Retroviral Protease (RVP) DDI2 is a Viable Alternative for Full-Length (FL) DDI2

Proteasome inhibitors are drugs used to treat multiple myeloma. Currently, three are approved by the FDA.https://digitalscholarship.unlv.edu/durep_lightning/1020/thumbnail.jp

Multilingual BERT, Ergativity, and Grammatical Subjecthood

We investigate how Multilingual BERT (mBERT) encodes grammar by examining how the high-order grammatical feature of morphosyntactic alignment (how different languages define what counts as a subject ) is manifested across the embedding spaces of different languages. To understand if and how morphosyntactic alignment affects contextual embedding spaces, we train classifiers to recover the subjecthood of mBERT embeddings in transitive sentences (which do not contain overt information about morphosyntactic alignment) and then evaluate them zero-shot on intransitive sentences (where subjecthood classification depends on alignment), within and across languages. We find that the resulting classifier distributions reflect the morphosyntactic alignment of their training languages. Our results demonstrate that mBERT representations are influenced by high-level grammatical features that are not manifested in any one input sentence, and that this is robust across languages. Further examining the characteristics that our classifiers rely on, we find that features such as passive voice, animacy and case strongly correlate with classification decisions, suggesting that mBERT does not encode a purely syntactic subjecthood, but a continuous subjecthood as is proposed in much of the functional linguistics literature. Together, these results provide insight into how grammatical features manifest in contextual embedding spaces, at a level of abstraction not covered by previous work

Moving Domain Computational Fluid Dynamics to Interface with an Embryonic Model of Cardiac Morphogenesis

Peristaltic contraction of the embryonic heart tube produces time- and spatial-varying wall shear stress (WSS) and pressure gradients (∇P) across the atrioventricular (AV) canal. Zebrafish (Danio rerio) are a genetically tractable system to investigate cardiac morphogenesis. The use of Tg(fli1a:EGFP)y1 transgenic embryos allowed for delineation and two-dimensional reconstruction of the endocardium. This time-varying wall motion was then prescribed in a two-dimensional moving domain computational fluid dynamics (CFD) model, providing new insights into spatial and temporal variations in WSS and ∇P during cardiac development. The CFD simulations were validated with particle image velocimetry (PIV) across the atrioventricular (AV) canal, revealing an increase in both velocities and heart rates, but a decrease in the duration of atrial systole from early to later stages. At 20-30 hours post fertilization (hpf), simulation results revealed bidirectional WSS across the AV canal in the heart tube in response to peristaltic motion of the wall. At 40-50 hpf, the tube structure undergoes cardiac looping, accompanied by a nearly 3-fold increase in WSS magnitude. At 110-120 hpf, distinct AV valve, atrium, ventricle, and bulbus arteriosus form, accompanied by incremental increases in both WSS magnitude and ∇P, but a decrease in bi-directional flow. Laminar flow develops across the AV canal at 20-30 hpf, and persists at 110-120 hpf. Reynolds numbers at the AV canal increase from 0.07±0.03 at 20-30 hpf to 0.23±0.07 at 110-120 hpf (p< 0.05, n=6), whereas Womersley numbers remain relatively unchanged from 0.11 to 0.13. Our moving domain simulations highlights hemodynamic changes in relation to cardiac morphogenesis; thereby, providing a 2-D quantitative approach to complement imaging analysis. © 2013 Lee et al

Associations between Statin/Omega3 Usage and MRI-Based Radiomics Signatures in Prostate Cancer

Prostate cancer is the most common noncutaneous cancer and the second leading cause of cancer deaths among American men. Statins and omega-3 are two medications recently found to correlate with prostate cancer risk and aggressiveness, but the observed associations are complex and controversial. We therefore explore the novel application of radiomics in studying statin and omega-3 usage in prostate cancer patients. On MRIs of 91 prostate cancer patients, two regions of interest (ROIs), the whole prostate and the peripheral region of the prostate, were manually segmented. From each ROI, 944 radiomic features were extracted after field bias correction and normalization. Heatmaps were generated to study the radiomic feature patterns against statin or omega-3 usage. Radiomics models were trained on selected features and evaluated with 500-round threefold cross-validation for each drug/ROI combination. On the 1500 validation datasets, the radiomics model achieved average AUCs of 0.70, 0.74, 0.78, and 0.72 for omega-3/prostate, omega- 3/peripheral, statin/prostate, and statin/peripheral, respectively. As the first study to analyze radiomics in relation to statin and omega-3 uses in prostate cancer patients, our study preliminarily established the existence of imaging-identifiable tissue-level changes in the prostate and illustrated the potential usefulness of radiomics for further exploring these medications’ effects and mechanisms in prostate cancer

Engineering Robust Metallic Zero-Mode States in Olympicene Graphene Nanoribbons

Metallic graphene nanoribbons (GNRs) represent a critical component in the toolbox of low-dimensional functional materials technolo-gy serving as 1D interconnects capable of both electronic and quantum information transport. The structural constraints imposed by on-surface bottom-up GNR synthesis protocols along with the limited control over orientation and sequence of asymmetric monomer building blocks during the radical step-growth polymerization has plagued the design and assembly of metallic GNRs. Here we report the regioregular synthesis of GNRs hosting robust metallic states by embedding a symmetric zero-mode superlattice along the backbone of a GNR. Tight-binding electronic structure models predict a strong nearest-neighbor electron hopping interaction between adjacent zero-mode states resulting in a dispersive metallic band. First principles DFT-LDA calculations confirm this prediction and the robust, metallic zero-mode band of olympicene GNRs (oGNRs) is experimentally corroborated by scanning tunneling spectroscopy.Comment: 8 pages, 4 figure

An annotated bibliography for comparative prime number theory

The goal of this annotated bibliography is to record every publication on the topic of comparative prime number theory together with a summary of its results. We use a unified system of notation for the quantities being studied and for the hypotheses under which results are obtained. We encourage feedback on this manuscript (see the end of Section~1 for details).Comment: 98 pages; supersedes "Comparative prime number theory: A survey" (arXiv:1202.3408