On the Unruh effect in de Sitter space

We give an interpretation of the temperature in de Sitter universe in terms of a dynamical Unruh effect associated with the Hubble sphere. As with the quantum noise perceived by a uniformly accelerated observer in static space-times, observers endowed with a proper motion can in principle detect the effect. In particular, we study a "Kodama observer" as a two-field Unruh detector for which we show the effect is approximately thermal. We also estimate the back-reaction of the emitted radiation and find trajectories associated with the Kodama vector fields are stable.Comment: 8 pages; corrected typos; sections structure revise

African trypanosomiasis in travelers returning to the United Kingdom.

Two returning safari tourists with African trypanosomiasis were admitted to the Hospital for Tropical Diseases, London, in a 3-day period, compared with six cases in the previous 14 years. We describe the clinical features, diagnosis, and problems encountered in accessing appropriate therapy, and discuss the potential for emergence of this disease in increasingly adventurous international travelers

A Reflective Analysis of Image Processing Operations on Kato-Katz Images for the Pathological Diagnosis of Neglected Tropical Diseases

This paper gives an insight into the interdisciplinary work that has been carried out to diagnose some of the neglected tropical diseases, in particular micro-parasitic diseases, using image processing operations. The infections from micro-parasites are collectively called Helminthiasis. The Kato-Katz method is a slide scanning technique commonly used for the qualitative and semi-quantitative diagnosis of helminthiasis. This paper explains the image analysis and processing of Kato-katz images to extract meaningful information and convert the qualitative features of the images to quantitative data and thereby effectively diagnose the disease. This is the preliminary stage of a pioneering work done in the field of neglected tropical disease diagnosis and would be beneficial for thousands of people including children in the endemic region

Temperature and pressure gas geoindicators at the Solfatara fumaroles (Campi Flegrei)

Long time series of fluid pressure and temperature within a hydrothermal system feeding the Solfatara fumaroles are investigated here, on the basis of the chemical equilibria within the CO2-H2O-H2-CO gas system. The Pisciarelli fumarole external to Solfatara crater shows an annual cycle of CO contents that indicates the occurrence of shallow secondary processes that mask the deep signals. In contrast, the Bocca Grande and Bocca Nova fumaroles located inside Solfatara crater do not show evidence of secondary processes, and their compositional variations are linked to the temperature–pressure changes within the hydrothermal system. The agreement between geochemical signals and the ground movements of the area (bradyseismic phenomena) suggests a direct relationship between the pressurization process and the ground uplift. Since 2007, the gas geoindicators have indicated pressurization of the system, which is most probably caused by the arrival of deep gases with high CO2 contents in the shallow parts of the hydrothermal system. This pressurization process causes critical conditions in the hydrothermal system, as highlighted by the increase in the fumarole temperature, the opening of new vents, and the localized seismic activity. If the pressurization process continues with time, it is not possible to rule out the occurrence of phreatic explosions

Single Event Effects in the Pixel readout chip for BTeV

In future experiments the readout electronics for pixel detectors is required to be resistant to a very high radiation level. In this paper we report on irradiation tests performed on several preFPIX2 prototype pixel readout chips for the BTeV experiment exposed to a 200 MeV proton beam. The prototype chips have been implemented in commercial 0.25 um CMOS processes following radiation tolerant design rules. The results show that this ASIC design tolerates a large total radiation dose, and that radiation induced Single Event Effects occur at a manageable level.Comment: 15 pages, 6 Postscript figure

Soil CO2 emissions at Furnas volcano (São Miguel Island, Azores archipelago) - volcano monitoring perspectives, geomorphologic studies and land-use planning application

Carbon dioxide (CO2) diffuse degassing structures (DDS) at Furnas Volcano (São Miguel Island, Azores) are mostly associated with the main fumarolic fields, evidence that CO2 soil degassing is the surface expression of rising steam from the hydrothermal system. Locations with anomalous CO2 flux are mainly controlled by tectonic structures oriented WNW-ESE and NW-SE and by the geomorphology of the volcano, as evidenced by several DDS located in depressed areas associated with crater margins. Hydrothermal soil CO2 emissions in Furnas volcano are estimated to be ~ 968 t d-1. Discrimination between biogenic and hydrothermal CO2 was determined using a 1 statistical approach and the carbon isotope composition of the CO2 efflux. Different sampling densities were used to evaluate uncertainty in the estimation of the total CO2 flux, and showed that a low density of points may not be adequate to quantify soil emanations from a relatively small DDS. Thermal energy release associated to diffuse degassing at Furnas caldera is about 118 MW (from an area of ~ 4.8 km2) based on the H2O/CO2 ratio in fumarolic gas. The DDS affect also Furnas and Ribeira Quente villages, which are located inside the caldera and in the south flank of the volcano, respectively. At these sites, 58% and 98% of the houses are built over hydrothermal CO2 emanations, and the populations are at risk due to potential high concentrations of CO2 accumulating inside the dwellings. Keywords: Soil diffuse degassing; soil CO2 flux; emission rates; Azores archipelago

Improving monitoring techniques by exploiting TerraSAR-X data: an application to Campi Flegrei (Naples, Italy)

Geodetic monitoring of the Neapolitan Volcanic District, including the Campi Flegrei caldera on the west of the city of Naples (Italy), is carried out via an integration between ground based networks and space-borne DInSAR techniques, exploiting the SAR sensors onboard ERS1-2 and ENVISAT satellites. This allowed, for instance, to follow the time evolution of the small uplift events which took place in 2000 and 2005-2006. Unfortunately, the use of the ENVISAT C-band could result sometimes in no information when dealing with very low deformation rates, as in the 2005-2006 case, when only continuous ground stations were able to detect the very beginning of the uplift event. To overcome this problem, from December 2009 we decided to use an high resolution SAR sensor operating in the X band, i.e. TerraSAR-X from DLR. TerraSAR-X High Resolution Spotlight scenes covering the main part of the Campi Flegrei caldera and centred on the Solfatara crater were used for a DInSAR analysis, using the GENESIS DLR’s software. The first two scenes (Dec. 15 and 26) were acquired with a temporal baseline of only one repetition cycle (11 days) and formed an interferogram with a very small perpendicular baseline (16.5 m). Apart from some minor atmospheric effects, the interferogram shows a small but clear deformation signal in the Pisciarelli area, close to the east side of the Solfatara crater. The ellipse shaped uplift area extends approximately 30 meters in E-W and 20 meters in N-S directions and the maximum deformation is up to 10 mm in the centre of the uplifted area. The availability of a new scene (06/01/2010) allowed three possible combinations. The deformation event highlighted by this analysis is consistent with geochemical observations carried out in Pisciarelli by INGV-OV. Pisciarelli area is seat of a fumarolic field systematically monitored in the frame of the volcanic surveillance of the Campi Flegrei caldera. Two field surveys highlighted that, during the period of SAR images acquisition, a new and strong fumarolic vent appeared in the centre of the uplifted area. In fact the vent, firstly observed on Dec. 21, was absent on Dec. 16. The two independent observations, field surveys and SAR data, suggest that the opening of the fumarolic vent was preceded by the pressurization of a small part of the fumarolic field highlighted by the documented uplift. The correlation between the dynamics of the fumarolic field and the deformation signal is confirmed by the fact that in the 26/12/2009-06/01/2010 interferogram the deformation signal is no more detectable. Finally, this case proves the high potentiality of TerraSAR-X High Resolution Spotlight data in monitoring volcanic activity with a resolution suitable for detecting also minor, but possibly dangerous, changes of the systems, as it could be in the early recognition of the signals generated by impending phreatic eruptions. TerraSAR-X High Resolution Spotlight acquisitions will continue every cycle and PS-InSAR and SBAS algorithms will be applied to carefully monitor any further changes in the activity of the Campi Flegrei volcanic system

Long time-series of chemical and isotopic compositions of Vesuvius fumaroles: evidence for deep and shallow processes

Long time-series of chemical and isotopic compositions of Vesuvius fumaroles were acquired in the framework of the volcanic surveillance in the 1998-2010 period. These allow the identification of processes that occur at shallow levels in the hydrothermal system, and variations that are induced by deep changes in volcanic activity. Partial condensation processes of fumarolic water under near-discharge conditions can explain the annual 18O and deuterium variabilities that are observed at Vesuvius fumaroles. Significant variations in the chemical compositions of fumaroles occurred over the 1999-2002 period, which accompanied the seismic crisis of autumn 1999, when Vesuvius was affected by the most energetic earthquakes of its last quiescence period. A continuous increase in the relative concentrations of CO2 and He and a general decrease in the CH4 concentrations are interpreted as the consequence of an increment in the relative amount of magmatic fluids in the hydrothermal system. Gas equilibria support this hypothesis, showing a PCO2 peak that culminated in 2002, increasing from values of ~40 bar in 1998 to ~55-60 bar in 2001- 2002. We propose that the seismic crisis of 1999 marked the arrival of the magmatic fluids into the hydrothermal system, which caused the observed geochemical variations that started in 1999 and culminated in 2002

Parallelizable Microfluidic Resistive On-Line Detector of Micrometric Aggregates of Biopharmaceutical Antibodies

A microfluidic device based on the differential measurement of the ionic resistance of a micropore for detection of aggregates of antibodies in biopharmaceutical downstream process is presented. The main novelty of this contribution regards the experimental demonstration that, despite the poor solidness of proteins, their aggregates, in their standard production buffer, can be electrically detected down to 2.4 μm diameter with sub-ms transit time (flow rate of 5 μl/min). Thanks to the simple PDMS fluidic fabrication, compact DC readout circuit and convenient use of the same metallic silver tubing for both electrical and fluidic interconnection, the device can be straightforwardly parallelized in tens of units, thus combining single micrometric sensitivity with larger flow rates (>100 μl/min), suitable for in-line installation in pharmaceutical plants