Evaluating air quality by combining stationary, smart mobile pollution monitoring and data-driven modelling

© 2019 Elsevier Ltd Air pollution impact assessment is a major objective for various community councils in large cities, which have lately redirected their attention towards using more low-cost sensing units supported by citizen involvement. However, there is a lack of research studies investigating real-time mobile air-quality measurement through smart sensing units and even more of any data-driven modelling techniques that could be deployed to predict air quality accurately from the generated data-sets. This paper addresses these challenges by: a) proposing a comparative and detailed investigation of various air quality monitoring devices (both fixed and mobile), tested through field measurements and citizen sensing in an eco-neighbourhood from Lorraine, France, and by b) proposing a machine learning approach to evaluate the accuracy and potential of such mobile generated data for air quality prediction. The air quality evaluation consists of three experimenting protocols: a) first, we installed fixed passive tubes for monitoring the nitrogen dioxide concentrations placed in strategic locations highly affected by traffic circulation in an eco-neighbourhood, b) second, we monitored the nitrogen dioxide registered by citizens using smart and mobile pollution units carried at breathing level; results revealed that mobile-captured concentrations were 3–5 times higher than the ones registered by passive-static monitoring tubes and c) third, we compared different mobile pollution stations working simultaneously, which revealed noticeable differences in terms of result variability and sensitivity. Finally, we applied a machine learning modelling by using decision trees and neural networks on the mobile-generated data and show that humidity and noise are the most important factors influencing the prediction of nitrogen dioxide concentrations of mobile stations

Pregnancy and Delivery Costs in Georgia Medicaid: PCCM Versus Fee-for-Service Enrollees

This study examines the enrollment, resource utilization, and prenatal care cost patterns among pregnant black and white women in Georgia’s PCCM program, Georgia Better Health Care (GBHC), compared with those acquiring pregnancy and delivery services through Georgia’s Fee for Service (FFS) sector. Birth certificate data from 1998 were linked with Medicaid enrollment and claims data from 1997 and 1998 to construct a retrospective pregnancy history for each Medicaid woman giving birth in Georgia hospitals in 1998. Total payments for pregnancy and delivery services and on the total number of prenatal care visits were derived for each woman in the sample. Multivariate logistic analyses were employed to assess the role of PCCM versus FFS in determining total payments and the likelihood of a prenatal hospitalization, length of hospital stay longer than 2 days following delivery, and cesarean section delivery. While prenatal pregnancy services and delivery costs were higher for those in PCCM than FFS, PCCM women had fewer prenatal care visits and were less likely to have delivery stays longer than 2 days postpartum compared with FFS women. The higher costs under PCCM are apparently related to the finding that this delivery system was highly associated with having more prenatal hospitalizations compared with FFS. In similar analyses conducted separately for white and black pregnant women, black women served by PCCM followed these overall results across delivery systems while there were no differences in the likelihood of a prenatal hospitalization or total prenatal care visits for whites served by PCCM versus FFS. In light of Georgia’s turn toward full capitation under its new managed care initiative, many issues regarding pregnancy services and delivery such as earlier program enrollment, coordination of care, payment policies and capitation rates will need to be addressed

Identification of Chromatin-Associated Regulators of MSL Complex Targeting in Drosophila Dosage Compensation

Sex chromosome dosage compensation in Drosophila provides a model for understanding how chromatin organization can modulate coordinate gene regulation. Male Drosophila increase the transcript levels of genes on the single male X approximately two-fold to equal the gene expression in females, which have two X-chromosomes. Dosage compensation is mediated by the Male-Specific Lethal (MSL) histone acetyltransferase complex. Five core components of the MSL complex were identified by genetic screens for genes that are specifically required for male viability and are dispensable for females. However, because dosage compensation must interface with the general transcriptional machinery, it is likely that identifying additional regulators that are not strictly male-specific will be key to understanding the process at a mechanistic level. Such regulators would not have been recovered from previous male-specific lethal screening strategies. Therefore, we have performed a cell culture-based, genome-wide RNAi screen to search for factors required for MSL targeting or function. Here we focus on the discovery of proteins that function to promote MSL complex recruitment to “chromatin entry sites,” which are proposed to be the initial sites of MSL targeting. We find that components of the NSL (Non-specific lethal) complex, and a previously unstudied zinc-finger protein, facilitate MSL targeting and display a striking enrichment at MSL entry sites. Identification of these factors provides new insight into how MSL complex establishes the specialized hyperactive chromatin required for dosage compensation in Drosophila

New Outlook on the Possible Existence of Superheavy Elements in Nature

A consistent interpretation is given to some previously unexplained phenomena seen in nature in terms of the recently discovered long-lived high spin super- and hyper-deformed isomeric states. The Po halos seen in mica are interpreted as due to the existence of such isomeric states in corresponding Po or nearby nuclei which eventually decay by gamma- or beta-decay to the ground states of 210Po, 214Po and 218Po nuclei. The low-energy 4.5 MeV alpha-particle group observed in several minerals is interpreted as due to a very enhanced alpha transition from the third minimum of the potential-energy surface in a superheavy nucleus with atomic number Z=108 (Hs) and atomic mass number around 271 to the corresponding minimum in the daughter.Comment: 8 pages, 8 figures, 5 tables. Paper presented at VII Int. School-Seminar on Heavy Ion Physics, May 27 - June 1, 2002, Dubna, Russi

Present-day uplift of the western Alps

International audienceCollisional mountain belts grow as a consequence of continental plate convergence and eventuallydisappear under the combined effects of gravitational collapse and erosion. Using a decade ofGPS data, we show that the western Alps are currently characterized by zero horizontal velocityboundary conditions, offering the opportunity to investigate orogen evolution at the time ofcessation of plate convergence. We find no significant horizontal motion within the belt, but GPS andlevelling measurements independently show a regional pattern of uplift reaching ~2.5 mm/yr in thenorthwestern Alps. Unless a low viscosity crustal root under the northwestern Alps locally enhancesthe vertical response to surface unloading, the summed effects of isostatic responses to erosion andglaciation explain at most 60% of the observed uplift rates. Rock-uplift rates corrected from transientglacial isostatic adjustment contributions likely exceed erosion rates in the northwestern Alps. In theabsence of active convergence, the observed surface uplift must result from deep-seated processes

GPS network monitor the Western Alps deformation over a five year period: 1993-1998

GPS surveys in the Western Alps, performed in the time span 1993-2003, estimated the current crustal deformation of this area.Published63-763.2. Tettonica attivaJCR Journalreserve

Marine bacterial, archaeal and protistan association networks reveal ecological linkages

Microbes have central roles in ocean food webs and global biogeochemical processes, yet specific ecological relationships among these taxa are largely unknown. This is in part due to the dilute, microscopic nature of the planktonic microbial community, which prevents direct observation of their interactions. Here, we use a holistic (that is, microbial system-wide) approach to investigate time-dependent variations among taxa from all three domains of life in a marine microbial community. We investigated the community composition of bacteria, archaea and protists through cultivation-independent methods, along with total bacterial and viral abundance, and physico-chemical observations. Samples and observations were collected monthly over 3 years at a well-described ocean time-series site of southern California. To find associations among these organisms, we calculated time-dependent rank correlations (that is, local similarity correlations) among relative abundances of bacteria, archaea, protists, total abundance of bacteria and viruses and physico-chemical parameters. We used a network generated from these statistical correlations to visualize and identify time-dependent associations among ecologically important taxa, for example, the SAR11 cluster, stramenopiles, alveolates, cyanobacteria and ammonia-oxidizing archaea. Negative correlations, perhaps suggesting competition or predation, were also common. The analysis revealed a progression of microbial communities through time, and also a group of unknown eukaryotes that were highly correlated with dinoflagellates, indicating possible symbioses or parasitism. Possible ‘keystone’ species were evident. The network has statistical features similar to previously described ecological networks, and in network parlance has non-random, small world properties (that is, highly interconnected nodes). This approach provides new insights into the natural history of microbes

Lipidomics Reveals Seasonal Shifts in a Large-Bodied Hibernator, the Brown Bear

Prior to winter, heterotherms retain polyunsaturated fatty acids (“PUFA”), resulting in enhanced energy savings during hibernation, through deeper and longer torpor bouts. Hibernating bears exhibit a less dramatic reduction (2–5°C) in body temperature, but lower their metabolism to a degree close to that of small hibernators. We determined the lipid composition, via lipidomics, in skeletal muscle and white adipose tissues (“WAT”), to assess lipid retention, and in blood plasma, to reflect lipid trafficking, of winter hibernating and summer active wild Scandinavian brown bears (Ursus arctos). We found that the proportion of monounsaturated fatty acids in muscle of bears was significantly higher during winter. During hibernation, omega-3 PUFAs were retained in WAT and short-length fatty acids were released into the plasma. The analysis of individual lipid moieties indicated significant changes of specific fatty acids, which are in line with the observed seasonal shift in the major lipid categories and can be involved in specific regulations of metabolisms. These results strongly suggest that the shift in lipid composition is well conserved among hibernators, independent of body mass and of the animals’ body temperature

The effect of obesity on spirometry tests among healthy non-smoking adults

<p>Abstract</p> <p>Introduction</p> <p>The effects of obesity on pulmonary functions have not been addressed previously among Saudi population. We aim to study the effects of obesity on spirometry tests among healthy non-smoking adults.</p> <p>Methods</p> <p>A cross sectional study conducted among volunteers healthy non-smoking adults Subjects. We divided the subjects into two groups according to their BMI. The first group consisted of non-obese subjects with BMI of 18 to 24.9 kg/m2 and the second group consisted of obese subjects with BMI of 30 kg/m2 and above. Subjects underwent spirometry tests according to American thoracic society standards with measurement of the following values: the forced vital capacity (FVC), forced expiratory volume in one second (FEV1), peak expiratory flow rate (PEF) and forced mid-expiratory flow (FEF25-75).</p> <p>Results</p> <p>The total subjects were 294 with a mean age of 32 years. There were 178 males and 116 females subjects. We found no significant differences in FEV1 (p value = 0.686), FVC (p value = 0.733), FEV1/FVC Ratio (p value = 0.197) and FEF25-75 (p value = 0.693) between the obese and non-obese subjects. However, there was significantly difference in PEF between the two groups (p value < 0.020).</p> <p>Conclusion</p> <p>Obesity does not have effect on the spirometry tests (except PEF) among health non-smoking adults. We recommend searching for alternative diagnosis in case of findings abnormal spirometry tests results among obese subjects.</p

Computer-Integrated Design and Manufacture of Integrated Circuits

Contains research goals and objectives, reports on sixteen research projects and a list of publications.Defense Advanced Research Projects Agency/U.S. Navy Contract N00174-93-K-0035Defense Advanced Research Projects Agency/U.S. Army Contract DABT 63-95-C-0088Multisponsored Projects Industrial/MIT Leaders for Manufacturing Progra