217 research outputs found
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Papillary muscle infarction in relation to left ventricular infarct distribution and transmurality - assessment by delayed enhancement cardiac magnetic resonance imaging
This study used delayed enhancement CMR (DE-CMR) and invasive angiography to evaluate relationships between papillary muscle and left ventricular (LV) chamber wall infarction following ST segment elevation MI (STEMI). Results demonstrate that papillary muscle infarction (PMI) parallels infarct transmurality and contractile dysfunction within the adjacent LV wall
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Heterogeneous Agglomeration
Many prior treatments of agglomeration explicitly or implicitly assume that all industries agglomerate for the same reasons. This paper uses U.K. establishment-level coagglomeration data to document substantial heterogeneity across industries in the microfoundations of agglomeration economies. It finds robust evidence of organizational and adaptive agglomeration forces as discussed by Chinitz (1961), Vernon (1960), and Jacobs (1969). These forces interact with the traditional Marshallian (1890) factors of input sharing, labor pooling, and knowledge spillovers, establishing a previously unrecognized complementarity between the approaches of Marshall and Jacobs, as well as others, to the analysis of agglomeration
The Effect of Chloroquine, Hydroxychloroquine and Azithromycin on the Corrected QT Interval in Patients with SARS-CoV-2 Infection
Background - The novel SARs-CoV-2 coronavirus is responsible for the global COVID-19 pandemic. Small studies have shown a potential benefit of chloroquine/hydroxychloroquine ± azithromycin for the treatment of COVID-19. Use of these medications alone, or in combination, can lead to a prolongation of the QT interval, possibly increasing the risk of Torsade de pointes (TdP) and sudden cardiac death. Methods - Hospitalized patients treated with chloroquine/hydroxychloroquine ± azithromycin from March 1st through the 23rd at three hospitals within the Northwell Health system were included in this prospective, observational study. Serial assessments of the QT interval were performed. The primary outcome was QT prolongation resulting in TdP. Secondary outcomes included QT prolongation, the need to prematurely discontinue any of the medications due to QT prolongation and arrhythmogenic death. Results - Two hundred one patients were treated for COVID-19 with chloroquine/hydroxychloroquine. Ten patients (5.0%) received chloroquine, 191 (95.0%) received hydroxychloroquine and 119 (59.2%) also received azithromycin. The primary outcome of TdP was not observed in the entire population. Baseline QTc intervals did not differ between patients treated with chloroquine/hydroxychloroquine (monotherapy group) vs. those treated with combination group (chloroquine/hydroxychloroquine and azithromycin) (440.6 ± 24.9 ms vs. 439.9 ± 24.7 ms, p =0.834). The maximum QTc during treatment was significantly longer in the combination group vs the monotherapy group (470.4 ± 45.0 ms vs. 453.3 ± 37.0 ms, p = 0.004). Seven patients (3.5%) required discontinuation of these medications due to QTc prolongation. No arrhythmogenic deaths were reported. Conclusions - In the largest reported cohort of COVID-19 patients to date treated with chloroquine/hydroxychloroquine {plus minus} azithromycin, no instances of TdP or arrhythmogenic death were reported. Although use of these medications resulted in QT prolongation, clinicians seldomly needed to discontinue therapy. Further study of the need for QT interval monitoring is needed before final recommendations can be made
Quaiselastic scattering from relativistic bound nucleons: Transverse-Longitudinal response
Predictions for electron induced proton knockout from the and
shells in O are presented using various approximations for the
relativistic nucleonic current. Results for the differential cross section,
transverse-longitudinal response () and left-right asymmetry
are compared at (GeV/c) corresponding to TJNAF experiment
89-003. We show that there are important dynamical and kinematical relativistic
effects which can be tested by experiment.Comment: 10 pages, including 2 figures. Removed preliminary experimental data
from the figure
Analysis of Meson Exchange and Isobar Currents in (e,e'p) Reactions from O-16
An analysis of the effects of meson exchange and isobar currents in exclusive
(e,e'p) processes from O-16 under quasi-free kinematics is presented. A model
that has probed its feasibility for inclusive quasi-elastic (e,e') processes is
considered. Sensitivity to final state interactions between the outgoing proton
and the residual nucleus is discussed by comparing the results obtained with
phenomenological optical potentials and a continuum nuclear shell-model
calculation. The contribution of the meson-exchange and isobar currents to the
response functions is evaluated and compared to previous calculations, which
differ notably from our results. These two-body contributions cannot solve the
puzzle of the simultaneous description of the different responses
experimentally separated. Copyright 1999 by The American Physical SocietyComment: 5 pages, plus 3 PS figures. To be published in Phys. Rev. C Updated
figure
Relativistic mean field approximation to the analysis of 16O(e,e'p)15N data at |Q^2|\leq 0.4 (GeV/c)^2
We use the relativistic distorted wave impulse approximation to analyze data
on 16O(e,e'p)15N at |Q^2|\leq 0.4 (GeV/c)^2 that were obtained by different
groups and seemed controversial. Results for differential cross-sections,
response functions and A_TL asymmetry are discussed and compared to different
sets of experimental data for proton knockout from p_{1/2} and p_{3/2} shells
in 16O. We compare with a nonrelativistic approach to better identify
relativistic effects. The present relativistic approach is found to accommodate
most of the discrepancy between data from different groups, smoothing a long
standing controversy.Comment: 28 pages, 7 figures (eps). Major revision made. New figures added. To
be published in Phys. Rev.
Willingness to pay for multifunctional megaprojects: A stated preference analysis among firms in the Amsterdam Zuidas area
http://hdl.handle.net/1871/1621
Alternative Strategies for Coping with Traffic Congestion
Traffic congestion is a disruptive fact of urban life. It inflicts delays and frustrations in virtually all major cities in the world, new or old, rich or poor. Although many countermeasures have been tried, it is hard to name a city in which there is much satisfaction with the existing state of affairs. About the only positive aspect of congestion is that it reflects the pulse of life, a demand for travel and trade that typically accompanies economic activity
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