The sensitivity to antibiotics of nosocomial strains of acinetobacter baumanii isolated in the tertiary hospitals in the Central Kazakhstan

Del 1972, en l'actual emplaçament des de 1976. D'acer pintat, mesura 5 x 3,54 x 3,20 metres.Calder, Alexander (escultor)Pla general de l'obra. La galeria Maeght va decidir instal·lar una sucursal a Barcelona i va triar fer-ho al carrer de Montcada. Va obrir amb una exposició que incloïa una peça de Calder, Quatre ales. Després fou oferida a l'Ajuntament

The Potential Electrospinnability and Filtration Capabilities of Pea- Protein Isolate/Polyvinyl Alcohol Air Filter Nanofabrics: A Systematic Review

Given the pervasiveness of air pollution with varying components and the shortcomings of conventional air filter mats, multifunctional air filters are becoming increasingly important. This has led to the development of air filter nanofabrics comprising bio-based components (such as chitin and proteins) and polymers (such as polyvinyl alcohol and pullulan). Electrospun air filter nanofabrics containing pea protein isolate (PPI) and polyvinyl alcohol (PVA) have yet to be developed to the researchers’ knowledge. In this study, the potential electrospinnability and filtration capabilities of PPI and PVA were assessed and elaborated via a systematic review. Since PPI’s globular morphology lacks molecular entanglement, PVA, an auxiliary spinning polymer with protein binding capabilities, is needed to aid PPI. Combining the two has successfully produced electrospun homogenous nanofabrics. Additionally, the nanofabrics likely possess physical and chemical filtration capabilities due to desirable material properties and powerful intermolecular interactions. Thus, PPI/PVA nanofabrics show great potential for multifunctional air filtration applications

A therapy for suppressing canonical and noncanonical SARS-CoV-2 viral entry and an intrinsic intrapulmonary inflammatory response

The prevalence of "long COVID" is just one of the conundrums highlighting how little we know about the lung's response to viral infection, particularly to syndromecoronavirus-2 (SARS-CoV-2), for which the lung is the point of entry. We used an in vitro human lung system to enable a prospective, unbiased, sequential single-cell level analysis of pulmonary cell responses to infection by multiple SARS-CoV-2 strains. Starting with human induced pluripotent stem cells and emulating lung organogenesis, we generated and infected three-dimensional, multi-cell-type-containing lung organoids (LOs) and gained several unexpected insights. First, SARS-CoV-2 tropism is much broader than previously believed: Many lung cell types are infectable, if not through a canonical receptor-mediated route (e.g., via Angiotensin-converting encyme 2(ACE2)) then via a noncanonical "backdoor" route (via macropinocytosis, a form of endocytosis). Food and Drug Administration (FDA)-approved endocytosis blockers can abrogate such entry, suggesting adjunctive therapies. Regardless of the route of entry, the virus triggers a lung-autonomous, pulmonary epithelial cell-intrinsic, innate immune response involving interferons and cytokine/chemokine production in the absence of hematopoietic derivatives. The virus can spread rapidly throughout human LOs resulting in mitochondrial apoptosis mediated by the prosurvival protein Bcl-xL. This host cytopathic response to the virus may help explain persistent inflammatory signatures in a dysfunctional pulmonary environment of long COVID. The host response to the virus is, in significant part, dependent on pulmonary Surfactant Protein-B, which plays an unanticipated role in signal transduction, viral resistance, dampening of systemic inflammatory cytokine production, and minimizing apoptosis. Exogenous surfactant, in fact, can be broadly therapeutic

Infected pancreatic necrosis: outcomes and clinical predictors of mortality. A post hoc analysis of the MANCTRA-1 international study

: The identification of high-risk patients in the early stages of infected pancreatic necrosis (IPN) is critical, because it could help the clinicians to adopt more effective management strategies. We conducted a post hoc analysis of the MANCTRA-1 international study to assess the association between clinical risk factors and mortality among adult patients with IPN. Univariable and multivariable logistic regression models were used to identify prognostic factors of mortality. We identified 247 consecutive patients with IPN hospitalised between January 2019 and December 2020. History of uncontrolled arterial hypertension (p = 0.032; 95% CI 1.135-15.882; aOR 4.245), qSOFA (p = 0.005; 95% CI 1.359-5.879; aOR 2.828), renal failure (p = 0.022; 95% CI 1.138-5.442; aOR 2.489), and haemodynamic failure (p = 0.018; 95% CI 1.184-5.978; aOR 2.661), were identified as independent predictors of mortality in IPN patients. Cholangitis (p = 0.003; 95% CI 1.598-9.930; aOR 3.983), abdominal compartment syndrome (p = 0.032; 95% CI 1.090-6.967; aOR 2.735), and gastrointestinal/intra-abdominal bleeding (p = 0.009; 95% CI 1.286-5.712; aOR 2.710) were independently associated with the risk of mortality. Upfront open surgical necrosectomy was strongly associated with the risk of mortality (p < 0.001; 95% CI 1.912-7.442; aOR 3.772), whereas endoscopic drainage of pancreatic necrosis (p = 0.018; 95% CI 0.138-0.834; aOR 0.339) and enteral nutrition (p = 0.003; 95% CI 0.143-0.716; aOR 0.320) were found as protective factors. Organ failure, acute cholangitis, and upfront open surgical necrosectomy were the most significant predictors of mortality. Our study confirmed that, even in a subgroup of particularly ill patients such as those with IPN, upfront open surgery should be avoided as much as possible. Study protocol registered in ClinicalTrials.Gov (I.D. Number NCT04747990)

The effects of infrastructure, process support, marketing assistance, and networking services provided by business incubators on startup survival during COVID-19: A case study on startup founders under DTI IDEA

Business incubators have been around for decades and their main purpose is to cultivate startups that have potential in the market with their usual service offerings being providing infrastructure, marketing assistance, process support, and networking activities. Most studies show that these services contribute to increasing the survival of startups, however, there are few studies done in the middle of the pandemic where many businesses were shut down. This study aims to address the effects of business incubator services to the survival of startups as well as the effect of each type of service on startups that were newly established during the pandemic. With this, the researchers conducted a case study on the Incubation, Development, and Entrepreneurial Assistance (IDEA) Program of DTI Idea and PhilDev Foundation with a total of 34 startup founders and co-founders under it. Through Pearson Correlation, Linear and Multiple Regression, Durbin-Watson Test and Multicollinearity Statistics, the results show that the four business incubator services, individually and collectively, significantly contribute to the startup survival. These findings bring value to most especially to managers in knowing what to prioritize in order to increase their survival