Assessing Behavioral Health Risks, Health Conditions, and Preventive Health Practices among American Indians/Alaska Natives in Nevada

The 2004 Behavioral Risk Factor Surveillance System (BRFSS) survey was administered to American Indian/Alaska Native (AI/AN) adults in Nevada to determine whether health disparities exist between AI/ANs and the state’s general population. Results showed AI/ANs were 1.5 times more likely to smoke cigarettes, 3.5 times more likely to be exposed to secondhand smoke, 3.2 times more likely to lack leisure-time physical activity, 9.7 times more likely to report fair/poor health status, and 7.7 times more likely to have a disability. In addition, AI/ANs were more likely to have current asthma (OR=5.0) and diabetes (OR=1.8). AI/AN women were 4.8 times as likely to report no Pap test in the past 3 years. Our findings suggest that Nevada’s AI/AN population face many health disparities related to risk behaviors, poor health status and health conditions, and healthcare access. Partnerships among tribal, state and federal public health systems are needed to address these disparities

Pre-miRNA Loop Nucleotides Control the Distinct Activities of mir-181a-1 and mir-181c in Early T Cell Development

Mature miRNAs can often be classified into large families, consisting of members with identical seeds (nucleotides 2 through 7 of the mature miRNAs) and highly homologous approximately 21-nucleotide (nt) mature miRNA sequences. However, it is unclear whether members of a miRNA gene family, which encode identical or nearly identical mature miRNAs, are functionally interchangeable in vivo.We show that mir-181a-1, but not mir-181c, can promote CD4 and CD8 double-positive (DP) T cell development when ectopically expressed in thymic progenitor cells. The distinct activities of mir-181a-1 and mir-181c are largely determined by their unique pre-miRNA loop nucleotides-not by the one-nucleotide difference in their mature miRNA sequences. Moreover, the activity of mir-181a-1 on DP cell development can be quantitatively influenced by nucleotide changes in its pre-miRNA loop region. We find that both the strength and the functional specificity of miRNA genes can be controlled by the pre-miRNA loop nucleotides. Intriguingly, we note that mutations in the pre-miRNA loop regions affect pre-miRNA and mature miRNA processing, but find no consistent correlation between the effects of pre-miRNA loop mutations on the levels of mature miRNAs and the activities of the mir-181a-1/c genes.These results demonstrate that pre-miRNA loop nucleotides play a critical role in controlling the activity of miRNA genes and that members of the same miRNA gene families could have evolved to achieve different activities via alterations in their pre-miRNA loop sequences, while maintaining identical or nearly identical mature miRNA sequences

Predicting Lyα Emission from Galaxies via Empirical Markers of Production and Escape in the KBSS

Lyα emission is widely used to detect and confirm high-redshift galaxies and characterize the evolution of the intergalactic medium (IGM). However, many galaxies do not display Lyα emission in typical spectroscopic observations, and intrinsic Lyα emitters represent a potentially biased set of high-redshift galaxies. In this work, we analyze a set of 703 galaxies at 2 ≾ z ≾ 3 with both Lyα spectroscopy and measurements of other rest-frame ultraviolet and optical properties in order to develop an empirical model for Lyα emission from galaxies and understand how the probability of Lyα emission depends on other observables. We consider several empirical proxies for the efficiency of Lyα photon production, as well as the subsequent escape of these photons through their local interstellar medium. We find that the equivalent width of metal-line absorption and the O3 ratio of rest-frame optical nebular lines are advantageous empirical proxies for Lyα escape and production, respectively. We develop a new quantity, X_(LIS)^(O3), that combines these two properties into a single predictor of net Lyα emission, which we find describes ~90% of the observed variance in Lyα equivalent width when accounting for our observational uncertainties. We also construct conditional probability distributions demonstrating that galaxy selection based on measurements of galaxy properties yield samples of galaxies with widely varying probabilities of net Lyα emission. The application of the empirical models and probability distributions described here may be used to infer the selection biases of current galaxy surveys and evaluate the significance of high-redshift Lyα (non)detections in studies of reionization and the IGM

Imaging Spectroscopy of Ionized Gaseous Nebulae around Optically Faint AGNs at Redshift z ∼ 2

We present Keck/OSIRIS laser guide-star assisted adaptive optics (LGSAO) integral-field spectroscopy of [O III] λ5007 nebular emission from 12 galaxies hosting optically faint (R = 20–25; ν L_ν ~ 10^(44) – 10^(46) erg s^(−1)) active galactic nuclei (AGNs) at redshift z ~ 2–3. In combination with deep Hubble Space Telescope Wide Field Camera 3 (HST/WFC3) rest-frame optical imaging, Keck/MOSFIRE rest-optical spectroscopy, and Keck/KCWI rest-UV integral-field spectroscopy, we demonstrate that both the continuum and emission-line structures of these sources exhibit a wide range of morphologies, from compact, isolated point sources to double-AGN merging systems with extensive ~50 kpc tidal tails. One of the 12 galaxies previously known to exhibit a proximate damped Lyα system coincident in redshift with the galaxy shows evidence for both an extended [O III] narrow-line emission region and spatially offset Lyα emission (with morphologically distinct blueshifted and redshifted components) indicative of large-scale gas flows photoionized by the central AGN. We do not find widespread evidence of star formation in the host galaxies surrounding these AGNs; the [O III] velocity dispersions tend to be high (σ = 100–500 km s^(-1)), the continuum morphologies are much more compact than a mass-matched star-forming comparison sample, and the diagnostic nebular emission-line ratios are dominated by an AGN-like ionizing spectrum. The sample is most consistent with a population of AGNs that radiate at approximately their Eddington limit and photoionize extended [O III] nebulae whose characteristic sizes scale approximately as the square root of the AGN luminosity

Calibrating Galaxy Redshifts Using Absorption by the Surrounding Intergalactic Medium

Rest-frame UV spectral lines of star-forming galaxies are systematically offset from the galaxies' systemic redshifts, probably because of large-scale outflows. We calibrate galaxy redshifts measured from rest-frame UV lines by utilizing the fact that the mean HI Ly-alpha absorption profiles around the galaxies, as seen in spectra of background objects, must be symmetric with respect to the true galaxy redshifts if the galaxies are oriented randomly with respect to the lines of sight to the background objects. We use 15 QSOs at z~2.5-3 and more than 600 foreground galaxies with spectroscopic redshifts at z~1.9-2.5. All galaxies are within 2 Mpc proper from the lines of sight to the background QSOs. We find that LyA emission and ISM absorption redshifts require systematic shifts of v_LyA=-295(+35)(-35) km/s and v_ISM=145(+70)(-35) km/s. Assuming a Gaussian distribution, we put 1-sigma upper limits on possible random redshift offsets of <220 km/s for LyA and <420 km/s for ISM redshifts. For the small subset (<10%) of galaxies for which near-IR spectra have been obtained, we can compare our results to direct measurements based on nebular emission lines which we confirm to mark the systemic redshifts. While our v_ISM agrees with the direct measurements, our v_LyA is significantly smaller. However, when we apply our method to the near-IR subsample which is characterized by slightly different selection effects, the best-fit velocity offset comes into agreement with the direct measurement. This confirms the validity of our approach, and implies that no single number appropriately describes the whole population of galaxies, in line with the observation that the line offset depends on galaxy spectral morphology. This method provides accurate redshift calibrations and will enable studies of circumgalactic matter around galaxies for which rest-frame optical observations are not available.Comment: 7 pages, 3 figures, accepted for publication in MNRA

Survey, Excavation, and Geophysics at Songjiaheba—A Small Bronze Age Site in the Chengdu Plain

Archaeological survey in the Chengdu Plain of Sichuan Province has revealed settlement patterns surrounding Late Neolithic walled sites, including large numbers of small settlements from the Neolithic, Bronze Age, and Han Dynasty eras. Here geophysical survey and excavation at one of these small-scale sites dating to the Middle Bronze Age are reported, showing for the first time the value of high-resolution geophysics for evaluating site size and integrity in the Chengdu region

The connection between the escape of ionizing radiation and galaxy properties at z~3 in the Keck Lyman Continuum Spectroscopic Survey

The connection between the escape fraction of ionizing radiation ($f_{esc}$) and the properties of galaxies, such as stellar mass (M*), age, star-formation rate (SFR), and dust content, are key inputs for reionization models, but many of these relationships remain untested at high redshift. We present an analysis of a sample of 96 z~3 galaxies from the Keck Lyman Continuum Spectroscopic Survey (KLCS). These galaxies have both sensitive Keck/LRIS spectroscopic measurements of the Lyman continuum (LyC) region, and multi-band photometry that places constraints on stellar population parameters. We construct composite spectra from subsamples binned as a function of galaxy property and quantify the ionizing-photon escape for each composite. We find a significant anti-correlation between $f_{esc}$ and M*, consistent with predictions from cosmological zoom-in simulations. We also find significant anti-correlation between $f_{esc}$ and E(B-V), encoding the underlying physics of LyC escape in our sample. We also find no significant correlation between $f_{esc}$ and either stellar age or specific SFR (=SFR/M*), challenging interpretations that synchronize recent star formation and favorable conditions for ionizing escape. The galaxy properties now shown to correlate with $f_{esc}$ in the KLCS are Ly$\alpha$ equivalent width, UV Luminosity, M*, SFR, and E(B-V), but not age or sSFR. To date, this is the most comprehensive analysis of galaxy properties and LyC escape at high redshift, and will be used to guide future models and observations of the reionization epoch.Comment: 13 pages, 5 figures, submitted to MNRA

The Cosmic Ultraviolet Baryon Survey (CUBS) I. Overview and the diverse environments of Lyman limit systems at z<1

We present initial results from the Cosmic Ultraviolet Baryon Survey (CUBS). CUBS is designed to map diffuse baryonic structures at redshift z<~1 using absorption-line spectroscopy of 15 UV-bright QSOs with matching deep galaxy survey data. CUBS QSOs are selected based on their NUV brightness to avoid biases against the presence of intervening Lyman Limit Systems (LLSs) at zabs~ 17.2 over a total redshift survey pathlength of dz=9.3, and a number density of n(z)=0.43 (-0.18, +0.26). Considering all absorbers with log N(HI)/cm^-2 > 16.5 leads to n(z)=1.08 (-0.25, +0.31) at z<1. All LLSs exhibit a multi-component structure and associated metal transitions from multiple ionization states such as CII, CIII, MgII, SiII, SiIII, and OVI absorption. Differential chemical enrichment levels as well as ionization states are directly observed across individual components in three LLSs. We present deep galaxy survey data obtained using the VLT-MUSE integral field spectrograph and the Magellan Telescopes, reaching sensitivities necessary for detecting galaxies fainter than 0.1L* at d<~300 physical kpc (pkpc) in all five fields. A diverse range of galaxy properties is seen around these LLSs, from a low-mass dwarf galaxy pair, a co-rotating gaseous halo/disk, a star-forming galaxy, a massive quiescent galaxy, to a galaxy group. The closest galaxies have projected distances ranging from d=15 to 72 pkpc and intrinsic luminosities from ~0.01L* to ~3L*. Our study shows that LLSs originate in a variety of galaxy environments and trace gaseous structures with a broad range of metallicities.Comment: 26 pages, 14 figures, MNRAS in pres