DESIGN AND INTENSITY ANALYSIS OF PORTABLE ADVERTISEMENT CLEANING MACHINE

According to the demand of outdoor rubbish advertisement cleaning,the design idea of a portable garbage advertisement cleaning machine is put forward. Its structure and function are designed and analyzed. The cleaning machine is mainly composed of a floating brush,a guide rod and a box. Driven by electricity,the brush rotates at the speed of 3000 r / min.The static method is used to analyze the stress of the brush and the guide rod,the mathematical model of brush is established,and the optimum solution of brush size and motor power is obtained by using MATLAB. the three-dimensional solid model of the cleaning machine is established by pro / E,static and modal analysis of brush are completed using ANSYS. The results showed that the stress is less than the allowable stress,And the stiffness was preferably,it is satisfied to design requirements. It provided a new method and idea for the research of this kind of cleaning machine

Scale-reconfigurable miniature ferrofluidic robots for negotiating sharply variable spaces

Magnetic miniature soft robots have shown great potential for facilitating biomedical applications by minimizing invasiveness and possible physical damage. However, researchers have mainly focused on fixed-size robots, with their active locomotion accessible only when the cross-sectional dimension of these confined spaces is comparable to that of the robot. Here, we realize the scale-reconfigurable miniature ferrofluidic robots (SMFRs) based on ferrofluid droplets and propose a series of control strategies for reconfiguring SMFR's scale and deformation to achieve trans-scale motion control by designing a multiscale magnetic miniature robot actuation (M3RA) system. The results showed that SMFRs, varying from centimeters to a few micrometers, leveraged diverse capabilities, such as locomotion in structured environments, deformation to squeeze through gaps, and even reversible scale reconfiguration for navigating sharply variable spaces. A miniature robot system with these capabilities combined is promising to be applied in future wireless medical robots inside confined regions of the human body.ISSN:2375-254

Alternative transcribed 3' isoform of long non-coding RNA Malat1 inhibits mouse retinal oxidative stress

Summary: The function of the cancer-associated lncRNA Malat1 during aging is as-of-yet uncharacterized. Here, we show that Malat1 interacts with Nucleophosmin (NPM) in young mouse brain, and with Lamin A/C, hnRNP C, and KAP1 with age. RNA-seq and RT-qPCR reveal a persistent expression of Malat1_2 (the 3’isoform of Malat1) in Malat1Δ1 (5’-1.5 kb deletion) mouse retinas and brains at 1/4th level of the full-length Malat1, while Malat1_1 (the 5’isoform) in Malat1Δ2 (deletion of 3’-conserved 5.7 kb) at a much lower level, suggesting an internal promoter driving the 3’ isoform. The 1774 and 496 differentially expressed genes in Malat1Δ2 and Malat1Δ1 brains, respectively, suggest the 3’ isoform regulates gene expression in trans and the 5’ isoform in cis. Consistently, Malat1Δ2 mice show increased age-dependent retinal oxidative stress and corneal opacity, while Malat1Δ1 mice show no obvious phenotype. Collectively, this study reveals a physiological function of the lncRNA Malat1 3’-isoform during the aging process