2,681 research outputs found
Does Renewable Energy Renew the Endeavor in Energy Efficiency?
Improvement in energy efficiency (EE) has slowed globally since 2015 and is now falling short of the 2.6% per year target recommended by the United Nations Sustainable Development Goals, despite an abundance of EE opportunities. Barriers to EE have existed long before the rise in renewable energy (RE) investment. However, increased RE adoption may have unintended consequences for improving EE as adoption may raise or lower the barriers to EE. In this paper, we examine whether and how RE adoption can increase or decrease EE improvement. On the one hand, RE represent a competitor to EE for managerial attention and budget. On the other, the adoption of RE may increase the overall awareness of energy usage and drive EE improvement. Using site-level data from an industrial conglomerate, we estimate the impact of changes in RE usage and in the acquisition approach on the EE of 183 manufacturing sites across the globe from 2015 to 2020. On average, we find that using RE to meet 10% more of a site’s energy demand led to an additional 2.0% improvement in EE. However, there is significant heterogeneity in the effects depending on the acquisition approach. We find that while purchasing RE credits or entering into power purchase agreements led to gains in EE, installing on-site RE generators had no effect. To understand these gains, we surveyed site managers regarding their attitudes and intentions. The results suggest that there was a greater focus on EE by both managers and workers after increasing their RE usage. We also find quantitative evidence of managers submitting more budget requests for EE improvements in the twelve months following increases in RE. For corporations looking to use more RE, we offer evidence of additional returns in the form of energy savings, but realizing them requires careful consideration of the acquisition approach of RE
Local clonal diversification and dissemination of B lymphocytes in the human bronchial mucosa
Feedback Effect in User Interaction with Intelligent Assistants: Delayed Engagement, Adaption and Drop-out
With the growing popularity of intelligent assistants (IAs), evaluating IA
quality becomes an increasingly active field of research. This paper identifies
and quantifies the feedback effect, a novel component in IA-user interactions:
how the capabilities and limitations of the IA influence user behavior over
time. First, we demonstrate that unhelpful responses from the IA cause users to
delay or reduce subsequent interactions in the short term via an observational
study. Next, we expand the time horizon to examine behavior changes and show
that as users discover the limitations of the IA's understanding and functional
capabilities, they learn to adjust the scope and wording of their requests to
increase the likelihood of receiving a helpful response from the IA. Our
findings highlight the impact of the feedback effect at both the micro and meso
levels. We further discuss its macro-level consequences: unsatisfactory
interactions continuously reduce the likelihood and diversity of future user
engagements in a feedback loop.Comment: PAKDD 202
The Influence of Molecular Adsorption on Elongating Gold Nanowires
Using molecular dynamics simulations, we study the impact of physisorbing
adsorbates on the structural and mechanical evolution of gold nanowires (AuNWs)
undergoing elongation. We used various adsorbate models in our simulations,
with each model giving rise to a different surface coverage and mobility of the
adsorbed phase. We find that the local structure and mobility of the adsorbed
phase remains relatively uniform across all segments of an elongating AuNW,
except for the thinning region of the wire where the high mobility of Au atoms
disrupts the monolayer structure, giving rise to higher solvent mobility. We
analyzed the AuNW trajectories by measuring the ductile elongation of the wires
and detecting the presence of characteristic structural motifs that appeared
during elongation. Our findings indicate that adsorbates facilitate the
formation of high-energy structural motifs and lead to significantly higher
ductile elongations. In particular, our simulations result in a large number of
monatomic chains and helical structures possessing mechanical stability in
excess of what we observe in vacuum. Conversely, we find that a molecular
species that interacts weakly (i.e., does not adsorb) with AuNWs worsens the
mechanical stability of monatomic chains.Comment: To appear in Journal of Physical Chemistry
Large-Scale Atomistic Simulations of Environmental Effects on the Formation and Properties of Molecular Junctions
Using an updated simulation tool, we examine molecular junctions comprised of
benzene-1,4-dithiolate bonded between gold nanotips, focusing on the importance
of environmental factors and inter-electrode distance on the formation and
structure of bridged molecules. We investigate the complex relationship between
monolayer density and tip separation, finding that the formation of
multi-molecule junctions is favored at low monolayer density, while
single-molecule junctions are favored at high density. We demonstrate that tip
geometry and monolayer interactions, two factors that are often neglected in
simulation, affect the bonding geometry and tilt angle of bridged molecules. We
further show that the structures of bridged molecules at 298 and 77 K are
similar.Comment: To appear in ACS Nano, 30 pages, 5 figure
Composition of the Pseudoscalar Eta and Eta' Mesons
The composition of the eta and eta' mesons has long been a source of
discussion and is of current interest with new experimental results appearing.
We investigate what can be learnt from a number of different processes: V to P
gamma and P to V gamma (V and P are light vector and pseudoscalar mesons
respectively), P to gamma gamma, J/psi,psi' to P gamma, J/psi,psi' to P V, and
chi_{c0,2} to PP. These constrain the eta-eta' mixing angle to a consistent
value, phi approx 42 degrees; we find that the c cbar components are lesssim 5%
in amplitude. We also find that, while the data hint at a small gluonic
component in the eta', the conclusions depend sensitively on unknown form
factors associated with exclusive dynamics. In addition, we predict BR(psi' to
eta' gamma) approx 1 10^{-5} and BR(chi_{c0} to eta eta') approx 2 10^{-5} - 1
10^{-4}. We provide a method to test the mixing using chi_{c2} to eta eta, eta'
eta', and eta eta' modes and make some general observations on chi_{c0,2}
decays. We also survey the semileptonic and hadronic decays of bottom and
charmed mesons and find some modes where the mixing angle can be extracted
cleanly with the current experimental data, some where more data will allow
this, and some where a more detailed knowledge of the different amplitudes is
required.Comment: 34 pages, 11 figures. v2: version published in JHEP, added
substantial section on B and D meson electroweak decays, added comment on
psi' to eta(')/eta_c gamma, Figs 5 and 6 split and made clearer, added
references, other minor revisions which don't change conclusion
Small-Scale Structure in the SDSS and LCDM: Isolated L* Galaxies with Bright Satellites
We use a volume-limited spectroscopic sample of isolated galaxies in the
Sloan Digital Sky Survey (SDSS) to investigate the frequency and radial
distribution of luminous (M_r <~ -18.3) satellites like the Large Magellanic
Cloud (LMC) around ~L* Milky Way analogs and compare our results
object-by-object to LCDM predictions based on abundance matching in
simulations. We show that 12% of Milky Way-like galaxies host an LMC-like
satellite within 75 kpc (projected), and 42 % within 250 kpc (projected). This
implies ~10% have a satellite within the distance of the LMC, and ~40% of L*
galaxies host a bright satellite within the virialized extent of their dark
matter halos. Remarkably, the simulation reproduces the observed frequency,
radial dependence, velocity distribution, and luminosity function of observed
secondaries exceptionally well, suggesting that LCDM provides an accurate
reproduction of the observed Universe to galaxies as faint as L~10^9 Lsun on
~50 kpc scales. When stacked, the observed projected pairwise velocity
dispersion of these satellites is sigma~160 km/s, in agreement with
abundance-matching expectations for their host halo masses. Finally, bright
satellites around L* primaries are significantly redder than typical galaxies
in their luminosity range, indicating that environmental quenching is operating
within galaxy-size dark matter halos that typically contain only a single
bright satellite. This redness trend is in stark contrast to the Milky Way's
LMC, which is unusually blue even for a field galaxy. We suggest that the LMC's
discrepant color might be further evidence that it is undergoing a triggered
star-formation event upon first infall.Comment: 14 pages, 11 figures; accepted to Ap
Zero-Temperature Phase Transitions of Antiferromagnetic Ising Model of General Spin on a Triangular Lattice
We map the ground-state ensemble of antiferromagnetic Ising model of spin-S
on a triangular lattice to an interface model whose entropic fluctuations are
proposed to be described by an effective Gaussian free energy, which enables us
to calculate the critical exponents of various operators in terms of the
stiffness constant of the interface. Monte Carlo simulations for the
ground-state ensemble utilizing this interfacial representation are performed
to study both the dynamical and the static properties of the model. This method
yields more accurate numerical results for the critical exponents. By varying
the spin magnitude in the model, we find that the model exhibits three phases
with a Kosterlitz-Thouless phase transition at 3/2<S_{KT}<2 and a locking phase
transition at 5/2 < S_L \leq 3. The phase diagram at finite temperatures is
also discussed.Comment: 15 pages, LaTeX; 10 figures in PostScript files; The revised version
appears in PRB (see Journal-ref). New electronic address of first author,
[email protected]
Trafficking Defect and Proteasomal Degradation Contribute to the Phenotype of a Novel KCNH2 Long QT Syndrome Mutation
The Kv11.1 (hERG) K+ channel plays a fundamental role in cardiac repolarization. Missense mutations in KCNH2, the gene encoding Kv11.1, cause long QT syndrome (LQTS) and frequently cause channel trafficking-deficiencies. This study characterized the properties of a novel KCNH2 mutation discovered in a LQT2 patient resuscitated from a ventricular fibrillation arrest. Proband genotyping was performed by SSCP and DNA sequencing. The electrophysiological and biochemical properties of the mutant channel were investigated after expression in HEK293 cells. The proband manifested a QTc of 554 ms prior to electrolyte normalization. Mutation analysis revealed an autosomal dominant frameshift mutation at proline 1086 (P1086fs+32X; 3256InsG). Co-immunoprecipitation demonstrated that wild-type Kv11.1 and mutant channels coassemble. Western blot showed that the mutation did not produce mature complex-glycosylated Kv11.1 channels and coexpression resulted in reduced channel maturation. Electrophysiological recordings revealed mutant channel peak currents to be similar to untransfected cells. Co-expression of channels in a 1∶1 ratio demonstrated dominant negative suppression of peak Kv11.1 currents. Immunocytochemistry confirmed that mutant channels were not present at the plasma membrane. Mutant channel trafficking rescue was attempted by incubation at reduced temperature or with the pharmacological agents E-4031. These treatments did not significantly increase peak mutant currents or induce the formation of mature complex-glycosylated channels. The proteasomal inhibitor lactacystin increased the protein levels of the mutant channels demonstrating proteasomal degradation, but failed to induce mutant Kv11.1 protein trafficking. Our study demonstrates a novel dominant-negative Kv11.1 mutation, which results in degraded non-functional channels leading to a LQT2 phenotype
- …