Heliospheric plasma sheets

[1] As a high-beta feature on scales of hours or less, the heliospheric plasma sheet (HPS) encasing the heliospheric current sheet shows a high degree of variability. A study of 52 sector boundaries identified in electron pitch angle spectrograms in Wind data from 1995 reveals that only half concur with both high-beta plasma and current sheets, as required for an HPS. The remaining half lack either a plasma sheet or current sheet or both. A complementary study of 37 high-beta events reveals that only 5 contain sector boundaries while nearly all (34) contain local magnetic field reversals, however brief. We conclude that high-beta plasma sheets surround current sheets but that most of these current sheets are associated with fields turned back on themselves. The findings are consistent with the hypothesis that high-beta plasma sheets, both at and away from sector boundaries, are the heliospheric counterparts of the small coronal transients observed at the tips of helmet streamers, in which case the proposed mechanism for their release, interchange reconnection, could be responsible for the field inversions

The Design of the Monitoring System for the Thermal Effect of the Surry Nuclear Power Plant on the James River

The demand for electric power in the United States is expected to double every 10 years. As hydroelectric power plant sites reach their full capacity, the demand for electricity will be met by the development of fossil fuel and nuclear power plants. The average thermal efficiency of nuclear power plants is presently about 32%. Therefore, a significant amount of heat is not utilized. For large power plants, the once-through cooling method, in which water is withdrawn from an adjacent body of water and returned after being heated, is the most common one. However, the great amount of heat discharged into the water may result in changes in the physical and chemical properties as well as in the ecology due to the rise in temperature of the water. The objectives of this study is to determine the region of the James River estuary which will be affected by the thermal discharges of the Surry nuclear power plant located at Hog Island and the temperature distribution within that region. The area under study is shown in figure 1. The cooling water is pumped in from the James River at the right side of Hog Island and returned at the left side. The following is a progress report of the first year\u27s work on this project

Storm‐time configuration of the inner magnetosphere: Lyon‐Fedder‐Mobarry MHD code, Tsyganenko model, and GOES observations

[1] We compare global magnetohydrodynamic (MHD) simulation results with an empirical model and observations to understand the magnetic field configuration and plasma distribution in the inner magnetosphere, especially during geomagnetic storms. The physics-based Lyon-Fedder-Mobarry (LFM) code simulates Earth\u27s magnetospheric topology and dynamics by solving the equations of ideal MHD. Quantitative comparisons of simulated events with observations reveal strengths and possible limitations and suggest ways to improve the LFM code. Here we present a case study that compares the LFM code to both a semiempirical magnetic field model and to geosynchronous measurements from GOES satellites. During a magnetic cloud event, the simulation and model predictions compare well qualitatively with observations, except during storm main phase. Quantitative statistical studies of the MHD simulation shows that MHD field lines are consistently under-stretched, especially during storm time (Dst \u3c −20 nT) on the nightside, a likely consequence of an insufficient representation of the inner magnetosphere current systems in ideal MHD. We discuss two approaches for improving the LFM result: increasing the simulation spatial resolution and coupling LFM with a ring current model based on drift physics (i.e., the Rice Convection Model (RCM)). We show that a higher spatial resolution LFM code better predicts geosynchronous magnetic fields (not only the average Bz component but also higher-frequency fluctuations driven by the solar wind). An early version of the LFM/RCM coupled code, which runs so far only for idealized events, yields a much-improved ring current, quantifiable by decreased field strengths at all local times compared to the LFM-only code

Predicting magnetopause crossings at geosynchronous orbit during the Halloween storms

[1] In late October and early November of 2003, the Sun unleashed a powerful series of events known as the Halloween storms. The coronal mass ejections launched by the Sun produced several severe compressions of the magnetosphere that moved the magnetopause inside of geosynchronous orbit. Such events are of interest to satellite operators, and the ability to predict magnetopause crossings along a given orbit is an important space weather capability. In this paper we compare geosynchronous observations of magnetopause crossings during the Halloween storms to crossings determined from the Lyon-Fedder-Mobarry global magnetohydrodynamic simulation of the magnetosphere as well to predictions of several empirical models of the magnetopause position. We calculate basic statistical information about the predictions as well as several standard skill scores. We find that the current Lyon-Fedder-Mobarry simulation of the storm provides a slightly better prediction of the magnetopause position than the empirical models we examined for the extreme conditions present in this study. While this is not surprising, given that conditions during the Halloween storms were well outside the parameter space of the empirical models, it does point out the need for physics-based models that can predict the effects of the most extreme events that are of significant interest to users of space weather forecasts

Lambda-prophage induction modeled as a cooperative failure mode of lytic repression

We analyze a system-level model for lytic repression of lambda-phage in E. coli using reliability theory, showing that the repressor circuit comprises 4 redundant components whose failure mode is prophage induction. Our model reflects the specific biochemical mechanisms involved in regulation, including long-range cooperative binding, and its detailed predictions for prophage induction in E. coli under ultra-violet radiation are in good agreement with experimental data.Comment: added referenc

Efficient, designable, and broad-bandwidth optical extinction via aspect-ratio-tailored silver nanodisks

Subwavelength resonators, ranging from single atoms to metallic nanoparticles, typically exhibit a narrow-bandwidth response to optical excitations. We computationally design and experimentally synthesize tailored distributions of silver nanodisks to extinguish light over broad and varied frequency windows. We show that metallic nanodisks are two-to-ten-times more efficient in absorbing and scattering light than common structures, and can approach fundamental limits to broadband scattering for subwavelength particles. We measure broadband extinction per volume that closely approaches theoretical predictions over three representative visible-range wavelength windows, confirming the high efficiency of nanodisks and demonstrating the collective power of computational design and experimental precision for developing new photonics technologies

Observation of the spontaneous vortex phase in the weakly ferromagnetic superconductor ErNi2_{2}B2_{2}C: A penetration depth study

The coexistence of weak ferromagnetism and superconductivity in ErNi$_{2}$B$_{2}$C suggests the possibility of a spontaneous vortex phase (SVP) in which vortices appear in the absence of an external field. We report evidence for the long-sought SVP from the in-plane magnetic penetration depth $\Delta \lambda (T)$ of high-quality single crystals of ErNi$_{2}$B$_{2}$C. In addition to expected features at the N\'{e}el temperature $T_{N}$ = 6.0 K and weak ferromagnetic onset at $T_{WFM}=2.3$K, $\Delta \lambda (T)$ rises to a maximum at $T_{m}=0.45$ K before dropping sharply down to $\sim$0.1 K. We assign the 0.45 K-maximum to the proliferation and freezing of spontaneous vortices. A model proposed by Koshelev and Vinokur explains the increasing $\Delta \lambda (T)$ as a consequence of increasing vortex density, and its subsequent decrease below $T_{m}$ as defect pinning suppresses vortex hopping.Comment: 5 pages including figures; added inset to Figure 2; significant revisions to tex

CDKN1C/p57kip2 Is a Candidate Tumor Suppressor Gene in Human Breast Cancer

BACKGROUND. CDKN1C (also known as p57KIP2) is a cyclin-dependent kinase inhibitor previously implicated in several types of human cancer. Its family members (CDKN1A/p21CIP1 and B/p27KIP1) have been implicated in breast cancer, but information about CDKN1C's role is limited. We hypothesized that decreased CDKN1C may be involved in human breast carcinogenesis in vivo. METHODS. We determined rates of allele imbalance or loss of heterozygosity (AI/LOH) in CDKN1C, using an intronic polymorphism, and in the surrounding 11p15.5 region in 82 breast cancers. We examined the CDKN1C mRNA level in 10 cancers using quantitative real-time PCR (qPCR), and the CDKN1C protein level in 20 cancers using immunohistochemistry (IHC). All samples were obtained using laser microdissection. Data were analyzed using standard statistical tests. RESULTS. AI/LOH at 11p15.5 occurred in 28/73 (38%) informative cancers, but CDKN1C itself underwent AI/LOH in only 3/16 (19%) cancers (p = ns). In contrast, CDKN1C mRNA levels were reduced in 9/10 (90%) cancers (p < 0.0001), ranging from 2–60% of paired normal epithelium. Similarly, CDKN1C protein staining was seen in 19/20 (95%) cases' normal epithelium but in only 7/14 (50%) cases' CIS (p < 0.004) and 5/18 (28%) cases' IC (p < 0.00003). The reduction appears primarily due to loss of CDKN1C expression from myoepithelial layer cells, which stained intensely in 17/20 (85%) normal lobules, but in 0/14 (0%) CIS (p < 0.00001). In contrast, luminal cells displayed less intense, focal staining fairly consistently across histologies. Decreased CDKN1C was not clearly associated with tumor grade, histology, ER, PR or HER2 status. CONCLUSION. CDKN1C is expressed in normal epithelium of most breast cancer cases, mainly in the myothepithelial layer. This expression decreases, at both the mRNA and protein level, in the large majority of breast cancers, and does not appear to be mediated by AI/LOH at the gene. Thus, CDKN1C may be a breast cancer tumor suppressor.Department of Defense Breast Cancer Research Program (DAMD 17-99-1-9573); National Institutes of Health PHS (CA081078); LaPann Fun

Effects of multi-stage dehumidified-air drying on the polyphenol content of Hydrocotyle bonariensis

Traditional drying methods involve high temperatures that degrade heat-sensitive compounds. Dehumidified-air drying, an alternative to traditional drying methods, is suitable for heat-sensitive compounds; however, it consumes a large amount of energy and is comparatively expensive. In this study, a multi-chamber dehumidified-air dryer was designed to dry Hydrocotyle bonariensis, and the retention of the polyphenol content of Hydrocotyle bonariensis under various drying conditions was examined. Multi-chamber dehumidified-air drying involves two chambers; each chamber was operated at temperatures of 30, 40, and 50°C with air volumetric flow rates of 30 and 50 L/min. The results indicated that the highest retention of total phenolic content and total flavonoid content, 24.67 mg of GAE/g dry weight (DW) and 2.204 mg of catechin/g DW, respectively, was obtained at 50°C with a 50 L/min air flow rate in the first drying chamber. Multi-stage dehumidified-air dryers have the potential to dry heat-sensitive products with reduced energy consumption