Assessment of prospective risk of osteoporosis on the FRAX in patients with COPD

The article deals with the risk assessment of osteoporosis and prediction of hip fracture in patients withchronic obstructive pulmonary disease. The probability of osteoporosis was calculated using the FRAX in the group of patients undergoing treatment in the pulmonary hospital.В статье рассмотрены вопросы оценки риска остеопороза и прогнозирования перелома шейки бедра у больных хронической обструктивной болезнью легких. Вероятность развития остеопороза или перелома шейки бедра была рассчитана с помощью шкалы FRAX в группе пациентов, проходящих лечение в пульмонологическом стационаре

Surgical tactics for polyps of the gallbladder in children.

The article considers the validity of surgical treatment tactics in children with gallbladder polypsВ статье рассмотрены вопросы обоснования хирургической тактики лечения в объеме холецистэктомии у детей с полипами желчного пузыря

Circulatory system disease rates in the population of Yekaterinburg and the analysis of contributing behavioral risk factors

The aim of the study – to assess changes in incidence and prevalence rates of heart diseases in the population of the city of Yekaterinburg in 2016–2020 and to examine behavioral risk factors of these disorders.Цель исследования – оценить динамику общей и первичной заболеваемости болезнями системы кровообращения населения города Екатеринбург за период с 2016-2020 годы и изучить поведенческие факторы риска их возникновения

Constructing g-C3N4/Cd1−xZnxS-Based Heterostructures for Efficient Hydrogen Production under Visible Light

Two types of photocatalysts, 1%Pt/Cd1−x Znx S/g-C3 N4 (x = 0.2–0.3) and Cd1−x Znx S/1% Pt/g-C3 N4 (x = 0.2–0.3), were synthesized by varying the deposition order of platinum, and a solid solution of cadmium and zinc sulfides onto the surface of g-C3 N4. The characterization of photo-catalysts showed that, for 1%Pt/Cd1−x Znx S/g-C3 N4, small platinum particles were deposited onto a solid solution of cadmium and zinc sulfides; in the case of Cd1−x Znx S/1%Pt/g-C3 N4, enlarged platinum clusters were located on the surface of graphitic carbon nitride. Based on the structure of the photocatalysts, we assumed that, in the first case, type II heterojunctions and, in the latter case, S-scheme heterojunctions were realized. The activity of the synthesized samples was tested in hydrogen evolution from triethanolamine (TEOA) basic solution under visible light (λ = 450 nm). A remarkable increase in hydrogen evolution rate compared to single-phase platinized 1%Pt/Cd1−x Znx S photocat-alysts was observed only in the case of ternary photocatalysts with platinum located on the g-C3 N4 surface, Cd1−x Znx S/1%Pt/g-C3 N4. Thus, we proved using kinetic experiments and characterization techniques that, for composite photocatalysts based on Cd1−x Znx S and g-C3 N4, the formation of the S-scheme mechanism is more favorable than that for type II heterojunction. The highest activity, 2.5 mmol H2 g−1 h−1, with an apparent quantum efficiency equal to 6.0% at a wavelength of 450 nm was achieved by sample 20% Cd0.8 Zn0.2 S/1% Pt/g-C3 N4. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Funding: This work was supported by the Ministry of Science and Higher Education of the Russian Federation within the governmental order for Boreskov Institute of Catalysis (project AAAA-A21-121011390009-1) and was also funded by the Russian Foundation for Basic Research (project No. 20-33-70086). A.S.V. and I.A.W. thank Minobrnauki research project FEUZ-2020-0059 for financial support

DETERMINATION OF THE GRAN SIZE OF MICRON POWDERS ZrO2−5 МАСС.%Y2O3 AND POWDER COMPOSITIONS (ZrO2−5 МАСС.%Y2O3) − Al2O3

In the presented work, the values of the gran size of micron powders 2 ZrO -5 wt.% 2 3 Y O and powder compositions ( 2 ZrO -5 wt.% 2 3 Y O ) - 2 3 Al O obtained by precipitation nanostructured powders Al2O3 on micron powders 2 ZrO -5 wt.% 2 3 Y O are compared

THE STUDY OF THE MORPHOLOGY OF PARTICLES OF MICRON POWDERS ZrO2−5 МАСС.%Y2O3

In this work the morphology of particles of ZrO2 -5% wt. 2 3 Y O powder, prepared by reverse precipitation, using scanning electron microscopy, was studed

DETERMINATION OF THE SPECIFIC SURFACE AREA OF MICRON POWDERSZrO2−5 МАСС.%Y2O3 AND POWDER COMPOSITIONS(ZrO2−5 МАСС.%Y2O3)− Al2O3

In the presented work, the values of the specific surface area of micron powders 2 ZrO -5 wt.% 2 3 Y O and powder compositions ( 2 ZrO -5 wt.% 2 3 Y O ) - 2 3 Al O obtained by precipitation nanostructured powders Al2O3 on micron powders 2 ZrO -5 wt.% 2 3 Y O are compared

Oligosaccharyltransferase Inhibition Induces Senescence in RTK-Driven Tumor Cells

Asparagine (N)-linked glycosylation is a protein modification critical for glycoprotein folding, stability, and cellular localization. To identify small molecules that inhibit new targets in this biosynthetic pathway, we initiated a cell-based high throughput screen and lead compound optimization campaign that delivered a cell permeable inhibitor (NGI-1). NGI-1 targets the oligosaccharyltransferase (OST), a hetero-oligomeric enzyme that exists in multiple isoforms and transfers oligosaccharides to recipient proteins. In non-small cell lung cancer cells NGI-1 blocks cell surface localization and signaling of the EGFR glycoprotein, but selectively arrests proliferation in only those cell lines that are dependent on EGFR (or FGFR) for survival. In these cell lines OST inhibition causes cell cycle arrest accompanied by induction of p21, autofluorescence, and changes in cell morphology; all hallmarks of senescence. These results identify OST inhibition as a potential therapeutic approach for treating receptor tyrosine kinase-dependent tumors and provides a chemical probe for reversibly regulating N-linked glycosylation in mammalian cells

STUDY OF THE PHASE COMPOSITION OF MICRON POWDERS ZrO2−5 МАСС.% Y2O3

In the presented work, X-ray analysis of micron powders ZrO2 -5 wt.% 2 3 Y O obtained by reverse precipitation was carried out

Stochastic Inversion of P-to-S Converted Waves for Mantle Composition and Thermal Structure: Methodology and Application

We present a new methodology for inverting P‐to‐S receiver function (RF) waveforms directly for mantle temperature and composition. This is achieved by interfacing the geophysical inversion with self‐consistent mineral phase equilibria calculations from which rock mineralogy and its elastic properties are predicted as a function of pressure, temperature, and bulk composition. This approach anchors temperatures, composition, seismic properties, and discontinuities that are in mineral physics data, while permitting the simultaneous use of geophysical inverse methods to optimize models of seismic properties to match RF waveforms. Resultant estimates of transition zone (TZ) topography and volumetric seismic velocities are independent of tomographic models usually required for correcting for upper mantle structure. We considered two end‐member compositional models: the equilibrated equilibrium assemblage (EA) and the disequilibrated mechanical mixture (MM) models. Thermal variations were found to influence arrival times of computed RF waveforms, whereas compositional variations affected amplitudes of waves converted at the TZ discontinuities. The robustness of the inversion strategy was tested by performing a set of synthetic inversions in which crustal structure was assumed both fixed and variable. These tests indicate that unaccounted‐for crustal structure strongly affects the retrieval of mantle properties, calling for a two‐step strategy presented herein to simultaneously recover both crustal and mantle parameters. As a proof of concept, the methodology is applied to data from two stations located in the Siberian and East European continental platforms.This work was supported by a grant from the Swiss National Science Foundation (SNF project 200021_159907). B. T. was funded by a Délégation CNRS and Congé pour Recherches et Conversion Thématique from the Université de Lyon to visit the Research School of Earth Sciences (RSES), The Australian National University (ANU). B. T. has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement 79382