15 research outputs found
First-order indicators for the estimation of discrete fractures in porous media
International audienceFaults and geological barriers can drastically affect the flow patterns in porous media. Such fractures can be modeled as interfaces that interact with the surrounding matrix. We propose a new technique for the estimation of the location and hydrogeological properties of a small number of large fractures in a porous medium from given distributed pressure or flow data. At each iteration, the algorithm builds a short list of candidates by comparing fracture indicators. These indicators quantify at the first order the decrease of a data misfit function; they are cheap to compute. Then, the best candidate is picked up by minimization of the objective function for each candidate. Optimally driven by the fit to the data, the approach has the great advantage of not requiring remeshing, nor shape derivation. The stability of the algorithm is shown on a series of numerical examples representative of typical situations.Les écoulements dans les milieux poreux peuvent être radicalement modifiés par la présence de failles ou de barrières géologiques.De telles fractures peuvent être modélisées comme des interfaces qui interagissent avec la matrice environnante. Nous proposons une nouvelle technique pour l'estimation de l'emplacement et des propriétés hydrogéologiques d'un petit nombre de grandes fractures dans un milieu poreux à partir de mesures distribuées de pression ou de flux données. À chaque itération, l'algorithme construit une courte liste de candidats par comparaison d'indicateurs de fracture. Ces indicateurs quantifient au premier ordre la décroissance d'une fonctiond'écart aux données; ils sont peut coûteux à calculer. Le meilleur candidat est ensuite isolé par minimisation de la fonctionobjectif pour chaque candidat. Guidée de façon optimale par la reproduction des données, l'approche a le grand avantage de ne pas nécessiter de remaillage, ni de dérivation de forme. La stabilité de l'algorithme est montrée sur une série d'exemples numériquesreprésentatifs de situations typiques
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance.
Investment in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing in Africa over the past year has led to a major increase in the number of sequences that have been generated and used to track the pandemic on the continent, a number that now exceeds 100,000 genomes. Our results show an increase in the number of African countries that are able to sequence domestically and highlight that local sequencing enables faster turnaround times and more-regular routine surveillance. Despite limitations of low testing proportions, findings from this genomic surveillance study underscore the heterogeneous nature of the pandemic and illuminate the distinct dispersal dynamics of variants of concern-particularly Alpha, Beta, Delta, and Omicron-on the continent. Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve while the continent faces many emerging and reemerging infectious disease threats. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance
INTRODUCTION
Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic.
RATIONALE
We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs).
RESULTS
Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants.
CONCLUSION
Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century
Identification of fractures in porous medium
Cette thèse est consacrée à l'étude mathématique d'un problème inverse en hydrogéologie : le but est d'identifier des fractures en milieu poreux, connaissant des mesures de l'écoulement dans le sous-sol. Le nombre, la localisation et les paramètres physiques des fractures sont recherchés. Ce problème est formulé comme la minimisation au sens des moindres carrés d'une fonctionnelle évaluant l'écart entre les mesures et les résultats du modèle direct. L'écoulement est celui d'un fluide monophasique incompressible (loi de Darcy). Un modèle traitant les fractures comme des interfaces est utilisé. Le problème direct est le modèle de fracture discrétisé par la méthode des éléments finis mixtes hybrides.Pour résoudre ce problème inverse, un nouvel algorithme itératif a été développé, basé sur l’utilisation d’indicateurs de fractures mis au point pendant la thèse. Ces indicateurs donnent une information au premier ordre concernant l'effet de l'ajout d'une nouvelle fracture. Comme ces indicateurs sont peu coûteux, un grand nombre de configurations de fractures sont testées à chaque itération. L’algorithme a été programmé, validé puis testé numériquement dans des situations variées, en utilisant des mesures synthétiques. Il donne des résultats très satisfaisants, bien que ce problème soit réputé difficile.Enfin, l’étude de l’identifiabilité du problème inverse a été amorcée. Pour un modèle simplifié de fractures (failles très perméables, cas le plus courant dans le sous-sol), on a montré que le problème.This PhD is dedicated to the mathematical study of an inverse problem in hydrogeology: the goal is to identify fractures in porous medium, knowing measurements of the underground flow. The number, the location and the physical parameters of the fracture are looked for. This problem is formulated as the least squares minimization of a function evaluating the misfit between measurements and the result of the direct model. We used a model describing the flow of a monophasic incompressible fluid (Darcy's law), in a porous medium containing some fractures represented by interfaces. The direct problem is the fracture model discretized by the mixed hybrid finite element method. To solve this inverse problem, we developed an iterative algorithm, which is based on the use of fracture indicators that have been developed durig the thesis. These indicators give a first order information concerning the effect of the addition of a new fracture. As these indicators are inexpensive, a large number of configurations of new fractures is tested at each iteration. The algorithm was programmed, validated and tested numerically in various situations, using synthetic measurements. It gives very satisfactory results, although this problem is considered difficult. Finally, an early study of identifiability of the inverse problem of fractures in porous medium has been achieved. It allowed to prove the identifiability for a simplified model (very permeable faults, which is common in the underground). The question of identifiability for the full fracture model remains open
Identification de fractures dans un milieu poreux
This PhD is dedicated to the mathematical study of an inverse problem in hydrogeology: the goal is to identify fractures in porous medium, knowing measurements of the underground flow. The number, the location and the physical parameters of the fracture are looked for. This problem is formulated as the least squares minimization of a function evaluating the misfit between measurements and the result of the direct model. We used a model describing the flow of a monophasic incompressible fluid (Darcy's law), in a porous medium containing some fractures represented by interfaces. The direct problem is the fracture model discretized by the mixed hybrid finite element method. To solve this inverse problem, we developed an iterative algorithm, which is based on the use of fracture indicators that have been developed durig the thesis. These indicators give a first order information concerning the effect of the addition of a new fracture. As these indicators are inexpensive, a large number of configurations of new fractures is tested at each iteration. The algorithm was programmed, validated and tested numerically in various situations, using synthetic measurements. It gives very satisfactory results, although this problem is considered difficult. Finally, an early study of identifiability of the inverse problem of fractures in porous medium has been achieved. It allowed to prove the identifiability for a simplified model (very permeable faults, which is common in the underground). The question of identifiability for the full fracture model remains open.Cette thèse est consacrée à l'étude mathématique d'un problème inverse en hydrogéologie : le but est d'identifier des fractures en milieu poreux, connaissant des mesures de l'écoulement dans le sous-sol. Le nombre, la localisation et les paramètres physiques des fractures sont recherchés. Ce problème est formulé comme la minimisation au sens des moindres carrés d'une fonctionnelle évaluant l'écart entre les mesures et les résultats du modèle direct. L'écoulement est celui d'un fluide monophasique incompressible (loi de Darcy). Un modèle traitant les fractures comme des interfaces est utilisé. Le problème direct est le modèle de fracture discrétisé par la méthode des éléments finis mixtes hybrides.Pour résoudre ce problème inverse, un nouvel algorithme itératif a été développé, basé sur l’utilisation d’indicateurs de fractures mis au point pendant la thèse. Ces indicateurs donnent une information au premier ordre concernant l'effet de l'ajout d'une nouvelle fracture. Comme ces indicateurs sont peu coûteux, un grand nombre de configurations de fractures sont testées à chaque itération. L’algorithme a été programmé, validé puis testé numériquement dans des situations variées, en utilisant des mesures synthétiques. Il donne des résultats très satisfaisants, bien que ce problème soit réputé difficile.Enfin, l’étude de l’identifiabilité du problème inverse a été amorcée. Pour un modèle simplifié de fractures (failles très perméables, cas le plus courant dans le sous-sol), on a montré que le problème
IMPLEMENT IT OR NOT? EXPLORING SOCIAL ACCEPTANCE OF RENEWABLE ENERGY PROJECTS IN TUNISIA
Social acceptance is considered as a very important phenomenon in the development of renewable energy projects and the accomplishment of the energy policy goals. The aim of this research is to explore the determinants of community acceptance of renewable energy technologies while focusing on consumer orientation towards these projects. A qualitative study based on a semantic analysis and a deductive approach is used to study the determinants of the phenomenon in question. This research paper concludes with the importance for more systematic studies about the phenomenon of community acceptance based on pertinent theoretical background depicted from psychology, social sciences, precise definitions, and a focusing emphasis on symbolic and emotional aspects
Chitin nanocrystals as Pickering stabilizer for O/W emulsions: Effect of the oil chemical structure on the emulsion properties
International audienceChitin nanocrystals (ChNCs) produced by hydrochloric acid hydrolysis of chitin were used as stabilizing agent for oil-in-water (O/W) emulsification of soybean oil (SO), acrylated soybean oil (ASO), and epoxidized soybean oil (ESO). The emulsion stability, droplet size, and rheology of the emulsion were found to be significantly affected by the oil chemical structure. Strong interaction between ChNCs and the oil droplets enhanced the stabilizing efficiency of ChNCs through a Pickering effect, resulting in emulsions with low droplet size and long-term stability. The use of ChNCs as stabilizer for O/W emulsions in replacement of synthetic surfactants opens new avenues to produce emulsions for a wide variety of applications, including cosmetic products, coating, inks and adhesives
Honeycomb Organization of Chitin Nanocrystals (ChNCs) in Nanocomposite Films of UV-Cured Waterborne Acrylated Epoxidized Soybean Oil Emulsified with ChNCs
International audienceStable biobased waterborne Pickering dispersions of acrylated epoxidized soybean oil (AESO) were developed using chitin nanocrystals (ChNCs) as sole emulsifier without any additives. Thin AESO-ChNC nanocomposite films were produced by UV-curing thin-coated layers of the AESO emulsion after water evaporation. The kinetics of photopolymerization was assessed by monitoring the consumption of the AESO acrylate groups by infrared spectroscopy (FTIR). The curing was faster in the presence of ChNCs, with a disappearance of the induction period observed for neat AESO. The coating of AESO droplets with a thin layer of ChNCs was confirmed by scanning electron microscopy (SEM) observation. SEM and transmission electron microscopy (TEM) images revealed the honeycomb organization of the ChNCs inside the cured AESO-ChNC films. The mechanical, thermal and optical properties of the nanocomposite films were studied by dynamic mechanical analysis (DMA), tensile testing, differential scanning calorimetry (DSC) and transmittance measurement, as a function of ChNC content. The inclusion of ChNCs is strongly beneficial to increase the stiffness and strength of the cured films, without compromising its optical transparency. The ability of ChNCs to act as an emulsifier for AESO in replacement of synthetic surfactants and their strong reinforcing effect in UV-cured films offer new opportunities to produce waterborne stable dispersions from AESO for application in biobased coatings and adhesives