Impact of global SST gradients on the Mediterranean runoff changes across the Plio-Pleistocene transition

This work explores the impact of the development of global meridional and zonal sea surfacetemperature (SST) gradients on the Mediterranean runoff variability during the Plio-Pleistocene transition,about 3 Ma. Results show that total annual mean Pliocene Mediterranean runoff is about 40% larger thanduring the preindustrial period due to more increased extratropical specific humidity. As a consequenceof a weakened and extended Hadley cell, the Pliocene northwest Africa hydrological network producesa discharge 30 times larger than today. Our results support the conclusion that during the Pliocene, theMediterranean water deficit was reduced relative to today due to a larger river discharge. By means ofa stand-alone atmospheric general circulation model, we simulate the separate impact of extratropicaland equatorial SST cooling on the Mediterranean runoff. While cooling the equatorial SST does not implysignificant changes to the Pliocene Mediterranean hydrological budget, the extratropical SST coolingincreases the water deficit due to a decrease in precipitation and runoff. Consequently, river dischargefrom this area reduces to preindustrial levels. The main teleconnections acting upon the Mediterraneanarea today, i.e., the North Atlantic Oscillation during winter and the “monsoon-desert” mechanism duringsummer already have a large influence on the climate of our Pliocene simulations. Finally, our results alsosuggest that in a climate state significantly warmer than today, changes of the Hadley circulation couldpotentially lead to increased water resources in northwest Africa

Impact of Orbital Parameters and Greenhouse Gas on the Climate of MIS 7 and MIS 5 Glacial Inceptions

This work explores the impact of orbital parameters and greenhouse gas concentrations on the climate of marine isotope stage (MIS) 7 glacial inception and compares it to that of MIS 5. The authors use a coupled atmosphere-ocean general circulation model to simulate the mean climate state of six time slices at 115, 122, 125, 229, 236, and 239 kyr, representative of a climate evolution from interglacial to glacial inception conditions. The simulations are designed to separate the effects of orbital parameters from those of greenhouse gas (GHG). Their results show that, in all the time slices considered, MIS 7 boreal lands mean annual climate is colder than the MIS 5 one. This difference is explained at 70% by the impact of the MIS 7 GHG. While the impact of GHG over Northern Hemisphere is homogeneous, the difference in temperature between MIS 7 and MIS 5 due to orbital parameters differs regionally and is linked with the Arctic Oscillation. The perennial snow cover is larger in all the MIS 7 experiments compared to MIS 5, as a result of MIS 7 orbital parameters, strengthened by GHG. At regional scale, Eurasia exhibits the strongest response to MIS 7 cold climate with a perennial snow area 3 times larger than in MIS 5 experiments. This suggests that MIS 7 glacial inception is more favorable over this area than over North America. Furthermore, at 239 kyr, the perennial snow covers an area equivalent to that of MIS 5 glacial inception (115 kyr). The authors suggest that MIS 7 glacial inception is more extensive than MIS 5 glacial inception over the high latitudes

Heatwaves in Europe: areas of homogeneous variability and links with the regional to large-scale atmospheric and SSTs anomalies

This work presents a methodology to study the interannual variability associated with summertime months in which extremely hot temperatures are frequent. Daily time series of maximum and minimum temperature fields (T max and T min, respectively) are used to define indexes of extreme months based on the number of days crossing thresholds. An empirical orthogonal function (EOF) analysis is applied to the monthly indexes. EOF loadings give information about the geographical areas where the number of days per month with extreme temperatures has the largest variability. Correlations between the EOF principal components and the time series of other fields allow plotting maps highlighting the anomalies in the large scale circulation and in the SSTs that are associated with the occurrence of extreme events. The methodology is used to construct the “climatology” of the extremely hot summertime months over Europe. In terms of both interannual and intraseasonal variability, there are three regions in which the frequency of the extremely hot days per month homogeneously varies: north-west Europe, Euro-Mediterranean and Eurasia region. Although extremes over those regions occur during the whole summer (June to August), the anomalous climatic conditions associated with frequent heatwaves present some intraseasonal variability. Extreme climate events over the north-west Europe and Eurasia are typically related to the occurrence of blocking situations. The intraseasonal variability of those patterns is related to the amplitude of the blocking, the relative location of the action centre and the wavetrain of anomalies downstream or upstream of the blocking. During June and July, blocking situations which give extremely hot climate conditions over north-west Europe are also associated with cold conditions over the eastern Mediterranean sector. The Euro-Mediterranean region is a transition area in which extratropical and tropical systems compete, influencing the occurrence of climate events: blockings tend to be related to extremely hot months during June while baroclinic anomalies dominate the variability of the climate events in July and August. We highlight that our method could be easily applied to other regions of the world, to other fields as well as to model outputs to assess, e.g. the potential change of extreme climate events in a warmer climate

Automated generation of flat tileable patterns and 3D reduced model simulation

The computational fabrication community is developing an increasing interest in the use of patterned surfaces, which can be designed to show ornamental and unconventional aesthetics or to perform as a proper structural material with a wide range of features. Geometrically designing and controlling the deformation capabilities of these patterns in response to external stimuli is a complex task due to the large number of variables involved. This paper introduces a method for generating sets of tileable and exchangeable flat patterns as well as a model-reduction strategy that enables their mechanical simulation at interactive rates. This method is included in a design pipeline that aims to turn any general flat surface into a pattern tessellation, which is able to deform under a given loading scenario. To validate our approach, we apply it to different contexts, including real-scale 3D printed specimens, for which we compare our results with the ones provided by a ground-truth solver

HexBox: Interactive Box Modeling of Hexahedral Meshes

We introduce HexBox, an intuitive modeling method and interactive tool for creating and editing hexahedral meshes. Hexbox brings the major and widely validated surface modeling paradigm of surface box modeling into the world of hex meshing. The main idea is to allow the user to box-model a volumetric mesh by primarily modifying its surface through a set of topological and geometric operations. We support, in particular, local and global subdivision, various instantiations of extrusion, removal, and cloning of elements, the creation of non-conformal or conformal grids, as well as shape modifications through vertex positioning, including manual editing, automatic smoothing, or, eventually, projection on an externally-provided target surface. At the core of the efficient implementation of the method is the coherent maintenance, at all steps, of two parallel data structures: a hexahedral mesh representing the topology and geometry of the currently modeled shape, and a directed acyclic graph that connects operation nodes to the affected mesh hexahedra. Operations are realized by exploiting recent advancements in grid- based meshing, such as mixing of 3-refinement, 2-refinement, and face-refinement, and using templated topological bridges to enforce on-the-fly mesh conformity across pairs of adjacent elements. A direct manipulation user interface lets users control all operations. The effectiveness of our tool, released as open source to the community, is demonstrated by modeling several complex shapes hard to realize with competing tools and techniques

A2B Adenosine Receptors and Sphingosine 1-Phosphate Signaling Cross-Talk in Oligodendrogliogenesis

Oligodendrocyte-formed myelin sheaths allow fast synaptic transmission in the brain. Impairments in the process of myelination, or demyelinating insults, might cause chronic diseases such as multiple sclerosis (MS). Under physiological conditions, remyelination is an ongoing process throughout adult life consisting in the differentiation of oligodendrocyte progenitor cells (OPCs) into mature oligodendrocytes (OLs). During pathological events, this process fails due to unfavorable environment. Adenosine and sphingosine kinase/sphingosine 1-phosphate signaling axes (SphK/S1P) play important roles in remyelination processes. Remarkably, fingolimod (FTY720), a sphingosine analog recently approved for MS treatment, plays important roles in OPC maturation. We recently demonstrated that the selective stimulation of A(2)(B) adenosine receptors (A(2)(B)Rs) inhibit OPC differentiation in vitro and reduce voltage-dependent outward K(+) currents (I(K)) necessary to OPC maturation, whereas specific SphK1 or SphK2 inhibition exerts the opposite effect. During OPC differentiation A(2)(B)R expression increases, this effect being prevented by SphK1/2 blockade. Furthermore, selective silencing of A(2)(B)R in OPC cultures prompts maturation and, intriguingly, enhances the expression of S1P lyase, the enzyme responsible for irreversible S1P catabolism. Finally, the existence of an interplay between SphK1/S1P pathway and A(2)(B)Rs in OPCs was confirmed since acute stimulation of A(2)(B)Rs activates SphK1 by increasing its phosphorylation. Here the role of A(2)(B)R and SphK/S1P signaling during oligodendrogenesis is reviewed in detail, with the purpose to shed new light on the interaction between A(2)(B)Rs and S1P signaling, as eventual innovative targets for the treatment of demyelinating disorders

Distribution of HLA-DPB1, -DQB1 -DQA1 alleles among Sardinian celiac patients.

The Sardinian population in many aspects differs from other Caucasoid populations, particularly for its degree of homogeneity. For this reason we have studied 50 adult Sardinian patients with celiac disease (CD) and 50 control healthy Sardinian individuals by RFLP analysis and by extensive oligotyping for 17 HLA-DPB 1, 8-DQB I and 9-DQA 1 alleles, and established their -DPB I alleles and -DQB I -DQA I genotypes. The heterodimer HLA-DQB 1 *0201/-DQA 1 *0501, present in 96% of our patients, is strongly associated with CD susceptibility, confirming published reports. On the other hand we found in 11 of 50 probands (22%) the presence of the allele -DQB 1 *05021 DQA1*0102. This genotype is extremely rare in other Caucasian populations and appears to confer limited protection in CD Sardinian patients