Traveling waves for nonlinear Schr\"odinger equations with nonzero conditions at infinity, II

We prove the existence of nontrivial finite energy traveling waves for a large class of nonlinear Schr\"odinger equations with nonzero conditions at infinity (includindg the Gross-Pitaevskii and the so-called "cubic-quintic" equations) in space dimension $N \geq 2$. We show that minimization of the energy at fixed momentum can be used whenever the associated nonlinear potential is nonnegative and it gives a set of orbitally stable traveling waves, while minimization of the action at constant kinetic energy can be used in all cases. We also explore the relationship between the families of traveling waves obtained by different methods and we prove a sharp nonexistence result for traveling waves with small energy.Comment: Final version, accepted for publication in the {\it Archive for Rational Mechanics and Analysis.} The final publication is available at Springer via http://dx.doi.org/10.1007/s00205-017-1131-

A Preliminary Study of Image Analysis for Parasite Detection on Honey Bees

International Conference Image Analysis and Recognition (ICIAR 2018, Póvoa de Varzim, Portugal

From image to technology: a multidisciplinary approach for improving the quality of organic bread.

This study is part of a research programme devoted to improving the quality of organic bread. It aims to identify and test prototypes of breads approved by consumers. This is achieved by analysing consumer representations and preferences and placing them within the framework of technological, sensory and nutritional dimensions of the products. The multidisciplinary approach implements an original qualitative approach that combines three consumer focus groups made up of both loyal and occasional consumers, and confrontation sessions with the programme scientific partners. Four prototypes of organic breads have thus been formalised and subsequently tested on a sample of 120 consumers from two sites (Angers and Strasbourg). From an operational point of view, proposals for organic breads approved by consumers are formulated. In terms of methodology, the contributions of a multidisciplinary study are discussed

Application of tandem two-dimensional mass spectrometry for top-down deep sequencing of calmodulin

Two-dimensional mass spectrometry (2DMS) involves simultaneous acquisition of the fragmentation patterns of all the analytes in a mixture by correlating their precursor and fragment ions by modulating precursor ions systematically through a fragmentation zone. Tandem two-dimensional mass spectrometry (MS/2DMS) unites the ultra-high accuracy of Fourier transform ion cyclotron resonance (FT-ICR) MS/MS and the simultaneous data-independent fragmentation of 2DMS to achieve extensive inter-residue fragmentation of entire proteins. 2DMS was recently developed for top-down proteomics (TDP), and applied to the analysis of calmodulin (CaM), reporting a cleavage coverage of about ~23% using infrared multiphoton dissociation (IRMPD) as fragmentation technique. The goal of this work is to expand the utility of top-down protein analysis using MS/2DMS in order to extend the cleavage coverage in top-down proteomics further into the interior regions of the protein. In this case, using MS/2DMS, the cleavage coverage of CaM increased from ~23% to ~42%

Successful private–public funding of paediatric medicines research: lessons from the EU programme to fund research into off-patent medicines

The European Paediatric Regulation mandated the European Commission to fund research on off-patent medicines with demonstrated therapeutic interest for children. Responding to this mandate, five FP7 project calls were launched and 20 projects were granted. This paper aims to detail the funded projects and their preliminary results. Publicly available sources have been consulted and a descriptive analysis has been performed. Twenty Research Consortia including 246 partners in 29 European and non-European countries were created (involving 129 universities or public funded research organisations, 51 private companies with 40 SMEs, 7 patient associations). The funded projects investigate 24 medicines, covering 10 therapeutic areas in all paediatric age groups. In response to the Paediatric Regulation and to apply for a Paediatric Use Marketing Authorisation, 15 Paediatric Investigation Plans have been granted by the EMAPaediatric Committee, including 71 studies of whom 29 paediatric clinical trials, leading to a total of 7,300 children to be recruited in more than 380 investigational centres. Conclusion: Notwithstanding the EU contribution for each study is lower than similar publicly funded projects, and also considering the complexity of paediatric research, these projects are performing high-quality research and are progressing towards the increase of new paediatric medicines on the market. Private–public partnerships have been effectively implemented, providing a good example for future collaborative actions. Since these projects cover a limited number of offpatent drugs and many unmet therapeutic needs in paediatrics remain, it is crucial foreseeing new similar initiatives in forthcoming European funding programmes

Relevance of a photo-Fenton like technology based on peroxymonosulphate for 17b-estradiol removal from wastewater

The objective of this work was to evaluate the effectiveness of sulphate radical based homogeneous advanced oxidation technologies (SR-AOTs) involving peroxymonosulphate (PMS) as an oxidant and ferrous iron (Fe(II)) as a catalyst, for the removal of 17b-estradiol (E2) from wastewater effluents collected downstream of a biological WWTP in Perpignan (France). This molecule is used as a surrogate for endocrine disrupting compounds (EDCs) due to its high biological activity at very low concentration levels (ng/ L). For this purpose, two different laboratory-scale devices have been employed, one for indoor experiments working with controlled and artificial UV light centered on k = 365 nm emission, and the other at a larger scale for outdoor experiments using direct solar irradiation. Comparison of kinetic studies with those obtained with commonly used hydroxyl radical based advanced oxidation technologies (HR-AOTs), i.e., UV–Vis/H2O2/Fe(II) and UV/TiO2 revealed the higher efficiency of the former over the latter ones. Estrogenicity measurement through bioassays confirmed the complete removal of 17b-estradiol after only a few minutes treatment. Determination of E2 transformation pathways upon sulphate radical reactivity through intermediates identification by mass spectrometry revealed that the oxidation of phenol moiety into quinone might be the main step responsible for the decrease in estrogenicity. UV–Vis/PMS/Fe(II) system appears to be the most suitable method for the treatment of aqueous solutions containing E2

Influence of Co layer thickness on the structural and magnetic properties of multilayers

International audienceThe correlated effects of the insertion of a Pt spacer between ferromagnetic and antiferromagnetic layers and of the variation of the Co layers thickness on the structural and magnetic properties of [ (Pt/Co tCo) 3 /Pt tPt /IrMn ] n multilayers have been studied. Samples with n = 1 and 7, t Co = 0.4 and 0.6 nm, t Pt = 0 and 0.4 nm have been investigated by tomographic atom probe and superconducting quantum interference device magnetometry. For spacer free samples (t Pt = 0), the structural investigation shows that when t Co = 0.4 nm, Mn and Ir atoms diffuse deeply in the (Pt/Co) multilayers. In contrast for t Co = 0.6 nm, the Mn and Ir diffusion is much reduced. Because Pt acts as a barrier against the Mn and Ir diffusion, this difference is less pronounced in samples with Pt insertion. The hysteresis loops shapes, the exchange bias fields and the saturation magnetization values were correlated with the structural properties of these samples and discussed, taking into account the susceptibility, exchange stiffness, and perpendicular magnetic anisotropy