Charging Station Optimization Project Based on the Matrix Flexible Charging Reactor

In accordance with the Principle of "scientific planning, moderate advancement, rational layout, and classification implementation", the genetic algorithm based on real coding will be improved in this paper for the "Hard to Charge" problem of electric vehicles and urban bus replacement project. Aiming at minimum construction, operation and maintenance, network loss, queuing and other costs, a model is established and an innovative layout of electric bus charging facilities based on Matrix Flexible Charging Reactors is proposed to make full use of resources and improve the "Hard to Charge" situation. Taking Zhuhai as an example, by predicting the number of electric buses in Zhuhai in the planning year, the different locations and capacities of the bus charging stations with smaller average annual comprehensive cost in the regions are realized. And the comprehensive cost of the charging station with Matrix Flexible Charging Reactors as the construction subject is compared with the charging piles’. The analysis shows that this optimization proposal can better meet the future charging demand of urban electric buses, and proves that the charging station with Matrix Flexible Charging Reactors as the main subject of construction is more cost-effective. It provides new ideas for charging facilities planning in other cities, which is conducive to creating a healthier and more orderly environment for electric vehicle charging facilities industry

Comparison of the efficacy of oral contraceptives and levonorgestrel intrauterine system in intermenstrual bleeding caused by uterine niche

This study aimed to compare the effectiveness of oral contraceptives and a levonorgestrel intrauterine system in treating intermenstrual bleeding due to uterine niche. We retrospectively analyzed 72 patients with intermenstrual bleeding due to uterine niche from January 2017 to December 2021, of whom 41 were treated with oral contraceptives and 31 with a levonorgestrel intrauterine system. Post-treatment follow-ups at 1, 3, and 6 months were conducted to compare the efficiency and adverse effects between the two groups. In the oral contraceptive group, the effectiveness rate was higher than 80% at 1- and 3-months post-treatment and higher than 90% at 6 months. In the levonorgestrel intrauterine system group, the effectiveness rates were 58.06%, 54.84%, and 61.29% at 1, 3, and 6 months of treatment, respectively. Oral contraceptives were more effective than the levonorgestrel intrauterine system in treating intermenstrual bleeding caused by uterine niche (p < 0.05)

Remote near-field spectroscopy of vibrational strong coupling between organic molecules and phononic nanoresonators

Vibrational strong coupling (VSC) promises ultrasensitive IR spectroscopy and modification of material properties. Here, nanoscale mapping of VSC between organic molecules and individual IR nanoresonators is achieved by remote near-field spectroscopy. Phonon polariton (PhP) nanoresonators can dramatically enhance the coupling of molecular vibrations and infrared light, enabling ultrasensitive spectroscopies and strong coupling with minute amounts of matter. So far, this coupling and the resulting localized hybrid polariton modes have been studied only by far-field spectroscopy, preventing access to modal near-field patterns and dark modes, which could further our fundamental understanding of nanoscale vibrational strong coupling (VSC). Here we use infrared near-field spectroscopy to study the coupling between the localized modes of PhP nanoresonators made of h-BN and molecular vibrations. For a most direct probing of the resonator-molecule coupling, we avoid the direct near-field interaction between tip and molecules by probing the molecule-free part of partially molecule-covered nanoresonators, which we refer to as remote near-field probing. We obtain spatially and spectrally resolved maps of the hybrid polariton modes, as well as the corresponding coupling strengths, demonstrating VSC on a single PhP nanoresonator level. Our work paves the way for near-field spectroscopy of VSC phenomena not accessible by conventional techniques.This work was supported by the MCIN/AEI/10.13039/501100011033 under the María de Maeztu Units of Excellence Program (CEX2020-001038-M) and the Projects RTI2018-094830-B-100, PID2021-123949OB-I00, PID2019-107432GB-I00 and PID2021-122511OB-I00, as well as by the Graphene Flagship (GrapheneCore3, No. 881603). J.L. and J.H.E. are grateful for support from the Office of Naval Research (Award No. N00014-20-1-2474), for the BN crystal growth. S.V. acknowledges financial support by the Comunidad de Madrid through the Atracción de Talento program (grant no. 2020-T1/IND-20041). C.M.-E., R.E., and J.A. received funding from grant no. IT 1526-22 from the Basque Government for consolidated groups of the Basque University

Overexpression of Polo-like kinase1 (PLK1) in chondrosarcoma and its implications for cancer progression

Polo-like kinase1 (PLK1) is a new therapeutic target for osteosarcoma with good application prospects. Whether PLK1 is highly expressed in chondrosarcoma and whether PLK1 can be a potential therapeutic target for chondrosarcoma are worth exploring. However, PLK1 expression in chondrosarcoma is scarcely investigated. Therefore, we collected 11 cases of chondrosarcoma and 26 cases of osteochondroma with complete clinical pathological data and used immunohistochemical staining to detect the expression of PLK1 in chondrosarcoma and osteochondroma and then studied its significance and relationship with clinical pathological parameters. Our results showed that the positive expression rate of PLK1 in chondrosarcoma tissue (90.91%, 10/11) was significantly higher than the rate of osteochondroma tissues (53.85%, 14/26) (

Incorporation of black phosphorus nanosheets into poly(propylene fumarate) biodegradable bone cement to enhance bioactivity and osteogenesis

Abstract Background Injectable bone cement is commonly used in clinical orthopaedics to fill bone defects, treat vertebral compression fractures, and fix joint prostheses during joint replacement surgery. Poly(propylene fumarate) (PPF) has been proposed as a biodegradable and injectable alternative to polymethylmethacrylate (PMMA) bone cement. Recently, there has been considerable interest in two-dimensional (2D) black phosphorus nanomaterials (BPNSs) in the biomedical field due to their excellent photothermal and osteogenic properties. In this study, we investigated the biological and physicochemical qualities of BPNSs mixed with PPF bone cement created through thermal cross-linking. Methods PPF was prepared through a two-step process, and BPNSs were prepared via a liquid phase stripping method. BP/PPF was subsequently prepared through thermal cross-linking, and its characteristics were thoroughly analysed. The mechanical properties, cytocompatibility, osteogenic performance, degradation performance, photothermal performance, and in vivo toxicity of BP/PPF were evaluated. Results BP/PPF exhibited low cytotoxicity levels and mechanical properties similar to that of bone, whereas the inclusion of BPNSs promoted preosteoblast adherence, proliferation, and differentiation on the surface of the bone cement. Furthermore, 200 BP/PPF demonstrated superior cytocompatibility and osteogenic effects, leading to the degradation of PPF bone cement and enabling it to possess photothermal properties. When exposed to an 808-nm laser, the temperature of the bone cement increased to 45–55 °C. Furthermore, haematoxylin and eosin-stained sections from the in vivo toxicity test did not display any anomalous tissue changes. Conclusion BP/PPF exhibited mechanical properties similar to that of bone: outstanding photothermal properties, cytocompatibility, and osteoinductivity. BP/PPF serves as an effective degradable bone cement and holds great potential in the field of bone regeneration

Design and Analysis of a Light-Operated Microgripper Using an Opto-Electrostatic Repulsive Combined Actuator

The microgripper plays a critical role in micromanipulation systems; however, the handling accuracy of traditional driving microgrippers suffers from external vibration due to requiring connecting wires for an external power supply. By contrast, light driving has many advantages of remote non-contact manipulation, wireless energy transfer and no induced electromagnetic noise. In this study, an opto-electrostatic repulsive combined driving mechanism was proposed, and then a novel light-operated microgripper that used an opto-electrostatic repulsive actuator was designed and simulated. The static performance of the light-operated microgripper was investigated via simulation and numeric calculation results. The overall size of the microgripper was 1.3 mm × 0.7 mm × 1.027 mm, and the micro-objects ranging from 0 to 1000 μm in size could be manipulated and held using light. The proposed microgripper had many outstanding characteristics, such as a larger stroke, high response speed, remote non-contact manipulation, easy to integrate with an integrated circuit (IC) process and free from external interference. In addition, the dynamic control experiments of the photo-induced voltage of the PbLaZrTi (PLZT) ceramic were carried out, which shows that a stable electrical field could be obtained using the effective control methods that were developed

Extraction of sEMG Signal in Upper Limb Rehabilitation Robot

The limb motor dysfunction caused by cerebral injury brings a heavy burden to the patients family and society. The scientific rehabilitation training helps a lot in the recovery of limb motor function. The treatment of nerve rehabilitation is a hard work. At present, it mainly relies on the hand operation of rehabilitation physician to take rehabilitation exercises. It limits the improvement of rehabilitation. The combination of rehabilitation medicine and robot technology improves the efficiency of rehabilitation training and ensures the strength of action training, which has created a new way for the research on new rehabilitation technology. With the interdisciplinary development and integration, the rehabilitation medicine and the rehabilitation robot has been further studied and explored. The sEMG signal is one of the most important data in the limb rehabilitation, especially in upper limb rehabilitation robot. In the development of rehabilitation robot, the extraction of sEMG signal in upper limb rehabilitation is investigated deeply. The paper focuses on the status of the extraction of sEMG signal. In the end, the development trend for the future is discussed