin for these features by applying the same ellipse fitting techniques that are used on observed galaxies to numerical simulations of the destruction of satellites, represented by spherical, single-component systems. We examine how observed quantities such as r_break, ellipticity and position angle of the fitted ellipses and amplitude of extra-break population vary with the satellite's orbital eccentricity and phase, and our viewpoint relative to the orbit. We also look at orbit and viewpoint dependence of the rate of change of the latter three quantities with radius. We find that there are trends with orbital phase and eccentricity in all observed quantities, many of which are preserved through a wide variety of viewing angles. In particular, a generic feature of all simulations is a depletion zone just interior to an excess zone, regions in which the surface brightness is lower and higher, respectively, than the initial profile. A clear interpretation of any individual image, however, is likely to be hampered by the dependence of the observable features on these multiple parameters. For example, breaks can be excited by several physical processes and can occur well within the bound satellite population. Nevertheless, we do find we can place loose constraints on the tidal radius, mass loss rate, orbital type and phase of the satellite, and nature of breaks using photometric data alone.Comment: 41 pages, including 17 figures; accepted for publication in AJ; minor changes made to the text, Figure 1 adde

Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice

<p>Abstract</p> <p>Background</p> <p>Familial Alzheimer's disease-linked variants of presenilin (PSEN1 and PSEN2) contribute to the pathophysiology of disease by both gain-of-function and loss-of-function mechanisms. Deletions of <it>PSEN1 </it>and <it>PSEN2 </it>in the mouse forebrain result in a strong and progressive neurodegenerative phenotype which is characterized by both anatomical and behavioral changes.</p> <p>Results</p> <p>To better understand the molecular changes associated with these morphological and behavioral phenotypes, we performed a DNA microarray transcriptome profiling of the hippocampus and the frontal cortex of the <it>PSEN1/PSEN2 </it>double knock-out mice and littermate controls at five different ages ranging from 2–8 months. Our data suggest that combined deficiencies of <it>PSEN1 </it>and <it>PSEN2 </it>results in a progressive, age-dependent transcriptome signature related to neurodegeneration and neuroinflammation. While these events may progress differently in the hippocampus and frontal cortex, the most critical expression signatures are common across the two brain regions, and involve a strong upregulation of <it>cathepsin </it>and <it>complement </it>system transcripts.</p> <p>Conclusion</p> <p>The observed neuroinflammatory expression changes are likely to be causally linked to the neurodegenerative phenotype observed in mice with compound deletions of <it>PSEN1 </it>and <it>PSEN2</it>. Furthermore, our results suggest that the evaluation of inhibitors of PS/γ-secretase activity for treatment of Alzheimer's Disease must include close monitoring for signs of calpain-cathepsin system activation.</p

And then there were four: a study of UK market concentration - causes, consequences and the scope for market adjustment

While concentration measures are a good indicator of market structure, the link with competitiveness is more complex than often assumed. In particular, the modern theory of industrial organisation makes no clear statement regarding the impact of concentration on competition - the focus of this paper is concentration and no inferences are made about competitive aspects of the market. The extent and nature of concentration within the UK listed company audit market as at April, 2002 and, pro forma, after the collapse of Andersen is documented and analysed in detail (by firm, market segment and industry sector). The largest four firms held 90 per cent of the market (based on audit fees) in 2002, rising to 96 per cent with the demise of Andersen. A single firm, Pricewaterhouse-Coopers, held 70 per cent or more of the share of six out of 38 industry sectors, with a share of 50 per cent up to 70 per cent in a further seven sectors. The provision of non-audit services (NAS) by incumbent auditors is also considered. As at April 2002, the average ratio of non-audit fees (paid to auditor) to audit fees was 208 per cent, and exceeded 300 per cent in seven sectors. It is likely, however, that disposals by firms of their management consultancy and outsource firms, combined with the impact of the Smith Report on audit committees will serve to reduce these ratios. Another finding is that audit firms with expertise in a particular sector appeared to earn significantly higher nonaudit fees from their audit clients in that sector. The paper thus provides a solid empirical basis for debate. The subsequent discussion considers the implications for companies and audit firms of the high level of concentration in the current regulatory climate, where no direct regulatory intervention is planned

A Corticothalamic Circuit Trades off Speed for Safety during Decision-Making under Motivational Conflict

Decisions to act while pursuing goals in the presence of danger must be made quickly but safely. Premature decisions risk injury or death, whereas postponing decisions risk goal loss. Here we show how mice resolve these competing demands. Using microstructural behavioral analyses, we identified the spatiotemporal dynamics of approach–avoidance decisions under motivational conflict in male mice. Then we used cognitive modeling to show that these dynamics reflect the speeded decision-making mechanisms used by humans and nonhuman primates, with mice trading off decision speed for safety of choice when danger loomed. Using calcium imaging in paraventricular thalamus and optogenetic inhibition of the prelimbic cortex to paraventricular thalamus pathway, we show that this speed-safety trade off occurs because increases in paraventricular thalamus activity increase decision caution, thereby increasing approach–avoid decision times in the presence of danger. Our findings demonstrate that a discrete brain circuit involving the paraventricular thalamus and its prefrontal input adjusts decision caution during motivational conflict, trading off decision speed for decision safety when danger is close. We identify the corticothalamic pathway as central to cognitive control during decision-making under conflict

Spontaneous induction of the uniform lying helix alignment in bimesogenic liquid crystals for the flexoelectro-optic effect

Using in-plane electric fields, the electrical induction of the uniform lying helix (ULH) alignment in chiral nematic liquid crystals is reported. This process permits spontaneous induction of the ULH alignment to give an in-plane optic axis, without the need for complex processing. Flexoelectro-optic switching is subsequently obtained by holding the in-plane electrodes at a common voltage and addressing via a third, plane-parallel electrode on a second, or upper, substrate to give a field across the device in the viewing direction. For this device, in optimized bimesogenic materials, we demonstrate full intensity modulation and sub-millisecond response times at typical device temperatures. (C) 2012 American Institute of Physics. [doi:10.1063/1.3682305]11Nsciescopu

Slowing light with Fabry-Perot resonator arrays

We analyze the transmission of light through coupled-resonator optical waveguides in the form of evanescently coupled Fabry-Perot resonator arrays. We develop a transfer matrix method to calculate the amplitude and phase responses of the arrays. We also discuss the inclusion of optical gain in the system to compensate for losses in these structures. Owing to the compact length along the propagation direction in evanescently coupled arrays, large slowing factors of the order of 10^2-10^3 can be achieved even with a weak index contrast of ∼0.1%. The large slowing factor, coupled with weak index contrast, makes this structure a promising candidate for artificial slow light system