Seismic Effect of the Offshore Structure Under Different Earthquake Loadings

Peninsular Malaysia is most affected by the distant Sumatra subduction zone earthquake. Meanwhile, Eastern Malaysia was subjected to major Philippine and Indonesian earthquake. Most of the offshore platform is at Terengganu, Sabah, and Sarawak. More than 65% of the offshore platform structure exceed the range of design between 20-30 years. This research aims to determine the vulnerability and risk analysis for the existing 3-legged offshore platform under earthquake load, study the behaviors of an offshore platform under major or minor earth-quake loading, and study the dynamic characteristic of an offshore platform. SAP 2000 is use to analyses and modelling the 3-legged offshore platform. In SAP 2000, the response spectrum, time history, and free vibration will be performed. The mixed load of the platform consists of dead load, imposed load, environment loads, and earthquake load. The position of the offshore platform has referred to American Petroleum Institute (API) standard. The major earthquake under off-shore platform is El-Centro and the minor is Aceh compared to time history. Based on this study, Malaysia can withstand this low seismic activity, overall joint acceleration, velocity and displacement

Seismic Effect of the Offshore Structure Under Different Earthquake Loadings

Peninsular Malaysia is most affected by the distant Sumatra subduction zone earthquake. Meanwhile, Eastern Malaysia was subjected to major Philippine and Indonesian earthquake. Most of the offshore platform is at Terengganu, Sabah, and Sarawak. More than 65% of the offshore platform structure exceed the range of design between 20-30 years. This research aims to determine the vulnerability and risk analysis for the existing 3-legged offshore platform under earthquake load, study the behaviors of an offshore platform under major or minor earth-quake loading, and study the dynamic characteristic of an offshore platform. SAP 2000 is use to analyses and modelling the 3-legged offshore platform. In SAP 2000, the response spectrum, time history, and free vibration will be performed. The mixed load of the platform consists of dead load, imposed load, environment loads, and earthquake load. The position of the offshore platform has referred to American Petroleum Institute (API) standard. The major earthquake under off-shore platform is El-Centro and the minor is Aceh compared to time history. Based on this study, Malaysia can withstand this low seismic activity, overall joint acceleration, velocity and displacement

Mechanistic mathematical modelling of mercaptopurine effects on cell cycle of human acute lymphoblastic leukaemia cells

The antimetabolite mercaptopurine (MP) is widely used to treat childhood acute lymphoblastic leukaemia (ALL). To study the dynamics of MP on the cell cycle, we incubated human T-cell leukaemia cell lines (Molt-4 sensitive and resistant subline and P12 resistant) with 10 μM MP and measured total cell count, cell cycle distribution, percent viable, percent apoptotic, and percent dead cells serially over 72 h. We developed a mathematical model of the cell cycle dynamics after treatment with MP and used it to show that the Molt-4 sensitive controls had a significantly higher rate of cells entering apoptosis (2.7-fold, P<0.00001) relative to the resistant cell lines. Additionally, when treated with MP, the sensitive cell line showed a significant increase in the rate at which cells enter apoptosis compared to its controls (2.4-fold, P<0.00001). Of note, the resistant cell lines had a higher rate of antimetabolite incorporation into the DNA of viable cells (>1.4-fold, P<0.01). Lastly, in contrast to the other cell lines, the Molt-4 resistant subline continued to cycle, though at a rate slower relative to its control, rather than proceed to apoptosis. This led to a larger S-phase block in the Molt-4 resistant cell line, but not a higher rate of cell death. Gene expression of apoptosis, cell cycle, and repair genes were consistent with mechanistic dynamics described by the model. In summary, the mathematical model provides a quantitative assessment to compare the cell cycle effects of MP in cells with varying degrees of MP resistance

Squalus acanthias, spiny dogfish

While there are reported subpopulations of Squalus acanthias (Linnaeus, 1758) elsewhere in the world, the North Pacific subpopulation is now considered a separate species, Squalus suckleyi (Girard, 1854) (see Ebert et al. 2010). Further taxonomic studies on this genus are required, including in relation to Mediterranean and Black Sea subpopulations. In Europe, three subpopulations are inferred to occur.Fil: Finucci, B.. National Institute of Water and Atmospheric Research; Nueva ZelandaFil: Cheok, J.. University Fraser Simon; CanadáFil: Chiaramonte, Gustavo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia". Estación Hidrobiológica de Puerto Quequén (sede Quequén); ArgentinaFil: Cotton, C. F.. Florida State University; Estados UnidosFil: Dulvy, N. K.. University Fraser Simon; CanadáFil: Kulka, D. W.. No especifíca; ArgentinaFil: Neat, F. C.. No especifíca; ArgentinaFil: Pacoureau, N.. University Fraser Simon; CanadáFil: Rigby, C. L.. James Cook University; AustraliaFil: Tanaka, S.. No especifíca; ArgentinaFil: Walker, T. I.. University of Melbourne; Australi

Structure vulnerability and risk analysis of 3-legged offshore structure

Peninsular Malaysia is most affected by the distant Sumatra subduction zone earthquake. Meanwhile, Eastern Malaysia was subjected to major Philippine and Indonesian earthquake. Most of the offshore platform is at Terengganu, Sabah, and Sarawak. More than 65% of the offshore platform structure exceed the range of design between 20-30 years. This research aims to determine the vulnerability and risk analysis for the existing 3-legged offshore platform under earthquake load, study the behaviors of an offshore platform under major or minor earthquake loading, and study the dynamic characteristic of an offshore platform. SAP 2000 is use to analyses and modelling the 3-legged offshore platform. In SAP 2000, the response spectrum, time history, and free vibration will be performed. The mixed load of the platform consists of dead load, imposed load, environment loads, and earthquake load. The position of the offshore platform has referred to American Petroleum Institute (API) standard. The major earthquake under off-shore platform is El-Centro and the minor is Aceh compared to time history. Based on this study, Malaysia can withstand this low seismic activity, overall joint acceleration, velocity and displacement

Structure vulnerability and risk analysis of 4-legged offshore structure

Offshore structures are commonly used in oil and gas collecting sector. This industry is one of the major economic sector in Malaysia. Since distant earthquakes from neighbour countries (Indonesia and Philippines) had caused significant structural damages in the past few years, the perfomance level of offshore due to seismic effect need to be undergone detailed investigation. Therefore, this research aims to investigate the vulnerability and analyze the risk of 4-legged fixed offshore structure under different excitations. In order to achieve the objectives, SAP 2000 was chosen to analyze the offshore structure modelling by referring to the API (American Petroleum Institute) criteria. Time history, response spectrum and free vibration analysis have been performed. The behaviour of the offshore structure was observed and evaluated through the natural frequencies and periods. Meanwhile, results outcome of the joint displacement, velocity, and acceleration represented the dynamic characteristic of the structure. The 4-legged fixed offshore structure categorized as Immediate Occupancy (IO) based on FEMA 356 guidelines. From the results, it showed that existing 4-legged offshore structures in Malaysia are capable to resist seismic loads and in stable condition

Seismic Effect of the Offshore Structure Under Different Earthquake Loadings

Peninsular Malaysia is most affected by the distant Sumatra subduction zone earthquake. Meanwhile, Eastern Malaysia was subjected to major Philippine and Indonesian earthquake. Most of the offshore platform is at Terengganu, Sabah, and Sarawak. More than 65% of the offshore platform structure exceed the range of design between 20-30 years. This research aims to determine the vulnerability and risk analysis for the existing 3-legged offshore platform under earthquake load, study the behaviors of an offshore platform under major or minor earth-quake loading, and study the dynamic characteristic of an offshore platform. SAP 2000 is use to analyses and modelling the 3-legged offshore platform. In SAP 2000, the response spectrum, time history, and free vibration will be performed. The mixed load of the platform consists of dead load, imposed load, environment loads, and earthquake load. The position of the offshore platform has referred to American Petroleum Institute (API) standard. The major earthquake under off-shore platform is El-Centro and the minor is Aceh compared to time history. Based on this study, Malaysia can withstand this low seismic activity, overall joint acceleration, velocity and displacement

In Vivo Response to Methotrexate Forecasts Outcome of Acute Lymphoblastic Leukemia and Has a Distinct Gene Expression Profile

William Evans and colleagues investigate the genomic determinants of methotrexate resistance and interpatient differences in methotrexate response in patients newly diagnosed with childhood acute lymphoblastic leukemia

Brexucabtagene autoleucel for relapsed or refractory mantle cell lymphoma in the United Kingdom: A real-world intention-to-treat analysis

\ua9 2024 The Authors. HemaSphere published by John Wiley &amp; Sons Ltd on behalf of European Hematology Association. Brexucabtagene autoleucel (brexu-cel) is an autologous CD19 CAR T-cell product, approved for relapsed/refractory (r/r) mantle cell lymphoma (MCL). In ZUMA-2, brexu-cel demonstrated impressive responses in patients failing ≥2 lines, including a bruton\u27s tyrosine kinase inhibitor, with an overall and complete response rate of 93% and 67%, respectively. Here, we report our real-world intention-to-treat (ITT) outcomes for brexu-cel in consecutive, prospectively approved patients, from 12 institutions in the United Kingdom between February 2021 and June 2023, with a focus on feasibility, efficacy, and tolerability. Of 119 approved, 104 underwent leukapheresis and 83 received a brexu-cel infusion. Progressive disease (PD) and/or manufacturing (MF) were the most common reasons for failure to reach harvest and/or infusion. For infused patients, best overall and complete response rates were 87% and 81%, respectively. At a median follow-up of 13.3 months, median progression-free survival (PFS) for infused patients was 21 months (10.1–NA) with a 6- and 12-month PFS of 82% (95% confidence interval [CI], 71–89) and 62% (95% CI, 49–73), respectively. ≥Grade 3 cytokine release syndrome and neurotoxicity occurred in 12% and 22%, respectively. On multivariate analysis, inferior PFS was associated with male sex, bulky disease, ECOG PS &gt; 1 and previous MF. Cumulative incidence of non-relapse mortality (NRM) was 6%, 15%, and 25% at 6, 12, and 24 months, respectively, and mostly attributable to infection. Outcomes for infused patients in the UK are comparable to ZUMA-2 and other real-world reports. However, ITT analysis highlights a significant dropout due to PD and/or MF. NRM events warrant further attention