CONSTRAIN-BASED PARTICLE SWARM OPTIMIZATION (CBPSO) FOR CALL CENTER SCHEDULING

[[abstract]]Achieving efficient and optimized call center scheduling is a critical issue to corporate customer services when considering limited resources and complex constraints. This study combines constraint-based reasoning (CDR) mechanisms and particle swarm optimization (PSO) (CBPSO) to solve timetables scheduling problems for customer service department. When PSO searches for solution space, CBR mechanism can be used to reduce invalid solution space of particle search, and to improve solving efficiency. The experimental results showed that CBPSO is able to overcome the efficiency and flexibly concern under constraints in developing work-force timetables. The produced scheduling timetables can also address the labor cost minimization and fairness maximization

Optimal Receiver Antenna Location in Indoor Environment Using Dynamic Differential Evolution and Genetic Algorithm

[[abstract]]Using the impulse responses of these multipath channels, the bit error rate (BER) performance for binary pulse amplitude modulation impulse radio ultra-wideband communication system is calculated. The optimization location of receiving antenna is investigated by dynamic differential evolution (DDE) and genetic algorithm (GA) to minimize the outage probability. Numerical results show that the performance for reducing BER and outage probability by DDE algorithm is better than that by GA.[[notice]]補正完畢[[incitationindex]]SCI[[booktype]]紙本[[booktype]]電子

Intelligent Tele-Homecare: The Application of Soft-Computing Models in Sensor Agent Network Systems

This paper conceptualises the development of an Intelligent Home Care system to assist health care professionals and carers in providing an enhanced level of support to senior citizens. The social demographics in the developed world indicate a decline in population growth, indicating a need for greater resources to be dedicated towards enhancing the lives of an aging society. Furthermore, the dissociation of extended family structures in modern society results in senior citizens to take greater independence in managing their own lives. With the technological advances in the Tele-Homecare domain, there is an impetus to develop improved computational techniques that reflect the nature of complex systems in medicine and biology

Association Patterns of Ontological Features Signify Electronic Health Records in Liver Cancer

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Lack of the transcription factor hypoxia-inducible factor (HIF)-1α in macrophages accelerates the necrosis of Mycobacterium avium-induced granulomas

Accepted ManuscriptThe establishment of mycobacterial infection is characterized by the formation of granulomas, which are well-organized aggregates of immune cells, namely, infected macrophages. The granuloma's main function is to constrain and prevent dissemination of the mycobacteria while focusing the immune response to a limited area. In some cases these lesions can grow progressively into large granulomas which can undergo central necrosis, thereby leading to their caseation. Macrophages are the most abundant cells present in the granuloma and are known to adapt under hypoxic conditions in order to avoid cell death. Our laboratory has developed a granuloma necrosis model that mimics the human pathology of Mycobacterium tuberculosis, using C57BL/6 mice infected intravenously with a low dose of a highly virulent strain of Mycobacterium avium. In this work, a mouse strain deleted of the hypoxia inducible factor 1a (HIF-1a) under the Cre-lox system regulated by the lysozyme M gene promoter was used to determine the relevance of HIF-1a in the caseation of granulomas. The genetic ablation of HIF-1a in the myeloid lineage causes the earlier emergence of granuloma necrosis and clearly induces an impairment of the resistance against M. avium infection coincident with the emergence of necrosis. The data provide evidence that granulomas become hypoxic before undergoing necrosis through the analysis of vascularization and quantification of HIF-1a in a necrotizing mouse model. Our results show that interfering with macrophage adaptation to hypoxia, such as through HIF-1a inactivation, accelerates granuloma necrosis.Support from national funds through FCT/MEC (Fundação para a Ciência e a Tecnologia/Ministério da Educação e Ciência), when applicable cofunded by FEDER funds within the partnership agreement PT2020 related to the research unit number 4293; from “NORTE-07-0124-FEDER-000002-Host-Pathogen Interactions,” cofunded by Programa Operacional Regional do Norte (ON.2–O Novo Norte), under the Quadro de Referência Estratégico Nacional (QREN); and from HMSP-ICT/0024/2010. T.M.S. received postdoctoral grant ON2201310 from “NORTE-07-0124-FEDER-000002-Host-Pathogen Interactions,” cofunded by Programa Operacional Regional do Norte (ON.2–O Novo Norte), under the Quadro de Referência Estratégico Nacional (QREN). M.R. received Ph.D. grant SFRH/BD/89871/2012 from FCT, Portuga

Implementing guidelines for the prescribing of vancomycin and teicoplanin

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The Carbon_h-Factor: Predicting Individuals' Research Impact at Early Stages of Their Career

Assessing an individual's research impact on the basis of a transparent algorithm is an important task for evaluation and comparison purposes. Besides simple but also inaccurate indices such as counting the mere number of publications or the accumulation of overall citations, and highly complex but also overwhelming full-range publication lists in their raw format, Hirsch (2005) introduced a single figure cleverly combining different approaches. The so-called h-index has undoubtedly become the standard in scientometrics of individuals' research impact (note: in the present paper I will always use the term “research impact” to describe the research performance as the logic of the paper is based on the h-index, which quantifies the specific “impact” of, e.g., researchers, but also because the genuine meaning of impact refers to quality as well). As the h-index reflects the number h of papers a researcher has published with at least h citations, the index is inherently positively biased towards senior level researchers. This might sometimes be problematic when predictive tools are needed for assessing young scientists' potential, especially when recruiting early career positions or equipping young scientists' labs. To be compatible with the standard h-index, the proposed index integrates the scientist's research age (Carbon_h-factor) into the h-index, thus reporting the average gain of h-index per year. Comprehensive calculations of the Carbon_h-factor were made for a broad variety of four research-disciplines (economics, neuroscience, physics and psychology) and for researchers performing on three high levels of research impact (substantial, outstanding and epochal) with ten researchers per category. For all research areas and output levels we obtained linear developments of the h-index demonstrating the validity of predicting one's later impact in terms of research impact already at an early stage of their career with the Carbon_h-factor being approx. 0.4, 0.8, and 1.5 for substantial, outstanding and epochal researchers, respectively

Experimental Zika Virus Infection in the Pregnant Common Marmoset Induces Spontaneous Fetal Loss and Neurodevelopmental Abnormalities.

During its most recent outbreak across the Americas, Zika virus (ZIKV) was surprisingly shown to cause fetal loss and congenital malformations in acutely and chronically infected pregnant women. However, understanding the underlying pathogenesis of ZIKV congenital disease has been hampered by a lack of relevant in vivo experimental models. Here we present a candidate New World monkey model of ZIKV infection in pregnant marmosets that faithfully recapitulates human disease. ZIKV inoculation at the human-equivalent of early gestation caused an asymptomatic seroconversion, induction of type I/II interferon-associated genes and proinflammatory cytokines, and persistent viremia and viruria. Spontaneous pregnancy loss was observed 16-18 days post-infection, with extensive active placental viral replication and fetal neurocellular disorganization similar to that seen in humans. These findings underscore the key role of the placenta as a conduit for fetal infection, and demonstrate the utility of marmosets as a highly relevant model for studying congenital ZIKV disease and pregnancy loss

The role of the School Librarians as Information Literacy Specialists: a comparative study between Hong Kong, Shanghai, South Korea, Taipei, and Japan

Theme: The Educational Role of School Libraries in the M Generation主題 -- 學校圖書館在M世代的教育角色學校圖書館主任不僅是圖書館的管理人員，現今他們也擔負了教學、顧問、行政、資訊專家和資訊素養導師等角色；然而在亞洲國家，學校圖書館主任的這些角色與貢獻卻未被認定，其中尤以作為資訊素養專家的這個角色特別不受認可與重視。因此本研究的主要在分析比較學校圖書館主任作為資訊素養導師這個角色，在亞洲不同地區的情況與差異。本研究在香港、 日本、 上海、 韓國、及台北五個地區共收集了466 位學校圖書館主任的調查問卷。分析結果發現，圖書館主任在資訊素養方面擔當的範圍和參與度，台北和南韓方面的表現優於其他地區，尤其台北學校圖書館的人員編制和組織結構更傾向富裕和部門化。分析結果同時顯示學校圖書館主任進行資訊素養教育的數量，與他們和其他學科教師的協作，以及他們作為資訊顧問和對整體教學的貢獻成正比。此外學校圖書館主任提供參考服務的數量和程度以支援其他學科教師教學，是他們主要的貢獻。postprin