Evaluation of accuracy of various impression techniques and impression materials in recording multiple implants placed unilaterally in a partially edentulous mandible- An in vitro study

Various factors like implant angulation, type of impression material and tray type affects the implant impression accuracy. To date limited in-vitro studies were carried out on the implant impression accuracy of unilateral partially edentulous arches. The aim of this research was to evaluate the effects of 0o, 15o and 25o implant angulations on impression accuracy in simulated master casts of unilateral partially edentulous situation using different impression materials and tray selections. 30 replicas (N = 30) of a resin matrix (control) containing four implant analogues placed unilaterally from the midline till the region of second molar at an angulation of 00, 00, 150 and 250 to the vertical axis of the ridge respectively were obtained by using three impression techniques (stock metal tray, closed custom tray, and open nonsplinted custom tray) and two different impression materials (Polyvinyl-siloxane and polyether). Specific dimensions of the resultant casts were measured using coordinated measuring microscope. Mean linear changes were calculated and statistically analyzed using analysis of variance (ANOVA) and Tukey?s post-hoc procedures (p< 0.05). The casts obtained from all three impression techniques had significant differences in dimensions (p<0.05) as compared to that of master model irrespective of impression materials. Comparing the techniques with regard to the parallel implants, no statistical significant difference (p<0.05) was observed with custom tray techniques (closed/open). Whereas while comparing parallel versus non parallel, open tray technique showed superior accuracy compared to closed tray technique as the angulation increased more than 15 degrees. The influence of material and technique appeared to be significant for highly non axial implant angulations (p< 0.05), and increased angulation tended to decrease impression accuracy. The open tray technique was more accurate with highly nonaxially oriented implants for the small sample size investigated

Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight:a systematic review and meta-analysis

Background: Vitamin B-12 and folate are micronutrients essential for normal embryogenesis. Vitamin B-12 insufficiency in pregnancy is high in certain parts of the world, such as India, and although this has been linked to low birth weight (LBW) in these populations, the relation between vitamin B-12 and birth weight (BW) elsewhere is unknown. Objectives: We performed a systematic review to assess 1) the worldwide prevalence of vitamin B-12 insufficiency in pregnancy and 2) its association with BW. Design: A search of 5 electronic databases was performed to identify eligible articles. Random-effects meta-analysis was conducted according to geographic regions and pregnancy trimesters for the prevalence subreview and by categorical measures of BW. Results: A total of 57 and 23 articles were included for the prevalence and BW subreviews, respectively. The pooled estimates of vitamin B-12 insufficiency were 21%, 19%, and 29% in the first, second, and third trimesters, respectively, with high rates for the Indian subcontinent and the Eastern Mediterranean. The large heterogeneity between studies was partially addressed by creating a standardized score for each study (mean vitamin B-12 insufficiency ÷ cutoff value), which internally corrected for geographic region, trimester, and assay type. Twelve of the 13 longitudinal studies included showed a decrease in mean or median vitamin B-12 across trimesters. Pooled analysis showed nonsignificantly lower maternal vitamin B-12 concentrations in LBW than in normal-BW infants and higher odds of LBW with lower vitamin B-12 values (adjusted OR: 1.70; 95% CI: 1.16, 2.50), but studies from India largely contributed to the latter. Conclusions: Our review indicates that vitamin B-12 insufficiency during pregnancy is common even in nonvegetarian populations and that concentrations of vitamin B-12 decrease from the first to the third trimester. There is no consistent association between vitamin B-12 insufficiency and LBW. However, given the long-term risks of LBW, this observation warrants further cohort studies and randomized controlled trials

A Ni(II) dinuclear complex bridged by end-on azide-N and phenolate-O atoms: spectral interpretation, magnetism and biological study

A new dinuclear complex, [Ni(L)(μ1,1-N3)Ni(L)(OH2)2]·ClO4(1), has been synthesized. It shows the presence of ferromagnetic interactions and is endowed with both anti-mycobacterial and anticancer properties

Transition Pathways to Sustainable Agricultural Water Management: A Review of Integrated Modeling Approaches

Agricultural water management (AWM) is an interdisciplinary concern, cutting across traditional domains such as agronomy, climatology, geology, economics, and sociology. Each of these disciplines has developed numerous process-based and empirical models for AWM. However, models that simulate all major hydrologic, water quality, and crop growth processes in agricultural systems are still lacking. As computers become more powerful, more researchers are choosing to integrate existing models to account for these major processes rather than building new cross-disciplinary models. Model integration carries the hope that, as in a real system, the sum of the model will be greater than the parts. However, models based upon simplified and unrealistic assumptions of physical or empirical processes can generate misleading results which are not useful for informing policy. In this article, we use literature and case studies from the High Plains Aquifer and Southeastern United States regions to elucidate the challenges and opportunities associated with integrated modeling for AWM and recommend conditions in which to use integrated models. Additionally, we examine the potential contributions of integrated modeling to AWM — the actual practice of conserving water while maximizing productivity

Overview of the PAN/CLEF 2015 Evaluation Lab

The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-319-24027-5_49This paper presents an overview of the PAN/CLEF evaluation lab. During the last decade, PAN has been established as the main forum of text mining research focusing on the identification of personal traits of authors left behind in texts unintentionally. PAN 2015 comprises three tasks: plagiarism detection, author identification and author profiling studying important variations of these problems. In plagiarism detection, community-driven corpus construction is introduced as a new way of developing evaluation resources with diversity. In author identification, cross-topic and cross-genre author verification (where the texts of known and unknown authorship do not match in topic and/or genre) is introduced. A new corpus was built for this challenging, yet realistic, task covering four languages. In author profiling, in addition to usual author demographics, such as gender and age, five personality traits are introduced (openness, conscientiousness, extraversion, agreeableness, and neuroticism) and a new corpus of Twitter messages covering four languages was developed. In total, 53 teams participated in all three tasks of PAN 2015 and, following the practice of previous editions, software submissions were required and evaluated within the TIRA experimentation framework.Stamatatos, E.; Potthast, M.; Rangel, F.; Rosso, P.; Stein, B. (2015). Overview of the PAN/CLEF 2015 Evaluation Lab. En Experimental IR Meets Multilinguality, Multimodality, and Interaction: 6th International Conference of the CLEF Association, CLEF'15, Toulouse, France, September 8-11, 2015, Proceedings. Springer International Publishing. 518-538. doi:10.1007/978-3-319-24027-5_49S518538Álvarez-Carmona, M.A., López-Monroy, A.P., Montes-Y-Gómez, M., Villaseñor-Pineda, L., Jair-Escalante, H.: INAOE’s participation at PAN 2015: author profiling task–notebook for PAN at CLEF 2015. In: CLEF 2013 Working Notes. CEUR (2015)Argamon, S., Koppel, M., Fine, J., Shimoni, A.R.: Gender, Genre, and Writing Style in Formal Written Texts. TEXT 23, 321–346 (2003)Bagnall, D.: Author identification using multi-headed recurrent neural networks. In: CLEF 2015 Working Notes. CEUR (2015)Burger, J.D., Henderson, J., Kim, G., Zarrella, G.: Discriminating gender on twitter. In: Proceedings of EMNLP 2011. ACL (2011)Burrows, S., Potthast, M., Stein, B.: Paraphrase Acquisition via Crowdsourcing and Machine Learning. ACM TIST 4(3), 43:1–43:21 (2013)Castillo, E., Cervantes, O., Vilariño, D., Pinto, D., León, S.: Unsupervised method for the authorship identification task. 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In: CLEF 2014 Labs and Workshops, Notebook Papers. CEUR (2014)Gollub, T., Potthast, M., Beyer, A., Busse, M., Rangel, F., Rosso, P., Stamatatos, E., Stein, B.: Recent trends in digital text forensics and its evaluation. In: Forner, P., Müller, H., Paredes, R., Rosso, P., Stein, B. (eds.) CLEF 2013. LNCS, vol. 8138, pp. 282–302. Springer, Heidelberg (2013)Gollub, T., Stein, B., Burrows, S.: Ousting ivory tower research: towards a web framework for providing experiments as a service. In: Proceedings of SIGIR 2012. ACM (2012)Hagen, M., Potthast, M., Stein, B.: Source retrieval for plagiarism detection from large web corpora: recent approaches. In: CLEF 2015 Working Notes. CEUR (2015)van Halteren, H.: Linguistic profiling for author recognition and verification. In: Proceedings of ACL 2004. ACL (2004)Holmes, J., Meyerhoff, M.: The Handbook of Language and Gender. Blackwell Handbooks in Linguistics. Wiley (2003)Jankowska, M., Keselj, V., Milios, E.: CNG text classification for authorship profiling task–notebook for PAN at CLEF 2013. In: CLEF 2013 Working Notes. CEUR (2013)Juola, P.: Authorship Attribution. Foundations and Trends in Information Retrieval 1, 234–334 (2008)Juola, P.: How a Computer Program Helped Reveal J.K. Rowling as Author of A Cuckoo’s Calling. Scientific American (2013)Juola, P., Stamatatos, E.: Overview of the author identification task at PAN-2013. In: CLEF 2013 Working Notes. CEUR (2013)Kalimeri, K., Lepri, B., Pianesi, F.: Going beyond traits: multimodal classification of personality states in the wild. In: Proceedings of ICMI 2013. ACM (2013)Koppel, M., Argamon, S., Shimoni, A.R.: Automatically Categorizing Written Texts by Author Gender. Literary and Linguistic Computing 17(4) (2002)Koppel, M., Schler, J., Bonchek-Dokow, E.: Measuring Differentiability: Unmasking Pseudonymous Authors. J. Mach. Learn. Res. 8, 1261–1276 (2007)Koppel, M., Winter, Y.: Determining if Two Documents are Written by the same Author. Journal of the American Society for Information Science and Technology 65(1), 178–187 (2014)Kosinski, M., Bachrach, Y., Kohli, P., Stillwell, D., Graepel, T.: Manifestations of User Personality in Website Choice and Behaviour on Online Social Networks. Machine Learning (2013)López-Monroy, A.P., y Gómez, M.M., Jair-Escalante, H., Villaseñor-Pineda, L.: Using intra-profile information for author profiling–notebook for PAN at CLEF 2014. In: CLEF 2014 Working Notes. CEUR (2014)Lopez-Monroy, A.P., Montes-Y-Gomez, M., Escalante, H.J., Villasenor-Pineda, L., Villatoro-Tello, E.: INAOE’s participation at PAN 2013: author profiling task-notebook for PAN at CLEF 2013. In: CLEF 2013 Working Notes. CEUR (2013)Luyckx, K., Daelemans, W.: Authorship attribution and verification with many authors and limited data. In: Proceedings of COLING 2008 (2008)Maharjan, S., Shrestha, P., Solorio, T., Hasan, R.: A straightforward author profiling approach in mapreduce. In: Bazzan, A.L.C., Pichara, K. (eds.) IBERAMIA 2014. LNCS, vol. 8864, pp. 95–107. Springer, Heidelberg (2014)Mairesse, F., Walker, M.A., Mehl, M.R., Moore, R.K.: Using Linguistic Cues for the Automatic Recognition of Personality in Conversation and Text. Journal of Artificial Intelligence Research 30(1), 457–500 (2007)Eissen, S.M., Stein, B.: Intrinsic plagiarism detection. In: Lalmas, M., MacFarlane, A., Rüger, S.M., Tombros, A., Tsikrika, T., Yavlinsky, A. (eds.) ECIR 2006. LNCS, vol. 3936, pp. 565–569. Springer, Heidelberg (2006)Mohammadi, G., Vinciarelli, A.: Automatic personality perception: Prediction of Trait Attribution Based on Prosodic Features. IEEE Transactions on Affective Computing 3(3), 273–284 (2012)Moreau, E., Jayapal, A., Lynch, G., Vogel, C.: Author verification: basic stacked generalization applied to predictions from a set of heterogeneous learners. In: CLEF 2015 Working Notes. CEUR (2015)Nguyen, D., Gravel, R., Trieschnigg, D., Meder, T.: “How old do you think I am?”; a study of language and age in twitter. In: Proceedings of ICWSM 2013. AAAI (2013)Oberlander, J., Nowson, S.: Whose thumb is it anyway?: classifying author personality from weblog text. In: Proceedings of COLING 2006. ACL (2006)Peñas, A., Rodrigo, A.: A simple measure to assess non-response. In: Proceedings of HLT 2011. ACL (2011)Pennebaker, J.W., Mehl, M.R., Niederhoffer, K.G.: Psychological Aspects of Natural Language Use: Our Words. Our Selves. Annual Review of Psychology 54(1), 547–577 (2003)Potthast, M., Barrón-Cedeño, A., Eiselt, A., Stein, B., Rosso, P.: Overview of the 2nd international competition on plagiarism detection. In: CLEF 2010 Working Notes. CEUR (2010)Potthast, M., Barrón-Cedeño, A., Stein, B., Rosso, P.: Cross-Language Plagiarism Detection. Language Resources and Evaluation (LRE) 45, 45–62 (2011)Potthast, M., Eiselt, A., Barrón-Cedeño, A., Stein, B., Rosso, P.: Overview of the 3rd international competition on plagiarism detection. In: CLEF 2011 Working Notes (2011)Potthast, M., Gollub, T., Hagen, M., Graßegger, J., Kiesel, J., Michel, M., Oberländer, A., Tippmann, M., Barrón-Cedeño, A., Gupta, P., Rosso, P., Stein, B.: Overview of the 4th international competition on plagiarism detection. In: CLEF 2012 Working Notes. CEUR (2012)Potthast, M., Gollub, T., Hagen, M., Tippmann, M., Kiesel, J., Rosso, P., Stamatatos, E., Stein, B.: Overview of the 5th international competition on plagiarism detection. In: CLEF 2013 Working Notes. CEUR (2013)Potthast, M., Gollub, T., Rangel, F., Rosso, P., Stamatatos, E., Stein, B.: Improving the reproducibility of PAN’s shared tasks: plagiarism detection, author identification, and author profiling. In: Kanoulas, E., Lupu, M., Clough, P., Sanderson, M., Hall, M., Hanbury, A., Toms, E. (eds.) CLEF 2014. LNCS, vol. 8685, pp. 268–299. Springer, Heidelberg (2014)Potthast, M., Hagen, M., Beyer, A., Busse, M., Tippmann, M., Rosso, P., Stein, B.: Overview of the 6th international competition on plagiarism detection. In: CLEF 2014 Working Notes. CEUR (2014)Potthast, M., Göring, S., Rosso, P., Stein, B.: Towards data submissions for shared tasks: first experiences for the task of text alignment. In: CLEF 2015 Working Notes. CEUR (2015)Potthast, M., Hagen, M., Stein, B., Graßegger, J., Michel, M., Tippmann, M., Welsch, C.: ChatNoir: a search engine for the clueweb09 corpus. In: Proceedings of SIGIR 2012. 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Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity

The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or IDH2-R172K). Approximately 70% of ODGs with 1p19q co-deletions harbor somatic mutations in the Capicua Transcriptional Repressor (CIC) gene on chromosome 19q13.2. Here we show that endogenous long (CIC-L) and short (CIC-S) CIC proteins are predominantly localized to the nucleus or cytoplasm, respectively. Cytoplasmic CIC-S is found in close proximity to the mitochondria. To study wild type and mutant CIC function and motivated by the paucity of 1p19q co-deleted ODG lines, we created HEK293 and HOG stable cell lines ectopically co-expressing CIC and IDH1. Non-mutant lines displayed increased clonogenicity, but cells co-expressing the mutant IDH1-R132H with either CIC-S-R201W or -R1515H showed reduced clonogenicity in an additive manner, demonstrating cooperative effects in our assays. Expression of mutant CIC-R1515H increased cellular 2-Hydroxyglutarate (2HG) levels compared to wild type CIC in IDH1-R132H background. Levels of phosphorylated ATP-citrate Lyase (ACLY) were lower in cell lines expressing mutant CIC-S proteins compared to cells expressing wild type CIC-S, supporting a cytosolic citrate metabolism-related mechanism of reduced clonogenicity in our in vitro model systems. ACLY or phospho-ACLY were similarly reduced in CIC-mutant 1p19q co-deleted oligodendroglioma patient samples

FIGO staging for carcinoma of the vulva : 2021 revision

To revise the FIGO staging for carcinoma of the vulva using a new approach that involves analyses of prospectively collected data. The FIGO Committee for Gynecologic Oncology reviewed the recent literature to gain an insight into the impact of the 2009 vulvar cancer staging revision. The Committee resolved to revise the staging with a goal of simplification and actively collaborated with the United States National Cancer Database to analyze prospectively collected data on carcinoma of the vulva. Many tumor characteristics were collected for all stages of vulvar cancer treated between 2010 and 2017. Statistical analysis was performed with SAS software. Overall survival was estimated based on tumor characteristics. Log-rank and Wilcoxon tests were used to analyze overall survival similarities between and within groups of tumor characteristics. Characteristics with similar survivals were then grouped into the same stages and substages. Kaplan–Meier overall survival curves were generated for the resulting stages and substages. There were 12 063 cases with available data. The resulting new staging for carcinoma of the vulva has two substages in Stage I, no substage in Stage II, three substages in Stage III, and two substages in Stage IV. The Kaplan–Meier overall survival curves showed clear separation between stages and substages. The 2021 vulvar cancer staging is the first from the FIGO Committee for Gynecologic Oncology to be derived from data analyses. This revision has a new definition for depth of invasion, uses the same definition for lymph node metastases utilized in cervical cancer, and allows findings from cross-sectional imaging to be incorporated into vulvar cancer staging. The 2021 FIGO staging for carcinoma of the vulva is data-derived, validated, and much simpler than earlier revisions.The American College of Surgeons’ (ACoS) Commission on Cancer (CoC) and National Cancer Database (NCDB).http://www.wileyonlinelibrary.com/journal/ijgohj2022Obstetrics and Gynaecolog

Loss of CIC promotes mitotic dysregulation and chromosome segregation defects

Background: CIC is a transcriptional repressor inactivated by loss-of-function mutations in several cancer types, including gliomas, lung cancers, and gastric adenocarcinomas. CIC alterations and/or loss of CIC activity have been associated with poorer outcomes and more aggressive phenotypes across cancer types, which is consistent with the notion that CIC functions as a tumour suppressor across a wide range of contexts. Results: Using mammalian cells lacking functional CIC, we found that CIC deficiency was associated with chromosome segregation (CS) defects, resulting in chromosomal instability and aneuploidy. These CS defects were associated with transcriptional dysregulation of spindle assembly checkpoint and cell cycle regulators. We also identified novel CIC interacting proteins, including core members of the SWI/SNF complex, and showed that they cooperatively regulated the expression of genes involved in cell cycle regulation. Finally, we showed that loss of CIC and ARID1A cooperatively increased CS defects and reduced cell viability. Conclusions: Our study ascribes a novel role to CIC as an important regulator of the cell cycle and demonstrates that loss of CIC can lead to chromosomal instability and aneuploidy in human and murine cells through defects in CS, providing insight into the underlying mechanisms of CIC's increasingly apparent role as a "pan-cancer" tumour suppressor

Loss of CIC promotes mitotic dysregulation and chromosome segregation defects

Background: CIC is a transcriptional repressor inactivated by loss-of-function mutations in several cancer types, including gliomas, lung cancers, and gastric adenocarcinomas. CIC alterations and/or loss of CIC activity have been associated with poorer outcomes and more aggressive phenotypes across cancer types, which is consistent with the notion that CIC functions as a tumour suppressor across a wide range of contexts. Results: Using mammalian cells lacking functional CIC, we found that CIC deficiency was associated with chromosome segregation (CS) defects, resulting in chromosomal instability and aneuploidy. These CS defects were associated with transcriptional dysregulation of spindle assembly checkpoint and cell cycle regulators. We also identified novel CIC interacting proteins, including core members of the SWI/SNF complex, and showed that they cooperatively regulated the expression of genes involved in cell cycle regulation. Finally, we showed that loss of CIC and ARID1A cooperatively increased CS defects and reduced cell viability. Conclusions: Our study ascribes a novel role to CIC as an important regulator of the cell cycle and demonstrates that loss of CIC can lead to chromosomal instability and aneuploidy in human and murine cells through defects in CS, providing insight into the underlying mechanisms of CIC's increasingly apparent role as a "pan-cancer" tumour suppressor

Understanding the interplay between social and spatial behaviour

According to personality psychology, personality traits determine many aspects of human behaviour. However, validating this insight in large groups has been challenging so far, due to the scarcity of multi-channel data. Here, we focus on the relationship between mobility and social behaviour by analysing trajectories and mobile phone interactions of ∼1000 individuals from two high-resolution longitudinal datasets. We identify a connection between the way in which individuals explore new resources and exploit known assets in the social and spatial spheres. We show that different individuals balance the exploration-exploitation trade-off in different ways and we explain part of the variability in the data by the big five personality traits. We point out that, in both realms, extraversion correlates with the attitude towards exploration and routine diversity, while neuroticism and openness account for the tendency to evolve routine over long time-scales. We find no evidence for the existence of classes of individuals across the spatio-social domains. Our results bridge the fields of human geography, sociology and personality psychology and can help improve current models of mobility and tie formation