European clinical guidelines for Tourette syndrome and other tic disorders. Part II: pharmacological treatment

To develop a European guideline on pharmacologic treatment of Tourette syndrome (TS) the available literature was thoroughly screened and extensively discussed by a working group of the European Society for the Study of Tourette syndrome (ESSTS). Although there are many more studies on pharmacotherapy of TS than on behavioral treatment options, only a limited number of studies meets rigorous quality criteria. Therefore, we have devised a two-stage approach. First, we present the highest level of evidence by reporting the findings of existing Cochrane reviews in this field. Subsequently, we provide the first comprehensive overview of all reports on pharmacological treatment options for TS through a MEDLINE, PubMed, and EMBASE search for all studies that document the effect of pharmacological treatment of TS and other tic disorders between 1970 and November 2010. We present a summary of the current consensus on pharmacological treatment options for TS in Europe to guide the clinician in daily practice. This summary is, however, rather a status quo of a clinically helpful but merely low evidence guideline, mainly driven by expert experience and opinion, since rigorous experimental studies are scarce

Comparação entre métodos de determinação da biomassa microbiana baseados no princípio da fumigação e extração.

We report measurement of the cross section of $e^+e^-\to \pi^+\pi^-\psi(2S)$ between 4.0 and $5.5 {\rm GeV}$, based on an analysis of initial state radiation events in a $980 \rm fb^{-1}$ data sample recorded with the Belle detector. The properties of the $Y(4360)$ and $Y(4660)$ states are determined. Fitting the mass spectrum of $\pi^+\pi^-\psi(2S)$ with two coherent Breit-Wigner functions, we find two solutions with identical mass and width but different couplings to electron-positron pairs: $M_{Y(4360)} = (4347\pm 6\pm 3) {\rm MeV}/c^2$, $\Gamma_{Y(4360)} = (103\pm 9\pm 5) {\rm MeV}$, $M_{Y(4660)} = (4652\pm10\pm 8) {\rm MeV}/c^2$, $\Gamma_{Y(4660)} = (68\pm 11\pm 1) \rm MeV$; and ${\cal{B}}[Y(4360)\to \pi^+\pi^-\psi(2S)]\cdot \Gamma_{Y(4360)}^{e^+e^-} = (10.9\pm 0.6\pm 0.7) \rm eV$ and ${\cal{B}}[Y(4660)\to \pi^+\pi^-\psi(2S)]\cdot \Gamma_{Y(4660)}^{e^+e^-} = (8.1\pm 1.1\pm 0.5) \rm eV$ for one solution; or ${\cal{B}}[Y(4360)\to \pi^+\pi^-\psi(2S)]\cdot \Gamma_{Y(4360)}^{e^+e^-} = (9.2\pm 0.6\pm 0.6) \rm eV$ and ${\cal{B}}[Y(4660)\to \pi^+\pi^-\psi(2S)]\cdot \Gamma_{Y(4660)}^{e^+e^-} = (2.0\pm 0.3\pm 0.2) \rm eV$ for the other. Here, the first errors are statistical and the second systematic. Evidence for a charged charmoniumlike structure at $4.05 {\rm GeV}/c^2$ is observed in the $\pi^{\pm}\psi(2S)$ intermediate state in the $Y(4360)$ decays.Comment: 21 pages, 12 figure

International Consensus Statement on Rhinology and Allergy: Rhinosinusitis

Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS