Aerodynamic optimization of NACA 0012 airfoils with attached Gurney flap in the rarefied gas flow

The aerodynamic optimization of a Gurney flap attached to the NACA 0012 airfoil in rarefied gas flow is studied in this study. In order to investigate the effects of Gurney flap geometry (height, mounting angle, and mounting location) and angle of attack on the aerodynamic characteristics of the airfoil in the rarefied gas flow, the flow fields around NACA 0012 airfoils with Gurney flap attached are simulated by using the direct simulation Monte Carlo method. Furthermore, the multi-objective aerodynamic optimization of the airfoil with Gurney flap is performed at the single design point, and the Pareto front is obtained. Based on the benchmark configuration (obtained from the Pareto front), aerodynamic optimization by controlling the mounting angle of the Gurney flap and the angle of attack is investigated over a wide range of Mach numbers (ranging from 2 to 4) and Knudsen numbers (ranging from 0.024 to 0.24) by constructing an artificial neural network model. The results show that through optimization, the lift-to-drag ratio of the airfoil is increased by up to 29.25% under the combination of different Mach numbers and Knudsen numbers, which significantly improves the aerodynamic characteristics

Dense Pure Tungsten Fabricated by Selective Laser Melting

Additive manufacturing using tungsten, a brittle material, is difficult because of its high melting point, thermal conductivity, and oxidation tendency. In this study, pure tungsten parts with densities of up to 18.53 g/cm3 (i.e., 96.0% of the theoretical density) were fabricated by selective laser melting. In order to minimize balling effects, the raw polyhedral tungsten powders underwent a spheroidization process before laser consolidation. Compared with polyhedral powders, the spherical powders showed increased laser absorptivity and packing density, which helped in the formation of a continuous molten track and promoted densification

Towards Clinical Translation of CD8+ Regulatory T Cells Restricted by Non-Classical Major Histocompatibility Complex Ib Molecules

In central lymphoid tissues, mature lymphocytes are generated and pathogenic autoreactive lymphocytes are deleted. However, it is currently known that a significant number of potentially pathogenic autoreactive lymphocytes escape the deletion and populate peripheral lymphoid tissues. Therefore, peripheral mechanisms are present to prevent these potentially pathogenic autoreactive lymphocytes from harming one’s own tissues. One such mechanism is dictated by regulatory T (Treg) cells. So far, the most extensively studied Treg cells are CD4+Foxp3+ Treg cells. However, recent clinical trials for the treatment of immune-mediated diseases using CD4+ Foxp3+ Treg cells met with limited success. Accordingly, it is necessary to explore the potential importance of other Treg cells such as CD8+ Treg cells. In this regard, one extensively studied CD8+ Treg cell subset is Qa-1(HLA-E in human)-restricted CD8+ Treg cells, in which Qa-1(HLA-E) molecules belong to a group of non-classical major histocompatibility complex Ib molecules. This review will first summarize the evidence for the presence of Qa-1-restricted CD8+ Treg cells and their regulatory mechanisms. Major discussions will then focus on the potential clinical translation of Qa-1-restricted CD8+ Treg cells. At the end, we will briefly discuss the current status of human studies on HLA-E-restricted CD8+ Treg cells as well as potential future directions

Construction of Cellular Substructure in Laser Powder Bed Fusion

Cellular substructure has been widely observed in the sample fabricated by laser powder bed fusion, while its growth direction and the crystallographic orientation have seldom been studied. This research tries to build a general model to construct the substructure from its two-dimensional morphology. All the three Bunge Euler angles to specify a unique growth direction are determined, and the crystallographic orientation corresponding to the growth direction is also obtained. Based on the crystallographic orientation, the substructure in the single track of austenitic stainless steel 316L is distinguished between the cell-like dendrite and the cell. It is found that, with the increase of scanning velocity, the substructure transits from cell-like dendrite to cell. When the power is 200 W, the critical growth rate of the transition in the single track can be around 0.31 ms−1

Corrosion behavior of laser powder bed fusion additive manufacturing produced TiNi alloy by micro-arc oxidation

Abstract To improve the corrosion resistance of TiNi alloy fabricated by laser powder bed fusion (LPBF), a porous oxidation layer was synthesized by micro-arc oxidation in a sodium aluminate and sodium silicate electrolyte. The influences of the applied voltage and the processing time on the morphology of oxidation layer were investigated, and the corrosion behavior of the oxidation layer in artificial saliva was evaluated and compared with that of the as-fabricated LPBF alloy. The results indicate that, as increasing the applied voltage and the processing time, the oxidation layer becomes uniform and integrated. The optimum parameters are with an applied voltage of 450 V and processing time of 40 min. The oxidation layer primarily contains α-Al2O3 and consists of two layers, i.e., a thin, compact and uniform inner layer and a porous outer layer. The formation of stable α-Al2O3 phase in the coating and its almost non-porous dense structure reduce the channels for corrosion ions to penetrate into the substrate through coating, thereby improving the corrosion resistance of TiNi alloy