АНДРОГЕНОВЫЕ РЕЦЕПТОРЫ КАК ФАКТОР ПРОГНОЗА В РАЗЛИЧНЫХ МОЛЕКУЛЯРНО-БИОЛОГИЧЕСКИХ ПОДТИПАХ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ

In the literature there has been increased interest in the study of androgenetic receptors (AR) in different molecular subtypes of breast cancer (BC) but we haven’t found consensus about the role of levels of androgens and their metabolites in samples of biological fluids for the development of breast cancer. Determination of the level of androgenetic receptors in the tumor in patients with breast cancer is very relevant and promising direction in the study of the prognosis of the disease and the search for new complementary approaches to endocrine therapy of breast cancer, especially when basal-like molecular subtype.В литературе отмечается повышенный интерес к изучению андрогеновых рецепторов (АР) при различных молекулярных подтипах рака молочной железы (РМЖ), но мы не нашли единого мнения о влиянии уровня андрогенов и их метаболитов в образцах биологических жидкостей на развитие РМЖ. Определение уровня андрогеновых рецепторов в опухоли у пациенток с раком молочной железы является весьма актуальным и перспективным направлением в изучении прогноза заболевания и поиска новых дополнительных подходов к эндокринной терапии РМЖ, особенно при базальноподобном молекулярном подтипе.

The photometric and spectral investigation of CI Camelopardalis, an X-ray transient and B[e] star

We combined the results of UBVR photometry of CI Cam taken at Sternberg Astronomical Institute in 1998--2001, and moderate resolution spectroscopy taken at Special Astrophysical Observatory during the same time period. Photometry as well as fluxes of Balmer emissions and of some Fe II emission lines of CI Cam in quiet state reveal a cyclic variation with the period of $1100\pm50^d$. The variation like this may be due to an orbital motion in a wide pair with a giant star companion that exhibits the reflection effect on its side faced to a compact companion. The V-band photometry also confirms the pre-outburst 11.7 day period found by Miroshnichenko earlier, but with a lower amplitude of 3 per cent. The possibility of identity of this photometric period with the period of jet's rotation in the VLA radio map of the object CI Cam was investigated. The radio map modelling reveals the inclination of the jet rotation axis to the line of sight, $i = 35-40^o$, the angle between the rotation axis and the direction of ejection of the jet, $\theta = 7-10^o$, and jet's spatial velocity of 0.23--0.26c. Equivalent widths and fluxes of various spectral lines show different amplitudes of changes during the outburst, and essentially distinct behaviour in quiescence. Five types of such behaviour were revealed, that indicates the strong stratification of a gas and dust envelope round the system . The time lag of strengthening of 50--250$^d$ in the forbidden line of nitrogen [N II] was found relatively to the X-ray outburst maximum.Comment: 15 pages, 8 figures, 3 tables, Astron. Zh., 2002, (in press), vol.79, number

Spectroscopic observations of the candidate sgB[e]/X-ray binary CI Cam

We present a compilation of spectroscopic observations of the sgB[e] star CI Cam. This includes data from before, during, and after its 1998 outburst. The object shows a rich emission line spectrum originating from circumstellar material, rendering it difficult to determine the nature of either star involved or the cause of the outburst. We collate pre-outburst data to determine the state of the system before this occurred and provide a baseline for comparison with later data. During the outburst all lines become stronger, and hydrogen and helium lines become significantly broader and asymmetric. After the outburst, spectral changes persist for at least three years, with FeII and [NII] lines still a factor of ~2 above the pre-outburst level and HeI, HeII, and NII lines suppressed by a factor of 2-10. We find that the spectral properties of CI Cam are similar to other sgB[e] stars and therefore suggest that the geometry of the circumstellar material is similar to that proposed for the other objects: a two component outflow, with a fast, hot, rarefied polar wind indistinguishable from that of a normal supergiant and a dense, cooler equatorial outflow with a much lower velocity. We suggest that CI Cam is among the hotter members of the class and is viewed nearly pole-on. The nature of the compact object and the mechanism for the outburst remain uncertain, although it is likely that the compact object is a black hole or neutron star, and that the outburst was precipitated by its passage through the equatorial material. We suggest that this prompted a burst of supercritical accretion resulting in ejection of much of the material, which was later seen as an expanding radio remnant. [Abbreviated]Comment: 25 pages including figures. Accepted for publication in A&

Heterogeneous treatment effects of therapeutic-dose heparin in patients hospitalized for COVID-19

Importance Randomized clinical trials (RCTs) of therapeutic-dose heparin in patients hospitalized with COVID-19 produced conflicting results, possibly due to heterogeneity of treatment effect (HTE) across individuals. Better understanding of HTE could facilitate individualized clinical decision-making. Objective To evaluate HTE of therapeutic-dose heparin for patients hospitalized for COVID-19 and to compare approaches to assessing HTE. Design, Setting, and Participants Exploratory analysis of a multiplatform adaptive RCT of therapeutic-dose heparin vs usual care pharmacologic thromboprophylaxis in 3320 patients hospitalized for COVID-19 enrolled in North America, South America, Europe, Asia, and Australia between April 2020 and January 2021. Heterogeneity of treatment effect was assessed 3 ways: using (1) conventional subgroup analyses of baseline characteristics, (2) a multivariable outcome prediction model (risk-based approach), and (3) a multivariable causal forest model (effect-based approach). Analyses primarily used bayesian statistics, consistent with the original trial. Exposures Participants were randomized to therapeutic-dose heparin or usual care pharmacologic thromboprophylaxis. Main Outcomes and Measures Organ support–free days, assigning a value of −1 to those who died in the hospital and the number of days free of cardiovascular or respiratory organ support up to day 21 for those who survived to hospital discharge; and hospital survival. Results Baseline demographic characteristics were similar between patients randomized to therapeutic-dose heparin or usual care (median age, 60 years; 38% female; 32% known non-White race; 45% Hispanic). In the overall multiplatform RCT population, therapeutic-dose heparin was not associated with an increase in organ support–free days (median value for the posterior distribution of the OR, 1.05; 95% credible interval, 0.91-1.22). In conventional subgroup analyses, the effect of therapeutic-dose heparin on organ support–free days differed between patients requiring organ support at baseline or not (median OR, 0.85 vs 1.30; posterior probability of difference in OR, 99.8%), between females and males (median OR, 0.87 vs 1.16; posterior probability of difference in OR, 96.4%), and between patients with lower body mass index (BMI 90% for all comparisons). In risk-based analysis, patients at lowest risk of poor outcome had the highest propensity for benefit from heparin (lowest risk decile: posterior probability of OR >1, 92%) while those at highest risk were most likely to be harmed (highest risk decile: posterior probability of OR <1, 87%). In effect-based analysis, a subset of patients identified at high risk of harm (P = .05 for difference in treatment effect) tended to have high BMI and were more likely to require organ support at baseline. Conclusions and Relevance Among patients hospitalized for COVID-19, the effect of therapeutic-dose heparin was heterogeneous. In all 3 approaches to assessing HTE, heparin was more likely to be beneficial in those who were less severely ill at presentation or had lower BMI and more likely to be harmful in sicker patients and those with higher BMI. The findings illustrate the importance of considering HTE in the design and analysis of RCTs. Trial Registration ClinicalTrials.gov Identifiers: NCT02735707, NCT04505774, NCT04359277, NCT0437258

ANDROGEN RECEPTORS AS A FACTOR OF PROGNOSIS IN VARIOUS MOLECULAR-BIOLOGICAL SUBTYPES OF BREAST CANCER

In the literature there has been increased interest in the study of androgenetic receptors (AR) in different molecular subtypes of breast cancer (BC) but we haven’t found consensus about the role of levels of androgens and their metabolites in samples of biological fluids for the development of breast cancer. Determination of the level of androgenetic receptors in the tumor in patients with breast cancer is very relevant and promising direction in the study of the prognosis of the disease and the search for new complementary approaches to endocrine therapy of breast cancer, especially when basal-like molecular subtype

Breast sarcomas. Literature review

The article presents an overview of the literature about breast sarcomas (nonepithelial malignances). Primary sarcomas are extremely rare, with less than 1 % of all malignant tumors of the breast. Breast carcinomas cause an increased interest of the scientists due to their unique clinical and pathological features and unpredictable prognosis

New design modifications of the supporting ring for a large deployable space reflector

Twee orginele ontwerp modificaties worden beschreven voor circulaire symmetrische apertuur (radio telescoop) antennes