Analyzing Two Key Points of the Huaihai Campaign Using Sun Tzu\u27s Net Assessment

This thesis focuses on the Huaihai Campaign (Nov. 6 1948 - Jan.10 1949) in the Chinese Civil War (1927-1936, 1949-1950). This war involved the Republic of China’s (ROC) Kuomintang Party (KMT) and the emerging Communist Party of China (CPC). Over the course of a few months and around one million combatants, the Communists pulled off a resounding victory dealing the final blow to the KMT which led to the CPC’s governance over mainland China. This case study of two key turning points in the Huaihai Campaign is analyzed using Sun Tzu’s five net assessments from The Art of War. Although the KMT appeared the much superior force on paper, they were dealt a decisive blow during the Huaihai Campaign. This thesis uses Sun Tzu’s five net assessments to explain the root cause of KMT decision failings. The KMT failures stemmed from ignorance of the most basic and vital military axioms of assessing advantages and disadvantages before going into battle

The Role of Surface Tension of Upper Airway Lining Liquid and Breathing Route in Sleep Disordered Breathing

This thesis examines the relationship between surface tension in the upper airway liquid, breathing route, and sleep disordered breathing. Upper airway surface tension values were examined in both healthy subjects and in those with obstructive sleep apnoea. To determine whether the enforced oral breathing route induced sleep disordered breathing via surface tension mediated mechanisms, healthy subjects were given exogenous surfactant with enforced oral route of breathing during sleep. The relationship between uncontrolled route of breathing and surface tension was then examined in subjects with severe obstructive sleep apnoea. Finally, exogenous surfactant and normal saline were administered to subjects to determine the presence of any therapeutic effect on obstructive sleep apnoea. The studies in this thesis i) described a range of surface tensions in healthy subjects, and in those with OSA, ii) investigated the role of breathing route on upper airway surface tension and OSA severity, and iii) investigated the role of exogenous surfactant as a therapeutic agent in both oral breathing induced sleep disordered breathing (in healthy subjects) and in subjects with mild to moderate obstructive sleep apnoea

Clinical applications of next generation sequencing in cancer: From panels, to exomes, to genomes

This article will review recent impact of massively parallel next-generation sequencing (NGS) in our understanding and treatment of cancer. While whole exome sequencing (WES) remains popular and effective as a method of genetically profiling different cancers, advances in sequencing technology has enabled an increasing number of whole-genome based studies. Clinically, NGS has been used or is being developed for genetic screening, diagnostics, and clinical assessment. Though challenges remain, clinicians are in the early stages of using genetic data to make treatment decisions for cancer patients. As the integration of NGS in the study and treatment of cancer continues to mature, we believe that the field of cancer genomics will need to move towards more complete 100% genome sequencing. Current technologies and methods are largely limited to coding regions of the genome. A number of recent studies have demonstrated that mutations in non-coding regions may have direct tumorigenic effects or lead to genetic instability. Non-coding regions represent an important frontier in cancer genomics

Thoracic Society of Australia and New Zealand position statement on acute oxygen use in adults : 'swimming between the flags'

Oxygen is a life-saving therapy but, when given inappropriately, may also be hazardous. Therefore, in the acute medical setting, oxygen should only be given as treatment for hypoxaemia and requires appropriate prescription, monitoring and review. This update to the Thoracic Society of Australia and New Zealand (TSANZ) guidance on acute oxygen therapy is a brief and practical resource for all healthcare workers involved with administering oxygen therapy to adults in the acute medical setting. It does not apply to intubated or paediatric patients. Recommendations are made in the following six clinical areas: assessment of hypoxaemia (including use of arterial blood gases); prescription of oxygen; peripheral oxygen saturation targets; delivery, including non-invasive ventilation and humidified high-flow nasal cannulae; the significance of high oxygen requirements; and acute hypercapnic respiratory failure. There are three sections which provide (1) a brief summary, (2) recommendations in detail with practice points and (3) a detailed explanation of the reasoning and evidence behind the recommendations. It is anticipated that these recommendations will be disseminated widely in structured programmes across Australia and New Zealand

The importance of Au⋯π(aryl) interactions in the formation of spherical aggregates in binuclear phosphane gold(I) complexes of a bipodal thiocarbamate dianion: a combined crystallographic and computational study, and anti-microbial activity

Binuclear phosphane gold(I) complexes of a bipodal thiocarbamate dianion, (R3PAu)2L, R = Et (1), Ph (2) and Cy (3), where LH2 is {1,4-[MeOC([double bond, length as m-dash]S)N(H)]2C6H4}, have been synthesised, and characterised spectroscopically (NMR and IR) and by X-ray crystallography. The gold atoms are linearly coordinated within a P-,S-donor set, and are oriented toward the central ring to form intramolecular Au⋯π(aryl) interactions, rather than the intramolecular Au⋯O interactions normally observed in mononuclear analogues. This phenomenon has been investigated by theory (LC-ωPBE-XDM) for 1 which revealed that the geometry optimised species with two Au⋯π(aryl) interactions is more stable by at least 12 kcal mol−1 compared to conformations having one or more Au⋯O interactions instead. The disk diffusion, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) methods were used to observe the inhibitory effect of complexes 1–3. The disk diffusion results demonstrated that 1 exhibited a broad spectrum of anti-bacterial activity toward 24 strains of Gram-positive and Gram-negative bacteria. By contrast, the anti-bacterial activity of 2 and 3 was limited to Gram-positive bacteria. Further evaluation showed that 1 exhibited marked bactericidal activity against B. cereus, B. subtilis, E. faecalis, L. monocytogenes, S. aureus, S. saprophyticus and methicillin resistant S. aureus cf. standard antibiotics tetracycline and chloramphenicol

Carrier Screening for Spinal Muscular Atrophy (SMA) in 107,611 Pregnant Women during the Period 2005–2009: A Prospective Population-Based Cohort Study

BACKGROUND: Spinal muscular atrophy (SMA) is the most common neuromuscular autosomal recessive disorder. The American College of Medical Genetics has recently recommended routine carrier screening for SMA because of the high carrier frequency (1 in 25-50) as well as the severity of that genetic disease. Large studies are needed to determine the feasibility, benefits, and costs of such a program. METHODS AND FINDINGS: This is a prospective population-based cohort study of 107,611 pregnant women from 25 counties in Taiwan conducted during the period January 2005 to June 2009. A three-stage screening program was used: (1) pregnant women were tested for SMA heterozygosity; (2) if the mother was determined to be heterozygous for SMA (carrier status), the paternal partner was then tested; (3) if both partners were SMA carriers, prenatal diagnostic testing was performed. During the study period, a total of 2,262 SMA carriers with one copy of the SMN1 gene were identified among the 107,611 pregnant women that were screened. The carrier rate was approximately 1 in 48 (2.10%). The negative predictive value of DHPLC coupled with MLPA was 99.87%. The combined method could detect approximately 94% of carriers because most of the cases resulted from a common single deletion event. In addition, 2,038 spouses were determined to be SMA carriers. Among those individuals, 47 couples were determined to be at high risk for having offspring with SMA. Prenatal diagnostic testing was performed in 43 pregnant women (91.49%) and SMA was diagnosed in 12 (27.91%) fetuses. The prevalence of SMA in our population was 1 in 8,968. CONCLUSION: The main benefit of SMA carrier screening is to reduce the burden associated with giving birth to an affected child. In this study, we determined the carrier frequency and genetic risk and provided carrier couples with genetic services, knowledge, and genetic counseling

Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels

Large-scale meta-analyses of genome-wide association studies (GWAS) have identified >175 loci associated with fasting cholesterol levels, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). With differences in linkage disequilibrium (LD) structure and allele frequencies between ancestry groups, studies in additional large samples may detect new associations. We conducted staged GWAS meta-analyses in up to 69,414 East Asian individuals from 24 studies with participants from Japan, the Philippines, Korea, China, Singapore, and Taiwan. These meta-analyses identified (P < 5 × 10-8) three novel loci associated with HDL-C near CD163-APOBEC1 (P = 7.4 × 10-9), NCOA2 (P = 1.6 × 10-8), and NID2-PTGDR (P = 4.2 × 10-8), and one novel locus associated with TG near WDR11-FGFR2 (P = 2.7 × 10-10). Conditional analyses identified a second signal near CD163-APOBEC1. We then combined results from the East Asian meta-analysis with association results from up to 187,365 European individuals from the Global Lipids Genetics Consortium in a trans-ancestry meta-analysis. This analysis identified (log10Bayes Factor ≥6.1) eight additional novel lipid loci. Among the twelve total loci identified, the index variants at eight loci have demonstrated at least nominal significance with other metabolic traits in prior studies, and two loci exhibited coincident eQTLs (P < 1 × 10-5) in subcutaneous adipose tissue for BPTF and PDGFC. Taken together, these analyses identified multiple novel lipid loci, providing new potential therapeutic targets

How Mutual Fund Manager Professional Networks Affect Investor Welfare

This dissertation analyzes the link between the professional networks of mutual fund managers and its effect on fund investor welfare. A unique dataset is constructed for analysis based on third-party verified U.S. corporate board ties. Chapter 1 first examines whether U.S. mutual funds associated with fund managers possessing board connections (“connected” fund managers) have an advantage over mutual funds that are not associated with “connected” fund managers. The evidence I find suggests mutual funds associated with “connected” fund managers outperform their “non-connected” counterparts by an average of 1.57% in annual returns. Additionally, mutual funds with “connected” fund managers collect higher fees. Overall, the findings suggest “connected” mutual funds send higher returns to fund investors while keeping some for themselves in the form of fees. Having established board connections matter on a fund level, in Chapter 2 the focus shifts from the fund level to the fund manager level by studying the “connected” fund managers’ positioning within a social network hierarchy using the theory of network centrality. In other words, this chapter examines whether the professional networks of mutual fund managers, in the context of board director relationships, offer a mechanism of information flows to fund managers that ultimately affect fund investor welfare. The evidence points to fund managers enjoying higher returns when they are well-connected (via direct connections), and when their immediate connections are well-connected (via indirect connections). A long-short portfolio strategy based on eigenvector, a network centrality variable measuring how connected the fund managers’ immediate connections are (network quality), yields positive and statistically significant mean and risk-adjusted returns for both in-sample and out-of-sample testing. The results suggest fund managers use their director networks as conduits for obtaining relevant information, where the opportunity for obtaining relevant information increases as the quality of the fund managers’ professional network increases. Additional evidence also suggests fund managers may be holding back on utilizing the information from their current board appointment relationships