Tow-steered Aeroelastic Tailoring for Improved Horizontal Stabiliser Performance

Aeroelastic tailoring based on tow-steered composites is applied to the structural design of a horizontal stabiliser. The lift-curve slope of the stabiliser is viewed as the primary performance measure in this work and the aim of the aeroelastic tailoring process is to increase it, with consideration to the stabiliser in a forward, zero or backward-swept configuration. The tow-steered design is compared to a structurally stiff baseline as well as an aeroelastically tailored unidirectional design. It is shown that the use of tow-steered composites can improve the lift-curve slope in all sweep configurations, as well as resulting in designs that can distribute stresses more evenly under load. Furthermore, the tow-steered design enables an additional gain of 3.8% in lift-curve slope beyond the optimal unidirectional ply design

Experimental and Numerical Nonlinear Stability Analysis of Wings Incorporating Flared Folding Wingtips

Recent studies have considered the use of wings incorporating flared folding wingtips (FFWTs) to enable higher aspect ratios (reducing overall induced drag) while also reducing gust loading and meeting airport operational requirements. This paper presents the first experimental research into the nonlinear dynamic behavior of a wing incorporating an FFWT. Wind-tunnel tests were conducted at a range of velocities below and beyond the linear flutter boundary. The experimental findings are compared with results obtained from continuation and bifurcation analyses on a representative low-fidelity numerical model. The results show that beyond the linear flutter boundary, stable limit cycle oscillations form, which is dependent on the flare angle, are bounded by either geometric or aerodynamic nonlinearities. Also presented is the effect of a wingtip trim tab on the stability boundary of a wing incorporating FFWTs. It is found that the tab angle can significantly alter the stability boundary of the system, indicating that the choice of camber is an important parameter when considering the stability boundary of FFWTs and that a moveable control surface on an FFWT could be used “in flight” to extend the stability boundary of an aircraft

MICU1 Motifs Define Mitochondrial Calcium Uniporter Binding and Activity

SummaryResting mitochondrial matrix Ca2+ is maintained through a mitochondrial calcium uptake 1 (MICU1)-established threshold inhibition of mitochondrial calcium uniporter (MCU) activity. It is not known how MICU1 interacts with MCU to establish this Ca2+ threshold for mitochondrial Ca2+ uptake and MCU activity. Here, we show that MICU1 localizes to the mitochondrial matrix side of the inner mitochondrial membrane and MICU1/MCU binding is determined by a MICU1 N-terminal polybasic domain and two interacting coiled-coil domains of MCU. Further investigation reveals that MICU1 forms homo-oligomers, and this oligomerization is independent of the polybasic region. However, the polybasic region confers MICU1 oligomeric binding to MCU and controls mitochondrial Ca2+ current (IMCU). Moreover, MICU1 EF hands regulate MCU channel activity, but do not determine MCU binding. Loss of MICU1 promotes MCU activation leading to oxidative burden and a halt to cell migration. These studies establish a molecular mechanism for MICU1 control of MCU-mediated mitochondrial Ca2+ accumulation, and dysregulation of this mechanism probably enhances vascular dysfunction