Negation Detection for Robust Adverse Drug Event Extraction From Social Media Texts

Adverse Drug Event (ADE) extraction from user-generated content has gained popularity as a tool to aid researchers and pharmaceutical companies to monitor side effect of drugs in the wild. Automatic models can rapidly examine large collections of social media texts. However it is currently unknown if such models are robust in face of linguistic phenomena such as negation and speculation, which are pervasive across language varieties. We evaluate three state-of-the-art systems, showing their fragility against negation, and then we introduce two possible strategies to increase the robustness of these models: (i) a pipeline approach, using a specific component for negation detection; (ii) an augmentation of the dataset with artificially negated samples to further train the models. We show that both strategies bring significant increases in performance

Osmotic blistering in enamel bonded with one-step self-etch adhesives

One-step self-etch adhesives behave as permeable membranes after polymerization, permitting water to move through the cured adhesives. We hypothesize that osmotic blistering occurs in bonded enamel when these adhesives are used without composite coupling. Tooth surfaces from extracted human premolars were bonded with 5 one-step self-etch adhesives. They were immersed in distilled water or 4.8 M CaCl2, and examined by stereomicroscopy, field-emission/environmental SEM, and TEM. Water blisters were observed in bonded enamel but not in bonded dentin when specimens were immersed in water. They collapsed when water was subsequently replaced with CaCl2. Blisters were absent from enamel in specimens that were immersed in CaCl 2 only. Water trees were identified from adhesive-enamel interfaces. Osmotic blistering in enamel is probably caused by the low water permeability of enamel. This creates an osmotic gradient between the bonded enamel and the external environment, causing water sorption into the interface.published_or_final_versio

In vivo and in vitro permeability of one-step self-etch adhesives

Adhesive dentistry should effectively restore the peripheral seal of dentin after enamel removal. We hypothesize that non-rinsing, simplified, one-step self-etch adhesives are effective for minimizing dentin permeability after tooth preparation procedures. Crown preparations in vital human teeth were sealed with Adper Prompt, Xeno III, iBond, or One-Up Bond F. Epoxy resin replicas were produced from polyvinyl siloxane impressions for SEM examination. Dentin surfaces from extracted human teeth were bonded with these adhesives and connected to a fluid-transport model for permeability measurements and TEM examination. Dentinal fluid droplets were observed from adhesive surfaces in resin replicas of in vivo specimens. In vitro fluid conductance of dentin bonded with one-step self-etch adhesives was either similar to or greater than that of smear-layer-covered dentin. TEM revealed water trees within the adhesives that facilitate water movement across the polymerized, highly permeable adhesives. Both in vitro and in vivo results did not support the proposed hypothesis.published_or_final_versio

Differential permeability reduction in single-bottle adhesives with an oxalate desensitizer

published_or_final_versio

Intra-radicular dentin treatments and retention of fiber posts with self-adhesive resin cements

The aim of this study was to evaluate the effect of treating intraradicular dentin with irrigating solutions on the retention of glass-fiber posts luted with self-adhesive resin cement. Bovine incisors were endodontically treated, and 9-mm-deep postholes were prepared. Before inserting the cement, the root canals were irrigated with various solutions: 11.5% polyacrylic acid for 30 s, 17% EDTA for 60 s, or 5% NaOCl for 60 s, respectively. Irrigation with distilled water was used in the control group. After all specimens had been rinsed with distilled water, the excess moisture was removed and the posts were luted using either BisCem (Bisco) or RelyX Unicem clicker (3M ESPE). Seven days after luting, the specimens were sectioned transversally into 1-mm-thick slices, which were submitted to push-out testing on a mechanical testing machine. Bond strength data (n = 6 per group) were analyzed by two-way ANOVA and Student-Newman-Keuls' test (α = 0.05). For Unicem, EDTA showed lower bond strength than the other solutions, which had similar results. For BisCem, EDTA showed higher bond strength than the other treatments, while application of NaOCl yielded higher bond strength than polyacrylic acid whereas the control group had intermediate results. In conclusion, irrigating root canals before insertion of self-adhesive resin cements, especially EDTA, might interfere with retention of the fiber posts

Are Frequent Phrases Directly Retrieved like Idioms? An Investigation with Self-paced Reading and Language Models

An open question in language comprehension studies is whether non-compositional multiword expressions like idioms and compositional-but-frequent word sequences are processed differently. Are the latter constructed online, or are instead directly retrieved from the lexicon, with a degree of entrenchment depending on their frequency? In this paper, we address this question with two different methodologies. First, we set up a self-paced reading experiment comparing human reading times for idioms and both highfrequency and low-frequency compositional word sequences. Then, we ran the same experiment using the Surprisal metrics computed with Neural Language Models (NLMs). Our results provide evidence that idiomatic and high-frequency compositional expressions are processed similarly by both humans and NLMs. Additional experiments were run to test the possible factors that could affect the NLMs’ performance

Dentine Permeability and Dentine Morphology after Treatment with Sanguinaria Canadensis and Chlorexidine

Toothpastes, mouthwashes, liners, that remove smear layer and increase the functional diameter of dentinal tubules may be responsible for hypersensitivity and pain. The aim of this study to evaluate in vitro the effect on dentin permeability of two mouthwashes proposed for periodontal therapy: Periogard with Sanguinaria Canadensis 0.03% (Colgate, USA) and Periogard with Chlorexidine 0.2% (Colgate, USA). Twenty-four occlusally sectioned crown segments from human extracted third molars were divided into four groups and connected to an in vitro hydraulic apparatus as described by Pashely et al. (1978). All groups were etched with 37% phosphoric acid gel (3M, USA) to remove the smear layer and to calculate the maximum permeability. In two groups, smear layer was recreated using #400 3M sandpaper disks. Finally, the undiluted mouthwashes were applied and brushed on the dentin for 3 minutes with a toothbrush (Colgate, USA). Each sample was then washed with water and dentin permeability was evaluated. Four measurements of permeability (expressed as hydraulic conductance in ml/min per cm H2O) were made for each sample the averaged. ANOVA tests and Paired Student's test were used where appropriate. SEM analysis was made on the same samples